Sideroblastic Anemia in 7 Dogs (1996-2002)

Abstract

Sideroblastic anemia is an anemic condition characterized by chronic hypochromic anemia and the presence of large iron deposits in erythroid cells. Seven dogs with sideroblastic anemia were evaluated retrospectively. Historical, clinical, and clinicopathologic findings were reviewed to determine whether the condition was idiopathic or associated with disease conditions or drug or toxin exposure. Associated diseases were identified in 6 affected dogs and included acute hepatitis, pancreatitis, acute hepatitis and pancreatitis, inflammatory disease, glomerulonephritis, and myelofibrosis. None of the dogs had a history of recent exposure to drugs or toxins. One dog had no evidence of associated disease. Regardless of the associated disease condition, sideroblastic anemia was characterized by moderate to severe nonregenerative and frequently hypochromic anemia with prominent dysplastic features in bone marrow that were most prominent in the erythroid series. Survival varied from days to years. Identification of large numbers of siderocytes or sideroblasts in blood or bone marrow is inconsistent with a diagnosis of iron deficiency and should prompt a search for inflammatory disease conditions, including hepatitis, pancreatitis, and glomerulonephritis.

A Retrospective Study of the Incidence and the Classification of Bone Marrow Disorders in the Dog at a Veterinary Teaching Hospital (1996–2004)

“…Dysmyelopoiesis was defined as a hematologic disorder characterized by the presence of morphologic abnormalities (ie, dysplasia) in 1 or more hematologic cell lines in the blood or bone marrow. [21][22][23][24][25][26][27][28] In this and a previous study, dysmyelopoiesis was divided into myelodysplastic syndromes, secondary dysmyelopoiesis, and congenital dysmyelopoiesis. 21 Myelodysplastic syndromes were subclassified as MDS with refractory cytopenias (MDS-RC), MDS with sideroblastic differentiation (MDS-SD), and MDS with excess (ie, 6-30%) myeloblasts (MDS-EB; some of these cases have been previously reported 27,28 ).…”

Peripheral blood cells of native pig (Zovawk) of Mizoram, India: Light and scanning electron microscopy analysis

“…The reason of this observation may be because of the lack of non-heme iron in the blood. On the other hand, siderocytes with their small blue color granular structures were noticed by Singh (2000) in buffalo calves, Weiss (2005Weiss ( , 2006 in dogs, Mrigesh (2011) in donkeys, andYadav et al (2015) in poultry.…”

Diagnostic Importance of Cytochemical and Cytoenzymatic Patterns of Peripheral Blood Cells in Native Cattle (Zobawng) of Mizoram, India

“…Similar findings were also reported by Mehta et al (2012) in the blood samples of pigs. However, Singh (2000) in buffalo calves, Weiss (2005;2006) in dog, Mrigesh (2011) in donkey and Yadav et al (2015) in fowl recorded some siderocytes with their small blue colour granular structure inside the erythrocytes.…”

“…Earlier some cytochemical studies of blood leucocytes have been investigated by Menaka and Singh (2002) in goat, Weiss (2005;2006) in dog, Mrigesh (2011) in donkey and Mehta et al (2012) in pig. To comprehend the body's reaction to any form of stress, proper cell identification and localization of the numerous cytoenzymes in them are critical.…”