Side Effects of Curcumin: Epigenetic and Antiproliferative Implications for Normal Dermal Fibroblast and Breast Cancer Cells

Cianfruglia, Laura; Minnelli, Cristina; Laudadio, Emiliano; Scirè, Andrea; Armeni, Tatiana

doi:10.3390/antiox8090382

Cited by 63 publications

(42 citation statements)

References 51 publications

(60 reference statements)

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“…Some authors have suggested that the increase in GSH levels in flavonoid treated cells could be related to transactivation of catalytical subunit promoter of the gamma-glutamyl-cysteine synthetase [ 60 ]. GSH is involved in cellular redox regulation as it can be used as a cofactor by enzymes involved in signal transduction [ 61 , 62 ], therefore our results suggest that polyphenol-mediated regulation of GSH levels could modulate cellular response in intestinal cells. Moreover, some flavonoids behave as natural inhibitors of GlxI [ 63 ].…”

Section: Discussionmentioning

confidence: 94%

Protection of Polyphenols against Glyco-Oxidative Stress: Involvement of Glyoxalase Pathway

et al. 2020

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Chronic high glucose (HG) exposure increases methylglyoxal (MGO)-derived advanced glycation end-products (AGEs) and is involved in the onset of pathological conditions, such as diabetes, atherosclerosis and chronic-degenerative diseases. Under physiologic conditions the harmful effects of MGO are contrasted by glyoxalase system that is implicated in the detoxification of Reactive Carbonyl Species (RCS) and maintain the homeostasis of the redox environment of the cell. Polyphenols are the most abundant antioxidants in the diet and present various health benefits. Aims of the study were to investigate the effects of HG-chronic exposure on glyco-oxidation and glyoxalase system in intestinal cells, using CaCo-2 cells. Moreover, we studied the effect of apple polyphenols on glyco-oxidative stress. Our data demonstrated that HG-treatment triggers glyco-oxidation stress with a significant increase in intracellular Reactive Oxygen Species (ROS), lipid peroxidation, AGEs, and increase of Glyoxalase I (GlxI) activity. On the contrary, Glyoxalase II (GlxII) activity was lower in HG-treated cells. We demonstrate that apple polyphenols exert a protective effect against oxidative stress and dicarbonyl stress. The increase of total antioxidant capacity and glutathione (GSH) levels in HG-treated cells in the presence of apple polyphenols was associated with a decrease of GlxI activity.

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Section: Discussionmentioning

confidence: 94%

Protection of Polyphenols against Glyco-Oxidative Stress: Involvement of Glyoxalase Pathway

et al. 2020

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“…Furthermore, in the same cell model, we studied the effect of apple polyphenols. The interest of the study is supported by literature data which demonstrate the ability of some polyphenols to modulate glyoxalase activity, oxidative and dicarbornyl stress as shown in different experimental models [22][23][24][25].…”

Section: Introductionmentioning

confidence: 86%

Protection of Polyphenols Against Glyco-Oxidative Stress: Involvement of Glyoxalase Pathway

Cianfruglia¹,

Morresi²,

Bacchetti³

et al. 2020

Preprint

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Chronic high glucose (HG) exposure increases methylglyoxal (MG)-derived AGEs and is involved in the onset of pathological conditions, such as diabetes, atherosclerosis and chronic‐degenerative diseases. Under physiologic condition the harmful effects of MG are contrasted by glyoxalase system that is involved in the detoxification of Reactive Carbonyl Species (RCS) and maintain the homeostasis of the redox environment of the cell. Polyphenols are the most abundant antioxidants in the diet and present various health benefits. The study aimed at investigating the role of polyphenols extracted from an apple high in polyphenols (Calville White Winter), on glyco-oxidative stress induced by chronic HG-exposure. Intestinal Caco-2 cells were treated in physiological glucose condition (25mM) as a control and in HG condition (50mM) with or without apple extract for one week. Our data demonstrated that HG-treatment triggers glyco-oxidation stress with a significantly increase in ROS, lipid peroxidation, AGEs and Glyoxalase I (GlxI) activity with a significant decrease in total antioxidant intracellular defense. Treatment with polyphenols under HG condition restores to the control levels GlxI activity, decreases Glyoxalase II (GlxII) in relation to the control and induces a drop of glyco-oxidative damage. This paper seeks to highlight the roles of polyphenols in glyco-oxidative stress.

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“…However, at high doses, it may produce toxic and carcinogenic effects in healthy cells. The cytotoxic effects observed after curcumin treatment may be due to post-translational modifications of histones, which lead to modifications in gene expression [13]. Additionally, a diet rich in fat can be associated with hypermethylation of specific DNA promoters of tumor suppressor genes [14].…”

Section: Epigenetic and Genetic Mechanisms For The Regulation Of Genementioning

confidence: 99%

Factors Influencing Epigenetic Mechanisms: Is There A Role for Bariatric Surgery?

Metere

Graves

2020

High-Throughput

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Epigenetics is the interaction between the genome and environmental stimuli capable of influencing gene expression during development and aging. A large number of studies have shown that metabolic diseases are highly associated with epigenetic alterations, suggesting that epigenetic factors may play a central role in obesity. To investigate these relationships, we focus our attention on the most common epigenetic modifications that occur in obesity, including DNA methylation and post-translational modifications of histones. We also consider bariatric surgery as an epigenetic factor, evaluating how the anatomic and physiologic modifications induced by these surgical techniques can change gene expression. Here we discuss the importance of epigenetic mechanisms in chronic disease and cancer, and the role of epigenetic disturbances in obesity, with a focus on the role of bariatric surgery.

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Side Effects of Curcumin: Epigenetic and Antiproliferative Implications for Normal Dermal Fibroblast and Breast Cancer Cells

Cited by 63 publications

References 51 publications

Protection of Polyphenols against Glyco-Oxidative Stress: Involvement of Glyoxalase Pathway

Protection of Polyphenols against Glyco-Oxidative Stress: Involvement of Glyoxalase Pathway

Protection of Polyphenols Against Glyco-Oxidative Stress: Involvement of Glyoxalase Pathway

Factors Influencing Epigenetic Mechanisms: Is There A Role for Bariatric Surgery?

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