2020 DOI: 10.20944/preprints202009.0383.v1 View full text Preprint
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Laura Cianfruglia, Camilla Morresi, Tiziana Bacchetti, Tatiana Armeni, Gianna Ferretti

Abstract: Chronic high glucose (HG) exposure increases methylglyoxal (MG)-derived AGEs and is involved in the onset of pathological conditions, such as diabetes, atherosclerosis and chronic‐degenerative diseases. Under physiologic condition the harmful effects of MG are contrasted by glyoxalase system that is involved in the detoxification of Reactive Carbonyl Species (RCS) and maintain the homeostasis of the redox environment of the cell. Polyphenols are the most abundant antioxidants in the diet and present various he…

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