Siamenflavones A-C, three undescribed biflavonoids from Selaginella siamensis Hieron. and biflavonoids from spike mosses as EGFR inhibitor

Demehin, Adebisi Adunola; Thamnarak, Wanlaya; Lamtha, Thomanai; Chatwichien, Jaruwan; Eurtivong, Chatchakorn; Choowongkomon, Kiattawee; Chainok, Kittipong; Ruchirawat, Somsak; Thasana, Nopporn

doi:10.1016/j.phytochem.2022.113374

Cited by 7 publications

(4 citation statements)

References 70 publications

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“…Low RMSD and RMSF values are often indicators of structural stability, and vice versa . 36 The RMSD values of this complex system all fluctuated below 2.5 Å after 20 ns, which indicatedg a relatively stable system (Fig. 6A).…”

Section: Resultsmentioning

confidence: 91%

Sesquiterpenoids isolated from the rhizome of Curcuma phaeocaulis Valeton: antitumor activity, in silico molecular docking and molecular dynamics study

et al. 2023

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Section: Resultsmentioning

confidence: 91%

Sesquiterpenoids isolated from the rhizome of Curcuma phaeocaulis Valeton: antitumor activity, in silico molecular docking and molecular dynamics study

et al. 2023

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“…Aurones were only detected in two species of Funariaceae (Geiger et al 1997;Weitz & Ikan 1977). Coumarins occur in most basal families, such as Davies et al 2020;Demehin et al 2022;Kulshrestha et al 2022;Wang et al 2005;Yonekura-Sakakibara et al 2019). Online pdf in color.…”

Section: Resultsmentioning

confidence: 99%

“…Each color represents the pathway present in each bryophyte group. PAL, phenylalanine ammonia-lyase; C4H, cinnamate 4-hydroxylase; 4CL, 4-coumarate:CoA ligase; CHS, chalcone synthase; CHI, chalcone isomerase; CHIL, chalcone isomerase-like; F3H, flavanone 3-hydroxylase; DFR, dihydroflavonol 4-reductase; FNR, flavanone reductase; IFS, isoflavone synthase; HID, 2-hydroxyisoflavanone dehydratase; ANS, anthocyanidin synthase; PPO, polyphenol oxidase (AUS/AS, aureusidin/aurone synthase); FNS, flavone synthase; FLS, flavonol synthase (Adapted from Davies et al 2020; Demehin et al 2022; Kulshrestha et al 2022; Wang et al 2005; Yonekura-Sakakibara et al 2019). Online pdf in color.…”

Section: Resultsmentioning

confidence: 99%

A chemistry overview of the beautiful miniature forest known as mosses

2023

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The bryophytes are the second largest group of land plants and are represented by three lineages: Marchantyophyta (liverworts), Anthocerotophyta (hornworts), and Bryophyta (mosses). They occupy a wide variety of habitats, from deserts to Antarctica, and exercise great ecological importance. These facts and their wide use in traditional medicine raise the question of what is known about moss chemistry. This paper gathered studies from the last 52 years about the compounds identified in mosses, aiming to address the following questions: Are mosses chemically under-studied? How many families, genera, and species of mosses have been chemically studied? Which continent and countries have been responsible for the majority of these studies? A literature search was performed in major scientific databases, using a combination of keywords. A total of 199 papers were compiled, of which 45% were published during the last decade. Only a small percentage of moss species has been studied, mostly from Europe and Asia. Dicranales and Hypnales are the most studied orders. In general, fatty acids and flavonoids are the most commonly reported classes of compounds. Biflavonoids and triflavonoids are detected mainly in derived clades of mosses, while coumarins are most reported for basal groups. Akthough only a small percentage of moss species has been chemically studied, most of these studies were published in the last decade—there has been a 135% increase in the number of reported compounds in the last 13 years. The emergence of new equipment, which can produce high-resolution spectra with small amounts of sample, combined with bioinformatics tools, has undoubtedly contributed to the increase of chemical investigation of mosses. Also, advances in the identification and phylogenetics of moss groups are contributing to a better understanding of them generally, which should lead also to increased study of moss chemistry.

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“…From Selaginella siamensis and Selaginella bryopteris, three novel biflavonoids known as siamamenflavones A-C (17)(18)(19) were isolated. One of them, siamamenflavone B (18), exhibited potent inhibition of wild-type EGFR protein [45]. Selaginella tamariscina yielded three novel biflavonoids: involvenflavone G (20), H (21), and I ( 22); H and I may have potent hypoglycemic effects [46].…”

Section: Structural Characteristics Of Selaginella Biflavonoidmentioning

confidence: 99%

Advances in the Anti-Tumor Activity of Biflavonoids in Selaginella

Ren

Gao

et al. 2023

IJMS

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Despite the many strategies employed to slow the spread of cancer, the development of new anti-tumor drugs and the minimization of side effects have been major research hotspots in the anti-tumor field. Natural drugs are a huge treasure trove of drug development, and they have been widely used in the clinic as anti-tumor drugs. Selaginella species in the family Selaginellaceae are widely distributed worldwide, and they have been well-documented in clinical practice for the prevention and treatment of cancer. Biflavonoids are the main active ingredients in Selaginella, and they have good biological and anti-tumor activities, which warrant extensive research. The promise of biflavonoids from Selaginella (SFB) in the field of cancer therapy is being realized thanks to new research that offers insights into the multi-targeting therapeutic mechanisms and key signaling pathways. The pharmacological effects of SFB against various cancers in vitro and in vivo are reviewed in this review. In addition, the types and characteristics of biflavonoid structures are described in detail; we also provide a brief summary of the efforts to develop drug delivery systems or combinations to enhance the bioavailability of SFB monomers. In conclusion, SFB species have great potential to be developed as adjuvant or even primary therapeutic agents for cancer, with promising applications.

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Siamenflavones A-C, three undescribed biflavonoids from Selaginella siamensis Hieron. and biflavonoids from spike mosses as EGFR inhibitor

Cited by 7 publications

References 70 publications

Sesquiterpenoids isolated from the rhizome of Curcuma phaeocaulis Valeton: antitumor activity, in silico molecular docking and molecular dynamics study

Sesquiterpenoids isolated from the rhizome of Curcuma phaeocaulis Valeton: antitumor activity, in silico molecular docking and molecular dynamics study

A chemistry overview of the beautiful miniature forest known as mosses

Advances in the Anti-Tumor Activity of Biflavonoids in Selaginella

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