Should milk-specific IgE antibodies be measured in adults in primary care?

Anthoni, Sari; Elg, Peter; Haahtela, Tari; Kolho, Kaija‐Leena

doi:10.1080/02813430802117442

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…In our previous study, we showed that IgE antibodies to milk did not correlate with the self-reported, milkrelated symptoms [5] . Consistent with this, Pelto et al [11] have shown that hypersensitivity to cow's milk does also occur in adults but the mechanism is most likely not milk-specific antibody-mediated but rather due to an increase in serum reactivity to milk protein.…”

Section: Discussionmentioning

confidence: 99%

“…Milk hypersensitivity in early childhood is mostly milk protein IgE-mediated [3,4] causing immediatetype hypersensitivity reactions. The frequency of IgEmediated cow's milk allergy decreases with increasing age and a high level of cow's milk-specific IgE is rare in adults [5][6][7][8] . The impact of other types of immune reactions to cow's milk and, more specifically, the association of antibodies of IgG and IgA isotypes with cow's milk-induced adverse gastrointestinal symptoms in adults, is presently controversial [9][10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

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Milk protein IgG and IgA: The association with milk-induced gastrointestinal symptoms in adults

Anthoni¹,

Savilahti²,

Rautelin³

et al. 2009

WJG

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AIM:To study the association between serum levels of milk protein IgG and IgA antibodies and milk-related gastrointestinal symptoms in adults. METHODS:Milk protein IgG and IgA antibodies were determined in serum samples of 400 subjects from five outpatient clinics in Southern Finland. Subjects were randomly selected from a total of 1900 adults undergoing laboratory investigations in primary care. All 400 participants had completed a questionnaire on abdominal symptoms and dairy consumption while waiting for the laboratory visit. The questionnaire covered the nature and frequency of gastrointestinal problems, the provoking food items, family history and allergies. Twelve serum samples were disqualified due to insufficient amount of sera. The levels of specific milk protein IgG and IgA were measured by using the ELISA technique. The association of the milk protein-specific antibody level was studied in relation to the milk-related gastrointestinal symptoms and dairy consumption. RESULTS:Subjects drinking milk (n = 265) had higher levels of milk protein IgG in their sera than non-milk drinkers (n = 123, P < 0.001). Subjects with gastrointestinal problems related to milk drinking (n = 119) consumed less milk but had higher milk protein IgG levels than those with no milk-related gastrointestinal symptoms (n = 198, P = 0.02). Among the symptomatic subjects, those reporting dyspeptic symptoms had lower milk protein IgG levels than non-dyspeptics (P < 0.05). However, dyspepsia was not associated with milk drinking (P = 0.5). The association of high milk protein IgG levels with constipation was close to the level of statistical significance. Diarrhea had no association with milk protein IgG level (P = 0.5). With regard to minor symptoms, flatulence and bloating (P = 0.8), were not associated with milk protein IgG level. Milk protein IgA levels did not show any association with milk drinking or abdominal symptoms. The levels of milk protein IgA and IgG declined as the age of the subjects increased (P < 0.004). CONCLUSION:Milk protein IgG but not milk IgA seems to be associated with self-reported milk-induced gastrointestinal symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Milk protein IgG and IgA: The association with milk-induced gastrointestinal symptoms in adults

Anthoni¹,

Savilahti²,

Rautelin³

et al. 2009

WJG

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“…The rate of IgE-mediated CMPA decreases while other non-IgE-mediated CMPA increases with increasing age. High cow’s milk-specific IgE levels are rare in adults[ 13 ]. CMPA may manifest as an isolated gut reaction or be associated with other systemic manifestations such as skin, respiratory, or cardiovascular manifestations.…”

Section: Cow’s Milk Protein Allergymentioning

confidence: 99%

Cow’s milk-induced gastrointestinal disorders: From infancy to adulthood

Al‐Biltagi¹,

Saeed²,

Bediwy³

et al. 2022

World J Clin Pediatr

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Milk is related to many gastrointestinal disorders from the cradle to the grave due to the many milk ingredients that can trigger gastrointestinal discomfort and disorders. Cow’s milk protein allergy (CMPA) is the most common food allergy, especially in infancy and childhood, which may persist into adulthood. There are three main types of CMPA; immunoglobulin E (IgE)-mediated CMPA, non-IgE-mediated CMPA, and mixed type. CMPA appears before the first birthday in almost all cases. Symptoms may start even during the neonatal period and can be severe enough to simulate neonatal sepsis. CMPA (often non-IgE mediated) can present with symptoms of gastroesophageal reflux, eosinophilic esophagitis, hemorrhagic gastritis, food protein-induced protein-losing enteropathy, and food protein-induced enterocolitis syndrome. Most CMPAs are benign and outgrown during childhood. CMPA is not as common in adults as in children, but when present, it is usually severe with a protracted course. Lactose intolerance is a prevalent condition characterized by the development of many symptoms related to the consumption of foods containing lactose. Lactose intolerance has four typical types: Developmental, congenital, primary, and secondary. Lactose intolerance and CMPA may be the underlying pathophysiologic mechanisms for many functional gastrointestinal disorders in children and adults. They are also common in inflammatory bowel diseases. Milk consumption may have preventive or promoter effects on cancer development. Milk may also become a source of microbial infection in humans, causing a wide array of diseases, and may help increase the prevalence of antimicrobial resistance. This editorial summarizes the common milk-related disorders and their symptoms from childhood to adulthood.

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