Short-term prognostic factors in myelomeningocele patients

Rodrigues, Andre Broggin Dutra; Krebs, Vera Lúcia Jornada; Matushita, Hamilton; Carvalho, Werther Brunow de

doi:10.1007/s00381-016-3012-7

Cited by 24 publications

(20 citation statements)

References 26 publications

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“…It was determined that early mortality and morbidity rates decreased in the babies with NTD in the early period. In the literature, 70–91% of newborns diagnosed for meningomyelocele were operated in the first 72 hr (Bülbül et al, ; Rodrigues, Krebs, Matushita, & de Carvalho, ). Bulbul et al found that duration of hospitalization and central nervous system (CNS) infection rate was significantly lower in babies undergone operations due to meningomyelocele in the first 3 days (Bülbül et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Bulbul et al found that duration of hospitalization and central nervous system (CNS) infection rate was significantly lower in babies undergone operations due to meningomyelocele in the first 3 days (Bülbül et al, ). Rodrigues et al found that the risk of SSS infection was 5.72 times less in babies undergone operations in the first 48 hr (Rodrigues et al, ). Therefore, it is recommended that the operation for the improvement of NTD should be performed within the first 72 hr.…”

Section: Discussionmentioning

confidence: 99%

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Short‐term results of patients with neural tube defects followed‐up in the Konya region, Turkey

Yorulmaz

Konak

2019

Birth Defects Research

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Background: Additional congenital anomalies have often been found in patients with neural tube defect (NTD). We aimed to find out the clinical features, short term prognosis, treatment approaches, and systemic anomalies of NTD patients in the Konya region. Method: A total of 186 newborn babies with NTD were retrospectively included in the study and all were assessed in detail for congenital anomalies and clinical features. Results: When the application month of the patients was examined, it was seen that the most frequent month was July. Of 186 babies, 101(54.3%) had meningomyelocele, 53 (28.5%) had meningocele, 13 (7.0%) had encephalocele, 16 (8.6%) had spina bifida occulta, and 4 (2.1%) had anencephaly. Of these patients, 97 (52.2%) were male and 89 (47.8%) were female. Hydrocephalus was an almost constant finding and was found in 140 (75.3%) patients. 51 (27.4%) patients had congenital heart disease (CHD). The most common CHD was atrial septal defect 22.3%. Orthopedic anomaly was detected in 51 (27.4%) patients, nephrological anomaly was found in 47 (25.3%) of the cases, congenital hypothyroidism was diagnosed in 14 (7.5%) patients with NTD. The mortality rate of patients diagnosed with NTD was 7.5%. The rates of premature delivery and consanguinity between parents were higher in patients with NTD. Conclusions: Our results indicate that at least one congenital anomaly is also present in about two-thirds of newborn babies with NTD, and these anomalies significantly increase their morbidity and mortality. All newborn babies with NTD should be screened for additional congenital anomalies and evaluated with more organized, multidisciplinary methods. K E Y W O R D Scongenital anomalies, congenital hypothyroidism, folic acid, hydrocephalus, neural tube defect

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Short‐term results of patients with neural tube defects followed‐up in the Konya region, Turkey

Yorulmaz

Konak

2019

Birth Defects Research

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“…Surgical site infection is a frequent complication in myelomeningocele repair [12]. The prevalence of wound sepsis in this series was 21% which falls within the 12.8-34% reported in the literature [11,12,16,23]. Risk factors for surgical site infection are delayed presentation, size of defect, length of operative procedure and the use of flap reconstruction [11,12].…”

Section: Discussionmentioning

confidence: 71%

A perspective in the management of myelomeningocoele in the KwaZulu-Natal Province of South Africa

2020

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Background Myelomeningocoele (MMC) is common in the developing world. The purpose of this study was to investigate the clinical characteristics and management of myelomeningocoele and to identify factors contributing to outcomes. Methods This was a retrospective, observational study of consecutive children diagnosed with MMC managed in the Paediatric Neurosurgery Unit at Inkosi Albert Luthuli Central Hospital. Multiple logistic regression analysis identified clinical characteristics, demographics and surgical variables that were associated with outcome. Results A total of 309 children were managed during this period (M:F 1.3:1). The most common sites were lumbar, lumbo-sacral and sacral. Mean age at surgical repair was 4.7 ± 15.6 months. Two hundred and eight children had ventriculomegaly, of whom 158 had symptomatic hydrocephalus, requiring CSF diversion. Fifty-eight (21%) patients developed wound sepsis, of whom 13 (22%) developed meningitis (p = 0.001). The time to wound sepsis was 9.5 ± 3.6 days. The commonest organism isolated was Staphylococcus aureus followed by MRSA. Thirty-two patients (23%) developed shunt malfunction and three (11%) developed ETV malfunction. Twenty children (9%) demised during the admission period. Death was associated with meningitis (p < 0.0001), and meningitis itself was associated with wound sepsis (p < 0.0001). Hospital stay was 20.4 ± 16 days. Wound sepsis (p = 0.002) and meningitis (p < 0.0001), respectively, were associated with prolonged hospital stay. Conclusion There was a slight male preponderance and hydrocephalus occurred in two thirds of cases. Wound sepsis and meningitis were associated poor outcomes.

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“…In the study by Bulbul et al 6 , it was found that the length of hospital stay and the rate of CNS infections were significantly lower in newborns operated on due to myelomeningocele within the first 3 days of life. In the study by Rodrigues et al 32 , the risk of developing CNS infections was found to be 5.72-fold lower in newborns operated on within the first 48 hours. In our study, 62.65% of patients were operated on within the first month of life, and this rate is consistent with that observed in the literature 21,32 .…”

Section: Study Of Hokkaido Did Not Reveal Any Relation Between Serum mentioning

confidence: 89%

Comorbid Conditions in Newborn Operated Due to Open Spinal Dysraphism and Retrospective Evaluation of Relation Between These Situations with Folic Acid Usage During the Pregnancy

Çetin¹,

Yektaş²

2018

Kafkas J Med Sci

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Aim: In the present study, we aimed to analyze comorbid conditions associated with operated myelomeningocele and their relationship with folic acid usage during pregnancy. Material and Method: Eighty-one newborns who were operated on due to myelomeningocele were included in this study. The patient's files were retrospectively reviewed, and the data of the patients were recorded. The patients were divided into two groups: folic acid users and non-folic acid users during pregnancy. The two groups were compared in terms of weight, height, hemogram, biochemistry, time of diagnosis, delivery method, maturity, localization, type (meningocel or myelomeningocel), neurological deficit, scoliosis, hydrocephalus, timing of surgery, ventriculomegaly, treatment method, additional pathology, tethered cord syndrome, dermal sinus, maternal disease, and number of malformations such as cerebrospinal fluid fistula. Results: The rate of folic acid usage during the antenatal period was 44.4%. Myelomeningocele was located in lumbar (40.7%) and sacral (46.9%) regions. The rate of operation with early diagnosis newborn (1

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Short-term prognostic factors in myelomeningocele patients

Cited by 24 publications

References 26 publications

Short‐term results of patients with neural tube defects followed‐up in the Konya region, Turkey

Short‐term results of patients with neural tube defects followed‐up in the Konya region, Turkey

A perspective in the management of myelomeningocoele in the KwaZulu-Natal Province of South Africa

Comorbid Conditions in Newborn Operated Due to Open Spinal Dysraphism and Retrospective Evaluation of Relation Between These Situations with Folic Acid Usage During the Pregnancy

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