Short-term periradicular tissue response to mineral trioxide aggregate (MTA) as root-end filling material

Economides, Nikolaos; Pantelidou, Ourania; Κόκκας, Ανδρέας; Tziafas, Dimitrios

doi:10.1046/j.0143-2885.2003.00611.x

Cited by 125 publications

(114 citation statements)

References 9 publications

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“…In 53-month radiography, scar tissue can be found associated with a partial apical bone formation with the integrity of the lamina dura. This fact relates to histological findings that show the deposition of cementum on MTA retro-fillings (15).…”

Section: Discussionsupporting

confidence: 53%

Therapeutic Approach to Pulp Canal Calcification as Sequelae of Dental Avulsion

Moura¹,

Velasques²,

Silveira³

et al. 2017

Eur Endod J

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Tooth avulsion represents the most complicated dental injury, and the classic treatment is tooth replantation. The most common sequelae are pulp canal calcification (PCC) and pulp necrosis. The presence of pulp necrosis after PCC is reported in up to 30% of the cases and is a challenge due to the difficulty of endodontic treatment. This case report describes the surgical treatment of a replanted tooth presenting PCC and periapical pathology eight years after the trauma. An endodontic surgery was performed to remove the apical granuloma, to prepare the apical root, and to seal the apical region with an endodontic cement. In a three-year follow-up, there was an absence of inflammatory signs and symptoms or apical lesion. This report shows the importance of close follow-up after dentoalveolar injuries. After the initial dental trauma and its consequences to pulpal tissues, the executed procedures allowed a favourable outcome.

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Section: Discussionsupporting

confidence: 53%

Therapeutic Approach to Pulp Canal Calcification as Sequelae of Dental Avulsion

Moura¹,

Velasques²,

Silveira³

et al. 2017

Eur Endod J

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“…Cementum-like tissue formation on the resected dentinal surface and mineral trioxide aggregate has been reported 30,[33][34][35][36] . In the present study, cementum-like tissue deposition was observed on the resected dentinal 6,9,10) , although a gradual increase in leakage over long periods has also been reported 12) .…”

Section: Discussionmentioning

confidence: 98%

Healing of experimental apical periodontitis after apicoectomy using different sealing materials on the resected root end

et al. 2011

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This study evaluated apical periodontal healing after root-end sealing using 4-META/MMA-TBB resin (SB), and root-end filling using reinforced zinc oxide eugenol cement (EBA) or mineral trioxide aggregate (MTA) when root canal infection persisted. Apical periodontitis was induced in mandibular premolars of beagles by contaminating the root canals with dental plaque. After 1 month, in the SB group, SB was applied to the resected surface following apicoectomy. In the EBA and MTA groups, a root-end cavity was prepared and filled with EBA or MTA. In the control group, the root-end was not filled. Fourteen weeks after surgery, histological and radiographic analyses in a beagle model were performed. The bone defect area in the SB, EBA and MTA groups was significantly smaller than that in the control group. The result indicated that root-end sealing using SB and root-end filling using EBA or MTA are significantly better than control.

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“…Choosing human periodontal ligament fibroblasts presents the additional advantage of reducing bias concerning species origin and non-tissue specific cell lines (17). Therefore, the choice for cultured human periodontal ligament fibroblasts for the present study is justified by the close relation of endodontic sealers and cements to the periapical tissues (18).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Cytotoxicity of White MTA, MTA Fillapex® and Portland Cement on Human Periodontal Ligament Fibroblasts

et al. 2013

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The aim of this study was to compare the in vitro cytotoxicity of white mineral trioxide aggregate (MTA), MTA Fillapex ® and Portland cement (PC) on human cultured periodontal ligament fibroblasts. Periodontal ligament fibroblast culture was established and the cells were used for cytotoxic tests after the fourth passage. Cell density was set at 1.25 x10 4 cells/well in 96-well plates. Endodontic material extracts were prepared by placing sealer/ cement specimens (5x3mm) in 1mL of culture medium for 72 h. The extracts were then serially two-fold diluted and inserted into the cell-seeded wells for 24, 48 and 72 h. MTT assay was employed for analysis of cell viability. Cell supernatants were tested for nitric oxide using the Griess reagent system. MTA presented cytotoxic effect in undiluted extracts at 24 and 72 h. MTA Fillapex ® presented the highest cytotoxic levels with important cell viability reduction for pure extracts and at ½ and ¼ dilutions. In this study, PC did not induce alterations in fibroblast viability. Nitric oxide was detected in extract-treated cell supernatants and also in the extracts only, suggesting presence of nitrite in the soluble content of the tested materials. In the present study, MTA Fillapex displayed the highest cytotoxic effect on periodontal ligament fibroblasts followed by white MTA and PC.

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Short-term periradicular tissue response to mineral trioxide aggregate (MTA) as root-end filling material

Abstract: MTA is a biocompatible material that stimulates periradicular tissue repair at the root-end situation; however, the nature of the newly formed tissues requires further elucidation.

Cited by 125 publications

References 9 publications

Therapeutic Approach to Pulp Canal Calcification as Sequelae of Dental Avulsion

Therapeutic Approach to Pulp Canal Calcification as Sequelae of Dental Avulsion

Healing of experimental apical periodontitis after apicoectomy using different sealing materials on the resected root end

In Vitro Cytotoxicity of White MTA, MTA Fillapex® and Portland Cement on Human Periodontal Ligament Fibroblasts

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