Healing of experimental apical periodontitis after apicoectomy using different sealing materials on the resected root end

Otani, Kaori; Sugaya, Tsutomu; Tomita, Mahito; Hasegawa, Yukiko; Miyaji, Hirofumi; Tenkumo, Taichi; Tanaka, Saori; Motoki, Youji; Takanawa, Yasuhiro; Kawanami, Masamitsu

doi:10.4012/dmj.2010-158

Cited by 25 publications

(23 citation statements)

References 38 publications

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“…Mineral Trioxide Aggregate (MTA) is a dental material widely used for root perforation repair, retrograde filling and teeth with open apices 1) . MTA has proper physicochemical properties, sealing capacity, biocompatibility, and ability to induce bone mineralization [2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Radiopacity, pH and antimicrobial activity of Portland cement associated with micro- and nanoparticles of zirconium oxide and niobium oxide

et al. 2014

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The aim of this study was to evaluate some properties of the calcium silicate materials Mineral Trioxide Aggregate (MTA) and Portland cement (PC) with microparticulated (micro) and nanoparticulated (nano) zirconium oxide (ZrO 2 ) or niobium oxide (Nb 2 O 5 ). The experimental materials: White PC (PC), MTA-Angelus ® (MTA), PC+ZrO 2 micro, PC+ZrO 2 nano, PC+Nb 2 O 5 micro and PC+Nb 2 O 5 nano were submitted to radiopacity and pH evaluations. Furthermore, the antimicrobial activity against different microorganisms was assessed by agar diffusion test. MTA presented higher radiopacity than other materials. However, all materials except PC presented higher radiopacity than recommended by ISO/ADA. MTA promoted higher pH values in all analyzed periods (p≤0.05). At the initial periods, PC and PC+ZrO 2 micro showed pH similar to MTA. All materials showed antimicrobial activity against the evaluated microorganisms. In conclusion, ZrO 2 and Nb 2 O 5 could be alternative radiopacifiers to be added to calcium silicate materials.

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Section: Introductionmentioning

confidence: 99%

Radiopacity, pH and antimicrobial activity of Portland cement associated with micro- and nanoparticles of zirconium oxide and niobium oxide

et al. 2014

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“…Tri-n-butyl borane (TBB), a polymerization initiator of SB, is known to promote radical formation in the presence of water, permitting high polymerization of SB under conditions of poor moisture control 6,23) and greater bonding effectiveness than other adhesives in wet environments 11) . Additionally, SB provides a favorable surface for cell attachment 12) , meaning it can be directly applied to soft tissues in procedures such as direct pulp capping [8][9][10] .…”

Section: Discussionmentioning

confidence: 99%

“…The application of dental adhesive resins is expanding to include various treatments such as the restoration of fractured roots [1][2][3][4] , root-end fillings 5,6) , and perforation sealing 7) . Among a plethora of adhesive resins, those based on 4-methacryloxyethyl trimellitate anhydride (4-META)/methyl methacrylate (MMA) exhibit high biocompatibility with the periodontal tissues and excellent bonding and sealing capabilities in wet conditions 3,4,[8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Influence of polymerization properties of 4-META/MMA-based resin on the activity of fibroblast growth factor-2

et al. 2017

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Dental adhesive resins based on 4-methacryloxyethyl trimellitate anhydride (4-META)/methyl methacrylate (MMA) have been utilized for root-end filling and the bonding of fractured roots. To increase the success rate of these treatments, it would be beneficial to promote the healing of surrounding tissue by applying growth factors. In this study, the influences of the polymerization properties of 4-META/MMA-based resins on the activity of fibroblast growth factor-2 (FGF-2) were evaluated in vitro. The temperature increase caused by the heat generation during polymerization of the 4-META/MMA-based resin was insufficient to change the structure and function of FGF-2. Unpolymerized monomers released from the cured 4-META/MMA-based resin had no negative influences on the ability of FGF-2 to promote the proliferation of osteoblast-like cells. These findings suggest that it is possible to use FGF-2 in combination with 4-META/MMA-based resins.

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“…MTA is a type of calcium silicate cement and is used for various treatments such as direct pulp capping, root-end filling, root canal filling, perforation repair, and apexogenesis 37,38) . However, the application of dental adhesive resins is also expanding to include various treatments such as restoration of fractured roots [39][40][41][42] , root-end fillings 43) , or perforation sealing 44) . Among a plethora of dental adhesive resins, a 4-methacryloxyethyl trimellitate anhydride (4-META)/methyl methacrylate (MMA)-based resin is highly biocompatible, and exhibits excellent bonding and sealing capabilities in wet conditions 45) .…”

Section: Application Of Fgf-2-loaded Polymer Particles To Restorativementioning

confidence: 99%

Non-biodegradable polymer particles for drug delivery: A new technology for “bio-active” restorative materials

Imazato

Kitagawa

Tsuboi

et al. 2017

Dental Materials Journal

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To develop dental restorative materials with "bio-active" functions, addition of the capability to release active agents is an effective approach. However, such functionality needs to be attained without compromising the basic properties of the restorative materials. We have developed novel non-biodegradable polymer particles for drug delivery, aimed for application in dental resins. The particles are made using 2-hydroxyethyl methacrylate (HEMA) and a cross-linking monomer trimethylolpropane trimethacrylate (TMPT), with a hydrophilic nature to adsorb proteins or water-soluble antimicrobials. The polyHEMA/TMPT particles work as a reservoir to release fibroblast growth factor-2 (FGF-2) or cetylpyridinium chloride (CPC) in an effective manner. Application of the polyHEMA/ TMPT particles loaded with FGF-2 to adhesives, or those loaded with CPC to resin-based endodontic sealers or denture bases/crowns is a promising approach to increase the success of the treatments by conferring "bio-active" properties to these materials to induce tissue regeneration or to inhibit bacterial infection.

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Healing of experimental apical periodontitis after apicoectomy using different sealing materials on the resected root end

Cited by 25 publications

References 38 publications

Radiopacity, pH and antimicrobial activity of Portland cement associated with micro- and nanoparticles of zirconium oxide and niobium oxide

Radiopacity, pH and antimicrobial activity of Portland cement associated with micro- and nanoparticles of zirconium oxide and niobium oxide

Influence of polymerization properties of 4-META/MMA-based resin on the activity of fibroblast growth factor-2

Non-biodegradable polymer particles for drug delivery: A new technology for “bio-active” restorative materials

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