Non-biodegradable polymer particles for drug delivery: A new technology for “bio-active” restorative materials

Imazato, Satoshi; Kitagawa, Haruaki; Tsuboi, Ririko; Kitagawa, Ranna; Thongthai, Pasiree; Sasaki, Junichi

doi:10.4012/dmj.2017-156

Cited by 25 publications

(21 citation statements)

References 63 publications

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“…Previous studies found it more effective than individual components. Other antibacterial agents like triclosan and cationic agents were also loaded [103]. What's more, to reduce the inflammatory response of pulp caused by deep dental caries, anti-inflammatory agents such as indomethacin have also been combined in the dental resin [104].…”

Section: Dds For Secondary Cariesmentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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Section: Dds For Secondary Cariesmentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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“…Another approach to providing restorative materials with long-lasting antimicrobial effects is to apply non-biodegradable polymer particles as a reservoir of antimicrobials 2) . Imazato et al developed non-biodegradable polymer particles made of hydrophilic monomer 2-hydroxyethyl methacrylate (HEMA) and a cross-linking monomer trimethylolpropane trimethacrylate (TMPT) 2) ( Fig.…”

Section: Polymer Particles As a Reservoir Of Antimicrobialsmentioning

confidence: 99%

“…The basic mechanical, physical, esthetic, and bonding properties of dental restorative/coating materials have greatly improved with technological developments, and the current materials on the market show excellent clinical performance. Therefore, the target of their advancement is shifting towards bio-active functionality to prevent primary/secondary diseases or promote tissue regeneration 1,2) . Several properties are considered to be useful bio-active functions for dental materials.…”

Section: Introductionmentioning

confidence: 99%

“…Several properties are considered to be useful bio-active functions for dental materials. These involve the addition of bio-protective effects, such as control of bacterial infection or strengthening of the tooth substrate, and the conferring of bio-promoting effects, such as remineralization, control of inflammation, or promotion of tissue regeneration 2) .…”

Section: Introductionmentioning

confidence: 99%

“…Considering the diverse functions exhibited by various kinds of ions, several restorative or coating materials incorporating glass fillers with multiple ion-releasing effects have been commercialized and are in clinical use 1,6) . Another technology of interest is a new filler made of non-biodegradable polymer particles 2) , which work as a reservoir to release not only chemicals but also proteins, and can be incorporated into restorative/prosthetic materials.…”

Section: Introductionmentioning

confidence: 99%

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Cutting-edge filler technologies to release bio-active components for restorative and preventive dentistry

et al. 2020

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Advancements in materials used for restorative and preventive treatment is being directed toward "bio-active" functionality. Incorporation of filler particles that release active components is a popular method to create bio-active materials, and many approaches are available to develop fillers with the ability to release components that provide "bio-protective" or "bio-promoting" properties; e.g. metal/calcium phosphate nanoparticles, multiple ion-releasing glass fillers, and non-biodegradable polymer particles. In this review paper, recent developments in cutting-edge filler technologies to release bio-active components are addressed and summarized according to their usefulness and functions, including control of bacterial infection, tooth strengthening, and promotion of tissue regeneration.

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Drug Delivery Systems and Oral Biofilm

Ceniceros¹,

González²,

Tijerina³

et al. 2023

Advances in Novel Formulations for Drug Delivery

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Non-biodegradable polymer particles for drug delivery: A new technology for “bio-active” restorative materials

Cited by 25 publications

References 63 publications

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Cutting-edge filler technologies to release bio-active components for restorative and preventive dentistry

Drug Delivery Systems and Oral Biofilm

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