Short-Term Feeding of Fibre-Enriched Biscuits: Protective Effect against Hepatotoxicity in Diabetic Rats

Erukainure, Ochuko L.; Ebuehi, Osaretin Albert Taiwo; Adeboyejo, Folasade Olabimpe; Oladunmoye, Olufunmilola Olaitan; Muhammad, Aliyu; Obode, Okukwe C.; Olasehinde, Tosin A.; Elemo, Gloria N.

doi:10.1155/2015/868937

Cited by 16 publications

(13 citation statements)

References 31 publications

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“…26 High concentration of AST and ALT indicates tissue damage and altered membrane permeability. 27 This suggests that the aqueous extract did not induce hepatic damage as no significant difference was observed in ALT and AST levels of the test and control groups. Furthermore, proteins aid the maintenance of osmotic pressure of body fluids and transport of inorganic anions, fatty acids, and drugs.…”

Section: Discussionmentioning

confidence: 84%

Toxicological Effects of Aqueous Extract From African Walnut (Tetracarpidium conophorum) Leaves in Rats

Akomolafe

Oboh

Oyeleye

et al. 2017

J Evid Based Complementary Altern Med

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Tetracarpidium conophorum leaves are used in traditional medicine for the treatment of male infertility, without considering its toxicity and side effects. In this study, we investigated the effects of T conophorum leaves on some biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, bilirubin, albumin, creatinine, and uric acid. Histology of the liver and kidney were also assessed. The result revealed that the alanine aminotransferase and aspartate aminotransferase levels of the control group were not significantly different from the experimental groups. There was no significant difference in the albumin and bilirubin levels of the control and experimental groups. Similarly, the uric acid and creatinine levels of the experimental rats were not significantly different from the control. The examination of liver and kidney sections did not show any morphological changes and inflammatory cell infiltrations. These findings suggest that the leaves did not induce any pathological changes at the doses tested.

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Section: Discussionmentioning

confidence: 84%

Toxicological Effects of Aqueous Extract From African Walnut (Tetracarpidium conophorum) Leaves in Rats

Akomolafe

Oboh

Oyeleye

et al. 2017

J Evid Based Complementary Altern Med

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“…[ 49 ] Elevated concentration of ALT and AST indicates altered membrane permeability and tissue damage. [ 50 ] No significant difference was observed in serum ALT and AST levels among the treatments. This implies that the inclusion of TSCM did not induce hepatic damage in broiler chickens.…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of Tetracarpidium conophorum (African Walnut) Seed Enhances Muscle n‐3 Fatty Acids in Broiler Chickens

Adeyemi

Abdulrahman

Ibrahim

et al. 2020

Euro J Lipid Sci & Tech

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The influence of dietary Tetracarpidium conophorum (African Walnut) seed meal (TCSM) on fatty acids, productivity parameters, and physicochemical properties of breast and thigh muscles in broiler chickens are assessed. A total of 180, 28-d-old Arbor acre broiler chickens are randomly assigned to dietary treatments containing 0% (control), 2.5%, and 5% w/w TCSM, fed for 28 d, and euthanized. Dietary TCSM reduces (p < 0.05) feed intake, body weight gain (BWG), carcass weight, and abdominal fat. Diet does not affect feed efficiency and hematological parameters. The control birds have higher (p < 0.05) serum total cholesterol and triglycerides than do the supplemented birds. Diet has no effect on pH, water holding capacity, carbonyl and malondialdehyde contents, and organoleptic properties of breast and thigh muscles. The 5% TCSM has higher redness in breast muscle than do other treatments. Dietary TCSM improves (p < 0.05) the concentration of C18:3n-3 (4.80-8.76% vs 1.56%), C20:5n-3 (0.54-0.79% vs 0.39%), C22:5n-3 (0.64-0.89% vs 0.18%), and C22:6n-3 (0.75-0.97% vs 0.19%), and reduces (p < 0.05) the fat content (2.15-2.45% vs 3.15%) in breast and thigh muscles. Dietary TCSM enhances muscle n-3 fatty acids without instigating oxidative deterioration, but reduces BWG in broiler chickens. Practical Application: Albeit that broiler meat is rich in polyunsaturated fatty acids (PUFA), its omega 6 (n-6)/omega 3 (n-3) is >4. Elevated n-6/n-3 could have adverse effect on human physiology thereby promoting the pathogenesis of certain diseases. This heightens the need to enhance the n-3 PUFA content of broiler meat. Dietary TCSM induced up to a fourfold increase in n-3 PUFA content of the breast and thigh muscles in broiler chickens. Moreover, dietary TCSM induced up to a tenfold decrease in the n-6/n-3 of the breast and thigh muscles in broiler chickens. This finding assumes great significance because the health concerns regarding dietary fat are the foremost factors responsible for the bad image suffered by meat. These results provide insights on the potential of TCSM to improve the nutritional quality without compromising the oxidative shelf life, organoleptic traits, and physicochemical properties of broiler meat.

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“…Hepatotoxicity and nephrotoxicity have been reported as major complications of T2D owing to insulin resistance and oxidative damage ( Vozarova et al, 2002 ). They are characterized by increased serum levels of hepatic and renal enzymes due to inflammation of the tissues ( Erukainure et al, 2015 ). The increased levels in the diabetic rats (group 2) portrays incidences of hepatotoxicity and nephrotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Suppressive Effects of Clerodendrum volubile P Beauv. [Labiatae] Methanolic Extract and Its Fractions on Type 2 Diabetes and Its Complications

et al. 2018

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Type 2 diabetes is the most prominent of all diabetes types, contributing to global morbidity and mortality. Availability and cost of treatment with little or no side effect especially in developing countries, remains a huge burden. This has led to the search of affordable alternative therapies especially from medicinal plants. In this study, the antidiabetic effect of the methanolic extract, dichloromethane (DCM), butanol (BuOH) and aqueous fractions of Clerodendrum volubile leaves were investigated in type 2 diabetic rats for their effect on glucose homeostasis, serum insulin level and hepatic biomarkers, lipid profile, pancreatic redox balance and Ca2+ levels, and β-cell distribution and function. The DCM was further fractionated to isolate the active compounds, biochanin and 5,7,4′-trimethoxykaempferol. They were investigated for their toxicity and ADMET properties, α-glucosidase and angiotensin I converting enzyme (ACE) inhibitory activities in silico. There were significant (p < 0.05) decrease in blood glucose, cholesterol, LDL-C, vLDL-C, triglyceride, AST and ALT levels in all treated groups, with DCM fraction showing the best activity. All treated rats showed significantly (p < 0.05) improved anti-oxidative activities. Treatment with the DCM fraction led to significant (p < 0.05) increased serum insulin and pancreatic Ca2+ levels, as well as improved β-cell distribution and function. DCM fraction also showed improved glucose tolerance. DCM fraction dose-dependently inhibited ACE activity. The toxicity class of the isolated compounds was predicted to be 5. They were also predicted to be potent inhibitors of cytochrome P (CYPs) 1A2, 2D6 and 3A4. They docked well with α-glucosidase and ACE. These results indicate the therapeutic potential of the plant against type 2 diabetes, with the DCM fraction being the most potent which may be attributed to the isolated flavones. It further suggests antihypertensive potentials of the DCM fraction. However, inhibition of CYPs by the flavones may suggest caution in usage with other prescribed drugs metabolized by these enzymes.

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Short-Term Feeding of Fibre-Enriched Biscuits: Protective Effect against Hepatotoxicity in Diabetic Rats

Cited by 16 publications

References 31 publications

Toxicological Effects of Aqueous Extract From African Walnut (Tetracarpidium conophorum) Leaves in Rats

Toxicological Effects of Aqueous Extract From African Walnut (Tetracarpidium conophorum) Leaves in Rats

Dietary Supplementation of Tetracarpidium conophorum (African Walnut) Seed Enhances Muscle n‐3 Fatty Acids in Broiler Chickens

Suppressive Effects of Clerodendrum volubile P Beauv. [Labiatae] Methanolic Extract and Its Fractions on Type 2 Diabetes and Its Complications

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