Short PET in pediatric peritoneal dialysis

Cuevas, Monica Caba; Zambrano, Pedro; Dinamarca, H.; Gilbert, M Thomas P; Cano, Francisco

doi:10.1007/s00467-008-0892-0

Cited by 6 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors found that in all patients, the peritoneal transport categories were the same using PET values at 2 and 4 h of the procedure. Later on, in 2007, we conducted another retrospective evaluation of the short PET in 81 patients from two different local medical centers [16] and found no significant correlation between values at 2 and 4 h, suggesting that the use of the short test was not reliable enough to estimate the transport capacity of the peritoneal membrane in a pediatric population.…”

Section: Discussionmentioning

confidence: 93%

“…These authors concluded that short PET was sufficiently reliable to replace the 4-h version, without meaning a change in the depuration or ultrafiltration category of the patient. Later on, we published a retrospective PET experience in 81 patients, showing a weak concordance between the 2 and 4-h PET results [16]. Therefore, current recommendations are based on retrospective experiences with controversial results.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

The short peritoneal equilibration test in pediatric peritoneal dialysis

Cano¹,

Sanchez²,

Rébori³

et al. 2010

Pediatr Nephrol

Self Cite

View full text Add to dashboard Cite

The peritoneal equilibration test (PET) is the gold standard method for defining peritoneal membrane permeability and for prescribing peritoneal dialysis (PD) therapy on an individual basis. However, it is laborious, consumes nursing time, and requires many hours to be performed. Therefore, several authors have attempted to validate a short PET protocol, with controversial results. To evaluate the concordance between the 2-h (short) and 4-h (classical) peritoneal equilibrium test, a prospective observational protocol was applied in three PD centers (Mexico, Chile, and Uruguay) between July 1, 2008 and July 31 2009. PET protocol: the night prior to the test, each patient received five exchanges, 1 h each, at the same glucose concentration as previously used. Afterwards, a 2.5% glucose dialysis solution was used for a dwell time of 4 h. Exchange fill volume was 1,100 ml/m2 body surface area. The next morning, the 4-h dwell was drained, and Dianeal 2.5% was infused. Three dialysate samples at 0, 2, and 4 h were obtained. A single blood sample was obtained at 120 min. Creatinine D/P and glucose D/D0 ratios were calculated at hours 0, 2, and 4. Patients were categorized as low, low average, high average, or high transporters according creat D/P and gluc D/D0 results. Pearson and Kappa test were used for numerical and categorical correlations, respectively, and p<0.05 was considered significant. Eighty-seven PET studies were evaluated in 74 patients, 33 males, age 11.1+/-5.05 years old. A positive linear correlation of 92% between 2 and 4-h creat D/P and 80% between 2 and 4-h gluc D/D0 (p<0.001) was founded. The Kappa test showed a significant concordance between creat D/P and gluc D/D0 categories at 2 and 4 h (p<0.001). When analyzing cut-off-value categories, creat D/P was founded to be lower and gluc D/D0 higher than other experiences. This multicentric prospective study strongly suggests that PET obtained at 2 h and 4 h, based on either creatinine or glucose transport, provides identical characterization of peritoneal membrane transport capacity in PD children.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 98%

The short peritoneal equilibration test in pediatric peritoneal dialysis

Cano¹,

Sanchez²,

Rébori³

et al. 2010

Pediatr Nephrol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cuevas et al (16) conducted a prospective study of the results of 81 PET tests in 81 patients. They analyzed the results collected after 4 h (t-PET) and after 2 h (mini-PET) for glucose and creatinine and did not find a correlation between the results.…”

Section: Discussionmentioning

confidence: 99%

Comparison of three PET methods to assess peritoneal membrane transport

Romani

Waniewski

Kruger

et al. 2019

Braz J Med Biol Res

View full text Add to dashboard Cite

The peritoneal equilibration test (PET) is the most widespread method for assessing water and solute transport across the peritoneal membrane. This study compared three methods: traditional PET (t-PET), mini-PET, and modified PET (mod-PET). Non-diabetic adults (n=21) who had been on peritoneal dialysis (PD) for at least three months underwent t-PET (glucose 2.5%-4 h), mini-PET (glucose 3.86%-1 h), and mod-PET (glucose 3.86%-4 h) to determine dialysate-to-plasma concentration ratio (D/P) for creatinine and dialysate-to-baseline dialysate concentration ratio (D/D0) for glucose. Agreement between methods regarding D/P creatinine and D/D0 glucose was assessed using analysis of variance (ANOVA), Pearson's correlation coefficient, and Bland-Altman analysis. D/P creatinine differed between t-PET and mini-PET (P<0.001) and between mod-PET and mini-PET (P<0.01) but not between t-PET and mod-PET (P=0.746). The correlation of D/P creatinine with t-PET vs mod-PET was significant (r=0.387, P=0.009) but not that of t-PET vs mini-PET (r=0.088, P=0.241). Estimated bias was −0.029 (P=0.201) between t-PET and mod-PET, and 0.206 (P<0.001) between t-PET and mini-PET. D/D0 glucose differed between t-PET and mod-PET (P=0.003) and between mod-PET and mini-PET (P=0.002) but not between t-PET and mini-PET (P=0.885). The correlations of D/D0 glucose in t-PET vs mod-PET (r=−0.017, P=0.421) or t-PET vs mini-PET (r=0.152, P=0.609) were not significant. Estimated bias was 0.122 (P=0.026) between t-PET and mod-PET, and 0.122 (P=0.026) between t-PET and mini-PET. The significant correlation of D/P creatinine between t-PET and mod-PET suggested that the latter is a good alternative to t-PET. There was no such correlation between t-PET and mini-PET.

show abstract

“…In conclusion, dwell time of 2 hours provides reliable results and time-saving procedure for the health care personnel and it could be used for the clinical assessment of the patients [5,[10][11][12]. In contrast, a study in children found no correlation between 2-hour and 4-hour dwell times and the authors reported that short testing procedure would not be reliable in pediatric population for the assessment of peritoneal membrane functions [13].…”

Section: Discussionmentioning

confidence: 99%

The Fast Peritoneal Equilibration Test First and Second Hour Results

et al. 2015

View full text Add to dashboard Cite

Introduction. The Peritoneal Equilibration Test (PET) is employed to assess peritoneal membrane transport function. The purpose of the test is to determine the optimal peritoneal dialysis regimen. The performance of the test, which is conducted over 4 hours, is time consuming both for the nurses and the patient. There have been studies to validate an approved short version of the original PET protocol, and all have yielded different results. We evaluated the concordance between the 1-hour, 2-hour and 4-hour (classical) test results of the fast PET. Methods. The study included 32 patients (20 males and 12 females). The patients underwent the 4-hour fast PET test, and the dialysate-to-plasma ratio of creatinine concentration (D/Pcrea) was determined. The standard deviation was added to or subtracted from the mean D/Pcrea ratios at hours 1, 2, and 4 to determine transport groups. Results. The mean age of the patients was 51.4±16.7 years. Mean D/Pcrea ratios at hours 1, 2, and 4 were 0.41±0.07, 0.54±0.10, and 0.69+0.12, respectively. There was a strong correlation between the 4-hour D/Pcrea ratio and 1-hour (r=0.756, p<0.001) and 2-hour (r=0.867, p<0.001) D/Pcrea ratios. Seventeen patients (53%) were in the same transport group at hours 1, 2, and 4. Eighteen patients (56%) at 1 hour and 24 patients (75%) at 2 hours fell into the same transport group at 4 hours. The patients that fell into different transport groups at different time points showed a shift to a lower or higher transport group. Conclusions. Two-hour fast PET gives promising results for clinical assessment purposes.

show abstract

Short PET in pediatric peritoneal dialysis

Cited by 6 publications

References 8 publications

The short peritoneal equilibration test in pediatric peritoneal dialysis

The short peritoneal equilibration test in pediatric peritoneal dialysis

Comparison of three PET methods to assess peritoneal membrane transport

The Fast Peritoneal Equilibration Test First and Second Hour Results

Contact Info

Product

Resources

About