Short course of systemic corticosteroids in sinonasal polyposis: A double‐blind, randomized, placebo‐controlled trial with evaluation of outcome measures

Hissaria, Pravin; Smith, William; Wormald, Peter John; Taylor, James; Vadas, Mathew A.; Gillis, David; Kette, Frank

doi:10.1111/j.1749-4486.2007.01593.x

Cited by 73 publications

(113 citation statements)

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“…Lower frequency of allergic rhinitis and similar polyp size after medication are postulated as the reasons. Earlier studies reported that systemic steroid improved SNOT-20 score correlated with the decrease in polyp size [6,12]. In the present study, the SNOT-20 score improved in the response group, but not in the nonresponse group, corresponding with previous studies.…”

Section: Discussionsupporting

confidence: 92%

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Treatment outcomes and predictors for systemic steroids in nasal polyposis

Won

Jang²,

Min

et al. 2012

Acta Oto-Laryngologica

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In all, 62% of the patients were responders, i.e. had a decreased polyp size >25% after treatment. SNOT-20 score tended to decrease for all patients but significantly only for the responder group (p < 0.01). Eighteen of the responders had a medical history of allergic rhinitis, but only five of the nonresponders did (p = 0.026, Odds ratio = 4.26). Responder group polyps showed significantly less immunoreactivity of glucocorticoid receptor β than polyps from the nonresponder group.

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Section: Discussionsupporting

confidence: 92%

“…Generally, subjective symptom improvement has been used for outcome evaluation in nasal polyposis and chronic rhinosinusitis. Objective criteria used were change in polyp size, olfactory function test, and Lund-Mackay score based on CT/MRI [6][7][8]. Among these, change in polyp size is easy to observe via nasal endoscope.…”

Section: Discussionmentioning

confidence: 99%

Treatment outcomes and predictors for systemic steroids in nasal polyposis

Won

Jang²,

Min

et al. 2012

Acta Oto-Laryngologica

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“…Hissaria et al [36], in a randomized trial, demonstrated that prednisone improved sinonasal symptoms and reduced polyp size in 2 weeks. Hissaria et al [36], in a randomized trial, demonstrated that prednisone improved sinonasal symptoms and reduced polyp size in 2 weeks.…”

Section: Systemic Glucocorticordsmentioning

confidence: 99%

An update on the classifications, diagnosis, and treatment of rhinosinusitis

Chan

Kühn

2009

Current Opinion in Otolaryngology & Head and Neck Surgery

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“…Hissaria and colleagues (2006) compared 50 mg prednisolone daily for 14 days with placebo. A significant difference was found in nasal symptoms and endoscopic findings.…”

Section: Medical Treatmentmentioning

confidence: 99%

A review of nasal polyposis

Newton

Ah‐See²

2008

TCRM

153

131

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Nasal polyps are common, affecting up to four percent of the population. Their etiology remains unclear, but they are known to have associations with allergy, asthma, infection, cystic fi brosis, and aspirin sensitivity. They present with nasal obstruction, anosmia, rhinorrhoea, post nasal drip, and less commonly facial pain. Clinical examination reveals single or multiple grey polypoid masses in the nasal cavity. Computerized tomography allows evaluation of the extent of the disease and is essential if surgical treatment is to be considered. Management of polyposis involves a combination of medical therapy and surgery. There is good evidence for the use of corticosteroids (systemic and topical) both as primary treatment and as postoperative prophylaxis against recurrence. Surgical treatment has been refi ned signifi cantly over the past twenty years with the advent of endoscopic sinus surgery and, in general, is reserved for cases refractory to medical treatment. Recurrence of the polyposis is common with severe disease recurring in up to ten percent of patients.

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Short course of systemic corticosteroids in sinonasal polyposis: A double‐blind, randomized, placebo‐controlled trial with evaluation of outcome measures

Cited by 73 publications

References 0 publications

Treatment outcomes and predictors for systemic steroids in nasal polyposis

Treatment outcomes and predictors for systemic steroids in nasal polyposis

An update on the classifications, diagnosis, and treatment of rhinosinusitis

A review of nasal polyposis

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