Shope Papilloma Virus: Reversion of Adaptation to Domestic Rabbit by Passage through Cottontail

Selbie, F. R.; Robinson, R. H. M.; Shope, R. E.

doi:10.1038/bjc.1948.41

Cited by 9 publications

(2 citation statements)

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“…The decrease in relative arginase activity in tumors induced by the recoverable virus line, as compared to the wild-type (Table I), is of interest since their growth rate is slower than that of papillomas induced with wild-type virus (5). This is consistent with the finding that the amount of available arginine in the infected cells is a determining factor in controlling the synthesis of an argininerich histone associated with growth of the virus-infected cells (2, 8).…”

Section: Discussionmentioning

confidence: 99%

Change in the Structure of Shope Papilloma Virus-Induced Arginase Associated With Mutation of the Virus

Rogers

1971

The Journal of Experimental Medicine

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The change in the state of the virus-induced enzyme associated with a mutation in the virus provides additional evidence that the enzyme is synthesized from virus rather than rabbit genetic information. This change in structure results in differences in stability of polymerization, degree of optical rotary dispersion (ORD) specific rotation, change in elution characteristics from carboxymethyl cellulose, and a reduction in specific activity of the arginase. Liver arginase differs markedly in ORD characteristics from the virus-induced enzyme. In contrast to the virus-induced enzyme, it showed no negative Cotton effect at 233 nm until it was activated with manganese. Manganese had no influence on the ORD spectrum of virus-induced arginase. In addition, liver arginase is denatured by 4 M urea, while the virus-induced enzyme requires 10 M urea for denaturation.

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Section: Discussionmentioning

confidence: 99%

Change in the Structure of Shope Papilloma Virus-Induced Arginase Associated With Mutation of the Virus

Rogers

1971

The Journal of Experimental Medicine

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“…Rabbit papilloma virus has occasionally been maintained by repeated passages in the domestic rabbit (Shope, 1935). One such domestic rabbitadapted strain lost its adaptation in a single passage in cottontail hare (Selbie et al, 1948). The conditions did exist for selection in the cottontail of a better growing variant, but the occurrence of a pair of host-controlled forms cannot be excluded.…”

Section: Host-induced Modifications In Viruses Other Thxn Phacementioning

confidence: 99%