The Role of Viruses in the Production of Cancer

Oberling, C; Guérin, M

doi:10.1016/s0065-230x(08)60499-6

Cited by 103 publications

(45 citation statements)

References 204 publications

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“…Furthermore, shortterm experiments carried out with animals (Tripoli and Haam, 1932; Irwin, 1932) seemed to support the belief that thorotrast was harmless under the conditions and in the doses then used. Oberling and Guerin (1933) injected 1 c.c. of thorotrast intraperitoneally, twice a week for 5 weeks, into rats grafted with Jensen sarcoma, and found that in a number of animals the tumours regressed.…”

mentioning

confidence: 99%

The Late Effects of Thorotrast Administration. A Review and an Experimental study

Guimarães¹,

Lamerton²,

Christensen³

1955

Br J Cancer

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mentioning

confidence: 99%

The Late Effects of Thorotrast Administration. A Review and an Experimental study

Guimarães¹,

Lamerton²,

Christensen³

1955

Br J Cancer

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“…Even this drastic technique sometimes yielded negative results (e.g. Oberling et al, 1936;Woglom, 1938). On the other hand, adenomata of the renal cortex have been repeatedly induced by other agents, e.g.…”

Section: Significance Of Experimental Resultsmentioning

confidence: 99%

Tumours of Many Sites Induced by Injection of Chemical Carcinogens into Newborn Mice, A Sensitive Test for Carcinogenesis: The Implications for Certain Immunological Theories

Roe¹,

Rowson²,

Salaman³

1961

Br J Cancer

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RIeceived f'o publ)Ii(ation mJun 27'. 19(61 PIIETRA, SPEN?CER AND) SHUBIK (1959) reported the induction of maligilailt lymplJ)oma (lymphocytic leukaemia) and lung adenomas in Swiss mice injected sulbcutaneollsly when new-born (less than 24-hour old), with 30 jig. 9,10-dimethyl-1,2-henzanthracene (DMBA) suspended in 1 per cent aqueous gelatine. Later, Stich (1960) obtainedl a similar result using a 60 ,lg. dose of DMBA. W11e were interested in the report of Pietra et al. (1959) for two reasonis. Firstly we were anxious to discover whether cell-free filtrates prepared from malignant lymnphoma induced by the injection of a carcinogen could themselves be passed to other mice bv mea,ns of cell-fiee filtrates (e.g. G(ross, 1957), and this method of chemical induction of lymphoma seenmed ver-y suitable. Secondly, the method described bv Pietra et, al. (1959) offered the possibility of a highly sensitive test for carcinogenic activity. In the latter coninection it was important to find out whether other strains of mice would respond in the same way as the Swiss nlice used by Pietra et al., and also whether leukaemiia and lung tumours could te induced; bv the injection of other carcinogens, I)oth strong and weak, into newb)orn mice.At the time that the present paper was ready for submissioni a second paper by Pietra and his colleagues (Pietra, Rappaport and Shubik, 1961) was publishedl. The latter extende(d tlheir earlier findings in four directions: firstly thev confirmed their original observation with DMBA. secondly they tested 4 othercarcinogens, 3,4-benzopyrene, 20-nvmthylcholanthrene, 1,2:5, 6-dibenzanthraceiie, aI)d urethane by the same method; thirdly they compared the sulbcutanieouis and intraperitoneal routes of administration for each of the 5 carcinogens : and fourthly thev reported the induction of tumours at sites other than the lung and the lymphatic system. Even more recently Fiore-Donati et al. (1961) have recorded similar findings in an experiment in which new-born mice were injected with urethaie and Kelly and O'Gara (1961) have obtained similar results w-ith 20-methylcholanthrene and 1,2:5,6-dibenzanthracene.Work reported in the present paper confirms and extends the studies of Pietra and his colleagues. Two inbred strains of mice were used, and their response to DMBA compared. Induction of tumours of many sites, including those mentioned by Pietra et al. (1961), is described.

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“…Caviae show no sensitivity to painting with benzo(a)pyrene. It is indeed known that the epidermis of this species fails to react to locally-applied carcinogenic substances (benzo(a)-pyrene: Oberling et al, 1936;methylcholanthrene: Silberstein and Silberstein, 1947;DMBA: Berenblum, 1949) and that spontaneous cervico-vaginal carcinoma is unknown in it (Tamaschke, 1955).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, this lack of neoplastic response of the cervico-vaginal epithelium to benzo(a)pyrene corresponds to that of the epidermis (Glucksmann, 1945), although it would not be correct to state that the epidermis of the rat is completely resistant to local treatment with benzo(a)pyrene (Oberling and Guerin, 1947). The rat epidermis is much more sensitive to DMBA (Berenblum, 1949), which may explain why Glucksmann (1956) was able to induce carcinoma of the vulva with this carcinogen.…”

Section: Discussionmentioning

confidence: 99%

Species and Strain Differences in the Susceptibility of the Cervico-Vaginal Squamous Epithelium to 3,4-Benzo(a)pyrene

Thiery¹,

Vangijsegem²

1965

Br J Cancer

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The Role of Viruses in the Production of Cancer

Cited by 103 publications

References 204 publications

The Late Effects of Thorotrast Administration. A Review and an Experimental study

The Late Effects of Thorotrast Administration. A Review and an Experimental study

Tumours of Many Sites Induced by Injection of Chemical Carcinogens into Newborn Mice, A Sensitive Test for Carcinogenesis: The Implications for Certain Immunological Theories

Species and Strain Differences in the Susceptibility of the Cervico-Vaginal Squamous Epithelium to 3,4-Benzo(a)pyrene

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