Shimian granules improve sleep, mood and performance of shift nurses in association changes in melatonin and cytokine biomarkers: a randomized, double-blind, placebo-controlled pilot study

Zhang, Li; Zhang, Ruihuan; Shen, Yan; Qiao, Shuzhen; Hui, Zhenliang

doi:10.1080/07420528.2020.1730880

Cited by 7 publications

(37 citation statements)

References 67 publications

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“…In contrast to all these results, a recent study published by Zhang et al [49] found that salivary TNFα and IL-6 levels were directly correlated with insomnia severity in nurses who worked shifts and the administration of Shimian granules (a traditional Chinese herbal medicine) improve sleep and decreased the level of these inflammatory markers in saliva suggesting that similar to other intervention mentioned before [43], they could be a possible marker to monitor the effects of interventions to improve sleep quality.…”

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 82%

“…In four of them, no significant changes were detected between the study groups in the levels of IL-1β related to sleep [41,43,48,51]. There was a reduction in this cytokine in only one of the seven articles [49], coinciding with significantly lower insomnia, anxiety, and depression scores in the intervention group. In two others, there was an increase in IL-1β in saliva.…”

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 86%

“…IL-6 was measured in 9 of the 13 articles analyzed [41,43,[45][46][47][48][49][50]52]. According to the study published by Li Zhang et al [49] on nurses who did shift work, IL-6 levels were correlated with the ISI (Insomnia Severity Index). The results published by Nejat Nizam et al [41] show that TNFα and IL-6 levels were correlated to ISI scores, and salivary concentrations of IL-6 and IL-33 were similar in the two groups of OSA (Obstructive Sleep Apnea Syndrome) and higher than in the control group.…”

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

“…Seven of the reviewed articles [41,43,44,[47][48][49]51] analyze the relationship between IL-1β levels in saliva and sleep. In four of them, no significant changes were detected between the study groups in the levels of IL-1β related to sleep [41,43,48,51].…”

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

“…Evidence regarding the levels of TNFα in saliva related to sleep is reported in three articles, with different results in terms of the associations with sleep parameters [45,48,49]. In one of them, the salivary TNFα levels increase, in another they decrease, and in the third they are unchanged.…”

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

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Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review

et al. 2021

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Poor sleep quality and sleep disorders are the most common problems in people, affecting health-related quality of life. Various studies show an association between sleep disorders and altered levels of stress hormones and inflammatory cytokines measured in saliva. The main objective of this article is to provide an analysis of the current evidence related to changes in inflammatory markers in the saliva and their associations with sleep quality measurement (both objective and subjective methods) in healthy subjects and in sleep-related disorders. To that end, a scoping review was carried out, following the PRISMA criteria in the bibliographic search in several databases: PubMed, EBSCO, and SCOPUS. Eleven of the articles are from the adult population and two from the child-youth population. They mainly measure the relationship between sleep and interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNFα) alpha, as well as other inflammatory markers such as myeloperoxidase (MPO) and prostaglandin-endoperoxide synthase 2. An analysis shows the relationship between these salivary biomarkers and sleep quality, especially in the case of IL-6 in both healthy subjects and several pathologies associated with sleep-disorders. The results for TNFα and IL-1β measurements are still inconclusive and the difference with IL-6 was assessed. Two studies reported interventions that result in sleep improvement and are accompanied by the normalization of inflammatory changes detected in the saliva. As it is an easy-to-apply and non-invasive method, the measurement of salivary cytokines can be very useful in chronobiology studies. Further studies are required to determine the sensitivity of salivary inflammatory markers in monitoring biological rhythms and acting as biomarkers in the detection of sleep disorders and sleep interventions.

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Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 82%

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 86%

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

Section: Salivary Inflammatory Markers Measured In the Analyzed Studiesmentioning

confidence: 99%

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Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review

et al. 2021

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Interventions to improve the sleep of nurses: A systematic review

Zhang,

Murphy,

Lammers‐van der Holst

et al. 2023

Research in Nursing & Health

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Nurses are at a high risk for short sleep duration and poor sleep quality due to irregular work schedules and high occupational stress. Considering the effect of nurses' sleep on the safety and health of themselves and their patients, it is important to promote healthy sleep for nurses. We sought to synthesize the published experimental and quasi‐experimental studies that address interventions to improve sleep in nurses. A systematic search was conducted for studies published in English up until May 15, 2023, using the databases PubMed, CINAHL, Academic Search Ultimate, and PsycINFO. In total, 38 articles were included, covering 22 experimental and 16 quasi‐experimental studies with sample sizes ranging from 9 to 207. Studies were assessed using the Cochrane Risk of Bias tool and considered as low to medium quality. Thirty‐six of the 38 studies reported positive findings for at least one sleep outcome. Intervention types included aroma therapy, dietary supplements, cognitive behavioral therapy, light therapy, mind‐body therapy, sleep education, exercise, napping, shift schedule modification, and multicomponent intervention, all of which showed moderate effectiveness in promoting sleep outcomes of nurses. Comparing and contrasting studies on specific interventions for improving sleep in nurses is sparse and often equivocal. With the variations of research methodology and outcome measures, it is difficult to make a conclusion about each intervention's effectiveness on specific sleep outcomes. Additional high‐quality research, including randomized controlled trials, is needed to evaluate strategies for improving sleep in this unique, safety‐sensitive occupational group.

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Network Pharmacology-Based and Molecular Docking-Based Analysis of Suanzaoren Decoction for the Treatment of Parkinson’s Disease with Sleep Disorder

Liu

Zhang

et al. 2021

BioMed Research International

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This study is aimed at exploring the possible mechanism of action of the Suanzaoren decoction (SZRD) in the treatment of Parkinson’s disease with sleep disorder (PDSD) based on network pharmacology and molecular docking. Traditional Chinese Medicine Systems Pharmacology (TCMSP) was used to screen the bioactive components and targets of SZRD, and their targets were standardized using the UniProt platform. The disease targets of “Parkinson’s disease (PD)” and “Sleep disorder (SD)” were collected by OMIM, GeneCards, and DisGeNET databases. Thereafter, the protein-protein interaction (PPI) network was constructed using the STRING platform and visualized by Cytoscape (3.7.2) software. Then, the DAVID platform was used to analyze the Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. Cytoscape (3.7.2) software was also used to construct the network of the “herb-component-target-pathway.” The core active ingredients and core action targets of the drug were verified by molecular docking using AutoDock software. A total of 135 Chinese herbal components and 41 corresponding targets were predicted for the treatment of PDSD using SZRD. Fifteen important signaling pathways were screened, such as the cancer pathway, TNF signaling pathway, PI3K-AKT signaling pathway, HIF-1 signaling pathway, and Toll-like receptor signaling pathway. The results of molecular docking showed that the main active compounds could bind to the representative targets and exhibit good affinity. This study revealed that SZRD has the characteristics and advantages of “multicomponent, multitarget, and multipathway” in the treatment of PDSD; among these, the combination of the main active components of quercetin and kaempferol with the key targets of AKT1, IL6, MAPK1, TP53, and VEGFA may be one of the important mechanisms. This study provides a theoretical basis for further study of the material basis and molecular mechanism of SZRD in the treatment of PDSD.

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Shimian granules improve sleep, mood and performance of shift nurses in association changes in melatonin and cytokine biomarkers: a randomized, double-blind, placebo-controlled pilot study

Cited by 7 publications

References 67 publications

Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review

Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review

Interventions to improve the sleep of nurses: A systematic review

Network Pharmacology-Based and Molecular Docking-Based Analysis of Suanzaoren Decoction for the Treatment of Parkinson’s Disease with Sleep Disorder

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