Shift of motor activation areas during recovery from hemiparesis after cerebral infarction: A longitudinal study with near-infrared spectroscopy

Takeda, Kotaro; Gomi, Yukihiro; Imai, Itsuki; Shimoda, Nobuaki; Hiwatari, Masao; Kato, Harubumi

doi:10.1016/j.neures.2007.06.1466

Cited by 72 publications

(78 citation statements)

References 42 publications

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“…During right hand grasping without mirror viewing (condition A), the LI showed a contralateral SMC predominant activation pattern. This activation pattern was the same as that observed in previous NIRS studies 11,12,16) . However, the same subjects exhibited LI that was close to zero during left hand grasping without mirror viewing (condition C).…”

Section: Discussionsupporting

confidence: 88%

“…The standard deviation (SD) was calculated against 5-s rest periods just before the target grasping blocks and then each set of data of ∆[Oxy-Hb] was transformed into a z score through division by the SD of each To determine which cerebral hemisphere was activated predominantly in the experimental paradigm, we used a laterality index (LI) calculated as LI = (ML-MR)/(ML+MR), where ML and MR were the activation areas during the grasping task in the ROI of the left and right SMCs, respectively. The LI ranges from -1 (exclusively right hemispheric predominance) to +1 (exclusively left hemispheric predominance) 16) . The extent of activation in each hemisphere and the LIs of all the experimental conditions were compared with one-way ANOVA.…”

Section: Methodsmentioning

confidence: 99%

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Sensorimotor Cortex Activation during Mirror Therapy in Healthy Right-Handed Subjects: A Study with Near-Infrared Spectroscopy

et al. 2008

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Abstract.Clinical studies have shown that functional motor recovery after stroke may be facilitated by mirror therapy (MT). However, its underlying mechanism is uncertain. In this study, we examined brain activation during unilateral hand movement in 5 right-handed healthy subjects (1 male and 4 females) with or without viewing a mirror reflection of the moving hand (MT). We measured the changes in the concentration of oxygenated hemoglobin in the primary sensorimotor cortex (SMC) using near-infrared spectroscopy. We calculated the laterality index (LI) using the extent of activation in the right and left SMCs. The LIs (± standard error of mean) during right hand grasping without and with MT were 0.17 ± 0.11 (left SMC predominance) and -0.42 ± 0.24 (right SMC predominance), respectively (p < 0.05). However, there was no significant difference in LIs during left hand grasping without and with MT (0.02 ± 0.05 and 0.08 ± 0.05, respectively). The findings suggest that MT is more effective when it is used for dominant right hand movement, and this phenomenon may be the related to the different manipulability between the dominant and non-dominant hands.

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Section: Discussionsupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Sensorimotor Cortex Activation during Mirror Therapy in Healthy Right-Handed Subjects: A Study with Near-Infrared Spectroscopy

et al. 2008

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“…We set the fNIRS probe to cover the sensorimotor cortex by referring to previous studies [23][24][25]. We used 2 sets of 3 × 5 multichannel probe holders, consisting of 8 illuminating and 7 detecting probes arranged alternately at an inter-probe distance of 3 cm, resulting in 22 channels (CHs) per set.…”

Section: Fnirs Probe Placementmentioning

confidence: 99%

Reduction in Cortical Activation in the Sensorimotor Cortex during Motor Skill Learning of a Pursuit Rotor Task: A Functional Near-Infrared Spectroscopy Study

Hirano

Seki²,

Huang³

et al. 2014

Int J Phys Med Rehabil

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To investigate the cerebral mechanisms underlying learning of motor skills, we assessed serial changes of brain activation patterns during a pursuit rotor (PR) task in 12 right-handed healthy subjects using functional near-infrared spectroscopy (fNIRS). The subjects performed the task with their right hand for 15-s, alternated with a 30-s rest period, for 18 repetitions (cycles 1 to 18). Gains in motor skill were evaluated by recording the time for which the stylus remained on the target. Performance improved with repetition of the task. Task-related increases of oxygenated hemoglobin (oxy-Hb) were observed around the predicted location of the sensorimotor cortices on both hemispheres. The increased oxy-Hb levels appeared to reduce with repetition of the task in the channels covering the left sensorimotor area. Furthermore, there was a significant correlation between PR task performance gain and the oxy-Hb signal in the left and right sensorimotor areas. Our results suggest that cortical activation in the sensorimotor cortex reflects changes in a number of factors including sensory feedback processing, correct motor commands, and perceptual or cognitive function during learning of a PR task. Therefore, changes in contralateral sensorimotor cortical activation may serve as a motor sequence learning biomarker for rehabilitation purposes or the prediction of recovery.

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“…The contralesional shift of activation may return to ipsilesional S1M1 activation with functional gains (Feydy et al, 2002;Takeda et al, 2007), but worse outcome may correlate with a shift in the balance of activation toward the contralesional S1M1 (Calautti et al, 2001;Feydy et al, 2002;Zemke et al, 2003). Thus, the patterns of cerebral activation evoked by active hand movement show impaired organization and reorganization of brain sensorimotor network, and best recovery may depend on how much original motor system is reusable.…”

Section: Activation Of Sensorimotor Network By Active Motor Taskmentioning

confidence: 99%

Activation of Brain Sensorimotor Network by Somatosensory Input in Patients with Hemiparetic Stroke: A Functional MRI Study

Kato¹,

Izumiyama²

2013

Novel Frontiers of Advanced Neuroimaging

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Shift of motor activation areas during recovery from hemiparesis after cerebral infarction: A longitudinal study with near-infrared spectroscopy

Cited by 72 publications

References 42 publications

Sensorimotor Cortex Activation during Mirror Therapy in Healthy Right-Handed Subjects: A Study with Near-Infrared Spectroscopy

Sensorimotor Cortex Activation during Mirror Therapy in Healthy Right-Handed Subjects: A Study with Near-Infrared Spectroscopy

Reduction in Cortical Activation in the Sensorimotor Cortex during Motor Skill Learning of a Pursuit Rotor Task: A Functional Near-Infrared Spectroscopy Study

Activation of Brain Sensorimotor Network by Somatosensory Input in Patients with Hemiparetic Stroke: A Functional MRI Study

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