2018
DOI: 10.1111/jcpe.12862
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Shift in the subgingival microbiome following scaling and root planing in generalized aggressive periodontitis

Abstract: Scaling and root planing decreased periodontal pathogens in the subgingival microbiota of patients with GAgP. However, the shift in the microbiota composition was characterized by the expansion of pathogen-related components and the contraction of non-pathogen-related components 6 weeks after SRP. Clinicaltrials.gov #NCT03090282.

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Cited by 46 publications
(97 citation statements)
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“…This diversity difference remained in the young animals even after ligation, while the profiles in the adolescent animals began to approach 60% of the OTUs by 1 month postligation, similar to the maintenance of 60% to 70% of the OTUs during disease in the older animals. This type of finding has been reported for human periodontitis with lower diversity in disease samples, albeit findings vary (62)(63)(64)(65). It has also been reported that while members of the oral microbiome may differ across individuals, the functional genomics of the bacterial population are more similar in health, with substantial changes in the gene expression profiles of commensals with disease (9,20,66).…”
Section: Discussionsupporting
confidence: 60%
See 1 more Smart Citation
“…This diversity difference remained in the young animals even after ligation, while the profiles in the adolescent animals began to approach 60% of the OTUs by 1 month postligation, similar to the maintenance of 60% to 70% of the OTUs during disease in the older animals. This type of finding has been reported for human periodontitis with lower diversity in disease samples, albeit findings vary (62)(63)(64)(65). It has also been reported that while members of the oral microbiome may differ across individuals, the functional genomics of the bacterial population are more similar in health, with substantial changes in the gene expression profiles of commensals with disease (9,20,66).…”
Section: Discussionsupporting
confidence: 60%
“…Finally, it is clear that standard nonsurgical therapy of scaling and root planing lowers the microbial burden in periodontitis and decreases inflammation as an approach to controlling the disease (44,62,64). However, while the majority of the population responds well to this treatment, a portion of the population continues to demonstrate disease, with little predictive understanding of who constitutes this "nonresponding" group (70)(71)(72)(73).…”
Section: Discussionmentioning
confidence: 99%
“…Calculation of the Shannon and Simpson diversity indices did not display significant differences over time in the present study, indicating an overall resilience of the salivary microbiome to external pressures, one such being periodontal treatment. Earlier diversity analyses of the subgingival [ 24 ] or salivary [ 28 ] microbiome of AgP did not reveal significant differences post‐treatment either, in line with the present findings. On the contrary, treatment of chronic periodontitis is shown to cause significant reduction in the diversity of the salivary microbiome, [ 28 ] but not necessarily significant differences in the abundance of the predominant bacterial species.…”
Section: Discussionsupporting
confidence: 91%
“…[ 21 ] Microbial shifts following treatment have also been studied, but with less consistent findings. [ 8,22–24 ] Divergences in the microbial profiles according to the treatment outcome (successful or not) are also not well characterized. [ 25 ]…”
Section: Introductionmentioning
confidence: 99%
“…The characteristics of the subgingival microbiome in patients with periodontitis and its shift after clinical intervention have been investigated. It was demonstrated that patients with periodontitis harboured a more pathogenic microbial community than healthy individuals (Abusleme et al, ), and the proportion of periodontitis‐associated taxa decreased and the proportion of health‐associated taxa increased after periodontal treatment (Liu et al, ; Shi et al, ). Then, the bacteria recolonized in periodontal pockets.…”
Section: Introductionmentioning
confidence: 99%