Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation

Wang, Hong-Jaan; Lu, Chung‐Kuang; Chen, Wei-Ching; Chen, An-Chi; Ueng, Yune-Fang

doi:10.1016/j.jfda.2018.10.005

Cited by 8 publications

(21 citation statements)

References 39 publications

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“…Histological features were also similar to those given by the group given nifedipine as a comparison. Nifedipine has been demonstrated to be useful and generally well tolerated for the treatment of stable, variable, and unstable angina, mild to severe hypertension, and Raynaud's phenomenon (Wang et al, 2019). It is an antagonist of calcium influx through slow cell membrane channels.…”

Section: Discussionmentioning

confidence: 99%

“…Five treatments were given to the rats that were identified as being pregnant: (a) normal pregnant rats (control); (b) hypertensive rats; (c) hypertensive rats + 100 mg/kg BW R. tomentosa (RHO); (d) hypertensive rats + 200 mg/kg BW R. tomentosa (RHO); and (e) hypertensive rats + 400 mg/kg BW R. tomentosa (RHO); (f) hypertensive rats + 3 mg/kg BW nifedipine (Wang et al, 2019). Under ketamine anesthesia, pregnant rats were removed on their 20 th day of gestation.…”

Section: Methodsmentioning

confidence: 99%

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Effect of Rhodomyrtus tomentosa Hassk. on HIF1α and VEGF expressions on hypertension placental

Situmorang¹,

Ilyas²,

Siahaan³

et al. 2022

J Pharm Pharmacogn Res

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Context: HIF1α and VEGF are proteins marker oxidative stress and a decrease in placental growth factor (PlGF). Decreasing of HIF1α and VEGF in rats displayed poor trophoblast differentiation, placental abnormalities, and fetal mortality. Rhodomyrtus tomentosa is a flowering plant in the Myrtaceae family that has the potential to be a source of health-promoting chemicals. Aims: To analyze HIF1α and VEGF in serum and hypertension placental tissue after giving Rhodomyrtus tomentosa (RHO) leaves extract. Methods: Six treatments were given to the rats that were identified as being pregnant and pregnant rats with hypertension were given RHO with three doses: (a) normal pregnant rats (control); (b) hypertensive rats; (c) hypertensive rats + 100 mg/kg BW of RHO; (d) hypertensive rats +200 mg/kg BW of RHO; and (e) hypertensive rats + 400 mg/kg BW of RHO and (f) hypertensive rats + nifedipine. Under ketamine anesthesia, pregnant rats were removed on their 20th day of gestation. Immunohistochemistry and ELISA were used to assess HIF1α and VEGF protein expression. Results: There was a significant difference (p<0.01) in the expression of HIF1α and VEGF in the labyrinthine zone and yolk sac of the rat placenta between the normal (C-) and hypertensive (C+) groups. HIF1α and VEGF expression decreased when RHO was administered at doses ranging from 100 to 400 mg/kg BW. However, there was no significant change (p>0.05) in VEGF expression in the basal zone of the rat placenta across all groups. Conclusions: Rhodomyrtus tomentosa leaves extract decreases HIF1α and VEGF expressions in serum and repairs the tissue of the placenta's labyrinth, basal, and yolk sacs.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effect of Rhodomyrtus tomentosa Hassk. on HIF1α and VEGF expressions on hypertension placental

Situmorang¹,

Ilyas²,

Siahaan³

et al. 2022

J Pharm Pharmacogn Res

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“…In Taiwan’s TCM prescriptions for patients with ischemic heart disease, 16% of prescriptions contained SMS, which was among the top three frequently used formulas [ 78 ]. A 1-h pretreatment of rats with SMS decreased nifedipine clearance, accompanied by decreased hepatic oxidation activity, which was primarily catalyzed by CYP3A [ 133 ]. However, 3-week repeated oral treatments with SMS suppressed rat intestinal, but not hepatic, nifedipine oxidation activity [ 134 ].…”

Section: Potential Hdis Between Tcm Formulas and Prescribed Cvd Drugsmentioning

confidence: 99%

“…The results of the in vitro inhibition study indicated the presence of time-dependent CYP3A inhibitor(s) in SMS. Among the SMS ingredients, the Schisandra lignan, schisandrin B was reported to be a PXR activator [ 136 ] but also potently inhibited rat liver microsomal CYP3A activity [ 133 ]. Although drug interactions occur in vivo , reversible and irreversible inhibition, as well as induction, may work in a complex manner.…”

Section: Potential Hdis Between Tcm Formulas and Prescribed Cvd Drugsmentioning

confidence: 99%

“…Deoxyschizandrin and schisantherin A inhibit UGT1A3 with IC 50 values equal to 10.8 and 12.5 μM in a recombinant UGT system, respectively [ 139 ]. However, acute (1 h) and repeated (daily for 3 weeks) treatments with SMS powdered decoction did not cause significant changes in rat hepatic and intestinal UGT activities [ 133 , 134 ]. To reveal the impact of UGT inhibition by these ingredients of SMS component herbs, further studies on the PK changes in glucuronide metabolites are crucial.…”

Section: Potential Hdis Between Tcm Formulas and Prescribed Cvd Drugsmentioning

confidence: 99%

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Metabolism-involved drug interactions with traditional Chinese medicines in cardiovascular diseases

Liang¹,

Hsu²,

Chang³

et al. 2022

Journal of Food and Drug Analysis

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Herbal medicines have been widely used for the past millennia. Traditional Chinese medicine (TCM) is a major modality in Chinese medical care and has garnered global attention owing to its pharmacological effects and multi-targeted actions. The increased incidence of sequential or concurrent use of herbs and drugs in patients forces us to consider herb–drug interactions (HDIs) in this modern era. One of the main causes of HDIs is modulation of drug metabolism, in which cytochrome P450 (CYP), UDP-glucuronosyltransferase (UGT), and transporters play primary roles. In this review, we focus on in vivo studies of HDIs, particularly in the treatment of cardiovascular disease (CVD), which is currently the leading cause of disease-related mortality worldwide. A total of 55 HDIs are summarized, and their potential underlying mechanisms are examined. The pharmacokinetic (PK) and pharmacodynamic (PD) effects of three single herbs (Danshen, Ginseng, and Ginkgo) and four compound prescriptions (Shenmai injection, Shengmai-San, Shu-Jing-Hwo-Shiee-Tang, and Wu-Chu-Yu-Tang) are discussed. Due to the complex compositions and PK/PD profiles of TCMs, the determinants of significant HDIs have been listed to further define the pros and cons of HDIs in medical care.

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Pharmacokinetics and Bioequivalence of 2 Nifedipine Controlled‐Release Tablets: A Randomized, Single‐Dose, 2‐Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions

Xin

Chen²,

Chen³

et al. 2023

Clinical Pharm in Drug Dev

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The aim of this study was to evaluate the bioequivalence of generic nifedipine controlled‐release tablet compared to branded product under fasting and fed conditions. A randomized, single‐dose, 2‐period, crossover study with a 7‐day washout period was performed in 84 healthy Chinese volunteers (fasting cohort, n = 42; fed cohort, n = 42). In each study period, volunteers were assigned to receive a single oral dose of the generic or reference product (30 mg). Blood samples were collected before dosing and up to 72 hours after administration. The plasma concentration of nifedipine was determined by a validated liquid chromatography–tandem mass spectrometry method. Pharmacokinetic parameters were obtained using a noncompartmental model and log‐transformed pharmacokinetic parameters (maximum plasma concentration, area under the plasma concentration–time curve (AUC) from time 0 to the last measurable concentration, AUC from time 0 to infinity) were used to evaluate bioequivalence. The results showed that the 90% confidence interval for the geometric mean ratio of pharmacokinetic parameters of the test and reference products ranged from 80.0% to 125.0% in both the fasting and fed cohorts, meeting the criteria for bioequivalence. No serious adverse events were reported throughout the study and no adverse events led to withdrawal from the study. Food effects were found in both the test and reference products, with mean maximum plasma concentration, AUC from time 0 to the last measurable concentration, and AUC from time 0 to infinity increased by 23.7%, 20.7%, and 20.5%, respectively, for the test product and 35.2%, 13.4%, and 14.7% for the reference product after a high‐fat and high‐calorie breakfast.

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Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation

Cited by 8 publications

References 39 publications

Effect of Rhodomyrtus tomentosa Hassk. on HIF1α and VEGF expressions on hypertension placental

Effect of Rhodomyrtus tomentosa Hassk. on HIF1α and VEGF expressions on hypertension placental

Metabolism-involved drug interactions with traditional Chinese medicines in cardiovascular diseases

Pharmacokinetics and Bioequivalence of 2 Nifedipine Controlled‐Release Tablets: A Randomized, Single‐Dose, 2‐Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions

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