Context: HIF1α and VEGF are proteins marker oxidative stress and a decrease in placental growth factor (PlGF). Decreasing of HIF1α and VEGF in rats displayed poor trophoblast differentiation, placental abnormalities, and fetal mortality. Rhodomyrtus tomentosa is a flowering plant in the Myrtaceae family that has the potential to be a source of health-promoting chemicals. Aims: To analyze HIF1α and VEGF in serum and hypertension placental tissue after giving Rhodomyrtus tomentosa (RHO) leaves extract. Methods: Six treatments were given to the rats that were identified as being pregnant and pregnant rats with hypertension were given RHO with three doses: (a) normal pregnant rats (control); (b) hypertensive rats; (c) hypertensive rats + 100 mg/kg BW of RHO; (d) hypertensive rats +200 mg/kg BW of RHO; and (e) hypertensive rats + 400 mg/kg BW of RHO and (f) hypertensive rats + nifedipine. Under ketamine anesthesia, pregnant rats were removed on their 20th day of gestation. Immunohistochemistry and ELISA were used to assess HIF1α and VEGF protein expression. Results: There was a significant difference (p<0.01) in the expression of HIF1α and VEGF in the labyrinthine zone and yolk sac of the rat placenta between the normal (C-) and hypertensive (C+) groups. HIF1α and VEGF expression decreased when RHO was administered at doses ranging from 100 to 400 mg/kg BW. However, there was no significant change (p>0.05) in VEGF expression in the basal zone of the rat placenta across all groups. Conclusions: Rhodomyrtus tomentosa leaves extract decreases HIF1α and VEGF expressions in serum and repairs the tissue of the placenta's labyrinth, basal, and yolk sacs.
As one of the four largest insect orders, Hymenoptera are important pollinators, parasitoids, and predators in the agricultural sector. The objective of this research was to study the diversity and abundance of hymenoptera in the Forest Area with Special Purpose/KHDTK Aek Nauli, Simalungun Regency, North Sumatra, Indonesia. The insect sampling was conducted during the day and night using yellow and light trap technique. The results obtained a total of 13 species of Hymenoptera consisting of 45 ind. The relative abundance was recorded from 2.22 to 22.22 with the highest abundance from Vespula sp (Vespidae) and Sceliphron curvatum (Spechidae). The highest Importance Value Index (IVI) of Hymenoptera species was documented from Brachymyrmex sp. (Formicidae) at 115.56 and Polybia fastidiosuscula (Vespidae) at 106.67. The Shannon’s diversity (H’) of Hymenoptera ranged between 0.89 and 1.83 among sites or categorized as low-to-medium level of biodiversity with an evenness index (E) from 0.64 to 1.00. This finding may be noted as our first attempt in documenting the beta diversity of insects in the forest region.
Eighty mushroom species were collected during a field study at Conservative Forest in Batu Katak resort, Langkat regency, North Sumatera. Inventory was conducted by exploring four accessible paths and mushrooms were recorded for its identity and growth substrates. The most common mushroom species found in this study were lignicolous species, i.e. Polyporus, Marasmius, Schizophyllum, Trametes and Xylaria. The most utilized substrates for mushroom growth were dead logs which indicate a light-penetrated area of opened gap in forest favoring the growth of bracket fungi or lignicolous species. This baseline study may be used as data record for further mycological and laboratory studies. In addition, our records may be utilized as valuable information to local and foreign tourists who interest of mushroom picking and hunting in the future.
The learning model is one of the important parts in the world of education. Learning models with the involvement of play can help students understand mathematic and science. One method of play that can be used by elementary students is the Kotak Pas. Kotak Pas is a learning media that is easy to use, easy to carry or move to place. Kotak Pas is equipped with ten game books that contain mathematic and science. Each book has levels, from the easiest to the most difficult. Community service activities are carried out with several methods, namely conducting surveys and designing teaching materials, introducing Fitting Boxes, training teachers and students with Kotak Pas, and feedback.
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