Sheet of osteoblastic cells combined with platelet-rich fibrin improves the formation of bone in critical-size calvarial defects in rabbits

Wang, Zhifa; Hu, Hanqing; Li, Zhijin; Weng, Yanming; Dai, Taiqiang; Zong, Chunlin; Liu, Yanpu; Liu, Bin

doi:10.1016/j.bjoms.2015.12.015

Cited by 17 publications

(16 citation statements)

References 24 publications

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“…The fibrin gels made completely of platelets show high cell adhesion, proliferation 39 and bone repair. 40,41 However, the fibrin gel formed by activation of platelets is stable only for a few days. Rapid degradation of fibrin has been studied in various studies.…”

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confidence: 99%

Platelet-functionalized three-dimensional poly-ε-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors

Rampichová

Buzgo

Míčková

et al. 2017

IJN

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confidence: 99%

Platelet-functionalized three-dimensional poly-ε-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors

Rampichová

Buzgo

Míčková

et al. 2017

IJN

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“…It was proved to contain: transforming growth factor, (VEGF), (IGF-1),(PDGF-AB) , which help in the processes of stimulation of the BMMSC proliferation and differentiation in bone healing. (10,11) Radiographic results at 4 weeks post-operative, in groups A and B were similar (43.4-43.5% respectively). It was reported that complete healing of the femur shaft was only observed at 4 weeks in 5 mm segmental defect model in rats when used of H-BMMSCs/COL/n-HA/TCP (12) .…”

Section: Discussionmentioning

confidence: 74%

Freshly Isolated Versus Culture Expanded Bone Marrow Stem Cells in Healing of Bony Defects in DOGS

Al-Dahshan¹,

Al-Ahmady

Abu‐Seida

2020

ADJ-for Girls

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Purpose: this study was conducted between 2011 and 2017 at the faculty of Veterinary Medicine Cairo University and aimed to compare the efficiency of freshly isolated bone marrow (F-BMMSC) versus culture expanded bone marrow (E-BMMSC) when added to the mixture of autologous platelet rich fibrin (PRF), collagen with nanohydroxyapatite in healing of critical bony mandibular defects in mandibular site in dogs. Material and methods: 12 healthy adult Mongrel dogs were used in this study and bilateral mandibular critical bone defects (15X10 mm) were resected. Group A (The left side) contained: E-BMMSCs the expanded BMSC was seeded on collagen sponge with Nano-Hydroxyapatite and PRF membrane. Group B (The right side) contained: F-BMMSCs Gradient immediately separated BMSC seeded on the same scaffold. Radiographic follow up was done immediate, 4, 8, 12 weeks sacrificing was done 4, 8, 12 weeks postoperative. Local bone mineral densities (BMD) were measured on a DXA system. Histological evaluation was done using H&E. Results the results showed that group B right defects had better healing results than group A right defects all over the follow-up period, but the differences were not statically significant. Conclusion the study findings indicated that The F-BMMSCs that seeded in hydroxyapatite collagen type I HA-COL scaffolds combined with platelet rich fibrin PRF successfully repaired mandibular critical size defects, the same as the E-BMMSCs seeded in the same scaffold.

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“…The combination of PRF with cell therapy has shown promising results. In particular, the addition of PRF to human‐cultured bone‐derived periosteal sheet (Horimizu, Kubota, Kawase, Nagata & Kobayashi, ) and the addition of PRF to sheets of MSCs or to a composite of MSCs and nanoscale HA (Wang et al., ; Wang, Li, Guo, et al., ) increased the amount of regenerated bone in calvarial CSDs. The combination of MSCs with an autologous platelet‐rich fibrin glue and GBR in dog mandibular defects was also associated with significant more bone regeneration in comparison to empty defects, defects treated with GBR or with a combination of MSCs and platelet‐rich fibrin glue at 16 weeks (Liao, Chen, Chen, Chen & Tsai, ).…”

Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

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Sheet of osteoblastic cells combined with platelet-rich fibrin improves the formation of bone in critical-size calvarial defects in rabbits

Cited by 17 publications

References 24 publications

Platelet-functionalized three-dimensional poly-ε-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors

Platelet-functionalized three-dimensional poly-ε-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors

Freshly Isolated Versus Culture Expanded Bone Marrow Stem Cells in Healing of Bony Defects in DOGS

The use of bioactive factors to enhance bone regeneration: A narrative review

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Sheet of osteoblastic cells combined with platelet-rich fibrin improves the formation of bone in critical-size calvarial defects in rabbits

Cited by 17 publications

References 24 publications

Platelet-functionalized three-dimensional poly-&epsilon;-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors

Platelet-functionalized three-dimensional poly-&epsilon;-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors

Freshly Isolated Versus Culture Expanded Bone Marrow Stem Cells in Healing of Bony Defects in DOGS

The use of bioactive factors to enhance bone regeneration: A narrative review

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Platelet-functionalized three-dimensional poly-ε-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors

Platelet-functionalized three-dimensional poly-ε-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors