Platelet-functionalized three-dimensional poly-ε-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors

Hemocompatible and Bioactive Heparin‐Loaded PCL‐α‐TCP Fibrous Membranes for Bone Tissue Engineering

“…However, the incorporation of more heparin as a hemocompatible drug led to less attachments and spreading of platelets for (PCL‐1α)‐1hep and (PCL‐1α)‐2hep. These findings represented in other research which platelets were visible on the PCL scaffolds …”

Rotary jet spinning review – a potential high yield future for polymer nanofibers

“…103,104 Similar to tissue scaffolds, wound dressings are another biomedical application which has seen much focus, exploiting high surface areas within the nanofibers to foster the perfect conditions for cell growth, embryologic development, organogenesis, and wound repair. 105,106 Using RJS nanofibers in direct contact with the human body is only one aspect of the biomedical applications of nanofibers. Zhu et al 107 for example, have investigated affinity absorption materials by functionalizing poly(vinyl alcohol-co-ethylene) (PVA-co-PE) with Cibacron Blue F3GA to evaluate their effectiveness.…”

Three‐Dimensional Osteosarcoma Models for Advancing Drug Discovery and Development

“…[142,143] Fong et al used TC-71 cells to engineer an in vitro Ewing sarcoma model in a 3D PCL scaffold produced by electrospinning. [144,145] PCL scaffolds are frequently fabricated as fibrous structures applying the popular method used by Fong et al, electrospinning, which produces scaffolds with large porosity but small pores. The electrospun PCL scaffold showed an in vivo-like drug sensitivity to insulin-like growth factor-1 receptor and mTOR signaling pathway inhibitors as well as to doxorubicin, validating this platform for combinatorial therapies.…”

“…[142] Cultured cells acquired the natural phenotype found in vivo, revealing that this porous scaffold is able to mimic biochemical and morphological features, growth kinetics, and protein expression of human tumors. [142,145] Fused deposition molding, supercritical compression molding, freeze drying or gelation, centrifugal and melt-blown spinning are alternative methods that have been applied for tissue engineering. These remarkable results obtained for an Ewing sarcoma model can potentially be translated into an osteosarcoma model.…”

“…These remarkable results obtained for an Ewing sarcoma model can potentially be translated into an osteosarcoma model. [145] The scaffolds were functionalized with an interesting natural source of cytokines and growth factor, the blood platelets, to stimulate cell adhesion, proliferation, and osteogenic activity of osteosarcoma MG-63 cells. [144,145] PCL scaffolds are frequently fabricated as fibrous structures applying the popular method used by Fong et al, electrospinning, which produces scaffolds with large porosity but small pores.…”