Sharply higher rates of iron deficiency in obese Mexican women and children are predicted by obesity-related inflammation rather than by differences in dietary iron intake

Cepeda-Lopez, Ana C.; Osendarp, Saskia; Melse‐Boonstra, Alida; Aeberli, Isabelle; González-Salazar, Francisco; Feskens, Edith J. M.; Villalpando, Salvador; Zimmermann, Michael

doi:10.3945/ajcn.110.005439

Cited by 178 publications

(182 citation statements)

References 41 publications

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“…Recent data shows that weight loss in obese individuals is associated with a lower hepcidin level and therefore ann improvement in iron absorption [23]. This finding, however, was not confirmed in the current study.…”

Section: Discussioncontrasting

confidence: 57%

“…The responsible mechanism is not fully understood, but it is believed that an increased level of pro-inflammatory cytokines, such as C-reactive protein, activates hepcidin expression, consecutively leading to restriction in intestinal iron absorption and macrophage iron release through hepcidin downregulating influence on ferroportin-1 [22]. It is thought that hepcidin inhibits expression of ferroportin 1, limiting iron absorption in duodenum, and iron ex-flux from cells to the plasma [23]. In the population of obese women in the current study, the level of C-reactive protein was significantly higher than in the control group, which may be responsible for deterioration in iron homeostasis.…”

Section: Discussionmentioning

confidence: 99%

“…It is stated that increased body fat, especially visceral fat, predisposes towards worse iron homeostasis due to an increased rate of pro-inflammatory cytokines produced by visceral adipose tissue [20][21][22][23][24][25]. A large-scale study conducted on obese patients revealed also a positive correlation between TIBC and the percentage content of fat tissue.…”

Section: Discussionmentioning

confidence: 99%

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Iron status in obese women

Stankowiak-Kulpa¹,

Kargulewicz²,

Styszynski³

et al. 2017

Ann Agric Environ Med.

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Introduction and objective. A decreased concentration of iron, and consecutively haemoglobin, ferritin and decreased level of saturated transferrin, were observed in obese individuals more often than in healthy subjects. The purpose of this study was to determine whether iron, ferritin, transferrin saturation are significantly diminished in obese female patients compared to non-obese counterparts, and whether excess adiposity and inflammation were associated with depleted iron. Materials and methods. Female patients (n=48) diagnosed with obesity (BMI > 30 kg/m

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Iron status in obese women

Stankowiak-Kulpa¹,

Kargulewicz²,

Styszynski³

et al. 2017

Ann Agric Environ Med.

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show abstract

“…Esses resultados assemelham-se aos de um estudo transversal com amostra representativa de mulheres do México, que também identificou uma correlação negativa entre o consumo insuficiente do micronutriente e valores elevados do IMC (≥ 30kg/m 2 ), além de uma probabilidade de obesidade geral quase duas vezes maior entre mulheres com deficiência de ferro 11 . A gravidade desses resultados concentra-se sobretudo no fato de que, além de favorecer a obesidade, o consumo inadequado de ferro ainda contribui para a ocorrência da anemia, doença com importantes repercussões negativas à saúde.…”

Section: Variáveisunclassified

“…O que se observa na atualidade é um aumento do consumo calórico total advindo de um maior consumo de carboidratos simples e gorduras saturadas, em detrimento do consumo de alimentos fontes de micronutrientes essenciais 7 . Como resultados, pesquisas realizadas tanto em países de renda alta 8,9,10 quanto média 11,12 têm encontrado associações entre o consumo alimentar insuficiente de micronutrientes (cálcio, ferro, zinco, vitaminas A, C, D e E) e a condição de obesidade geral e/ou abdominal.…”

Section: Introductionunclassified

Relação entre consumo alimentar de vitaminas e minerais, índice de massa corporal e circunferência da cintura: um estudo de base populacional com adultos no Sul do Brasil

et al. 2017

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Resumo: O objetivo do estudo foi investigar a associação entre o consumo alimentar inadequado de micronutrientes e indicadores de obesidade geral e abdominal. Análise transversal, da segunda onda do estudo longitudinal EpiFloripa Adultos, incluindo 1.222 indivíduos de 22-63 anos, residentes em Florianópolis, Santa Catarina, Sul do Brasil. Os dados de consumo alimentar foram obtidos mediante aplicação de dois recordatórios de 24 horas, sendo o consumo habitual e as prevalências de inadequação no consumo de cálcio, ferro, zinco, e das vitaminas A, C, D e E estimadas conforme as recomendações do Instituto de Medicina e do Conselho Nacional de Pesquisa dos Estados Unidos. O estado nutricional de obesidade geral foi determinado considerando-se valores do índice de massa corporal (IMC), e a obesidade abdominal, considerando-se valores da circunferência da cintura (CC). Para a maioria dos micronutrientes investigados (cálcio, vitaminas A, C, D e E), as médias de consumo mostraram-se aquém dos valores recomendados, com prevalências elevadas de inadequação para toda a amostra. Somente a inadequação no consumo de vitamina C foi maior entre indivíduos obesos (geral ou abdominal). Além disso, associação inversa foi observada entre o menor consumo de cálcio e ferro com valores maiores do IMC e da CC, e entre o menor consumo das vitaminas A e D com valores maiores da CC (β = -0,92cm; IC95%: -1,76; -0,08 e β = -0,69cm; IC95%: -1,32; -0,06, respectivamente), principalmente entre adultos jovens. Foi possível identificar a existência de associação inversa entre o consumo alimentar inadequado de micronutrientes e o estado nutricional de obesidade geral e abdominal também em uma amostra de adultos residentes no Sul do Brasil.

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Obesity as malnutrition: The role of capitalism in the obesity global epidemic

Wells¹

2012

American J Hum Biol

109

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The global obesity epidemic remains poorly understood, partly because it has emerged alongside persisting under-nutrition in many populations. At an abstract level, obesity develops from exposure to the "obesogenic niche," comprising diverse factors predisposing to weight gain. This article first explores how susceptibility to the obesogenic niche is influenced by developmental and life-history experience. Human growth is sensitive to early-life ecological conditions, under the transducing effect of maternal phenotype. Such plasticity is associated with subsequent variability in body composition and metabolism, impacting susceptibility to the obesogenic niche, albeit with heterogeneity across populations. Both nutritional constraint and nutritional excess during early life are associated with variability in relevant molecular pathways. The article then considers the fundamental contribution of capitalist economics to population under-nutrition and over-nutrition. Historically, capitalism contributed to the under-nutrition of many populations through demand for cheap labor. As the limiting factor for economic growth switched to consumption, capitalism has increasingly driven consumer behavior inducing widespread over-nutrition. In populations undergoing nutritional transition, many individuals encounter both under- and over-nutrition within the life course, elevating both susceptibility and exposure to the obesogenic niche. The interactions between global economic forces and nutritional shifts are distributed across generations, and are strongly transduced by maternal effects. The structural connections between undernourished and overnourished worldwide and between under- and over-nutrition within individual life-courses highlight the central role of capitalist economics in the global obesity epidemic. Prevention policies targeting individual behavior have proved ineffective and economic policies are arguably the optimal target for intervention.

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Sharply higher rates of iron deficiency in obese Mexican women and children are predicted by obesity-related inflammation rather than by differences in dietary iron intake

Cited by 178 publications

References 41 publications

Iron status in obese women

Iron status in obese women

Relação entre consumo alimentar de vitaminas e minerais, índice de massa corporal e circunferência da cintura: um estudo de base populacional com adultos no Sul do Brasil

Obesity as malnutrition: The role of capitalism in the obesity global epidemic

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