Shape-Controlled Synthesis of Luminescent Hemoglobin Capped Hollow Porous Platinum Nanoclusters and their Application to Catalytic Oxygen Reduction and Cancer Imaging

Abstract

Engineering hollow and porous platinum nanostructures using biomolecular templates is currently a significant focus for the enhancement of their facet-dependent optical, electronic, and electrocatalytic properties. However, remains a formidable challenge due to lack of appropriate biomolecules to have a structure-function relationship with nanocrystal facet development. Herein, human hemoglobin found to have facet-binding abilities that can control the morphology and optical properties of the platinum nanoclusters (Pt NCs) by regulation of the growth kinetics in alkaline media. Observations revealed the growth of unusual polyhedra by shape-directed nanocluster attachment along a certain orientation accompanied by Ostwald ripening and, in turn, yield well-dispersed hollow single-crystal nanotetrahedrons, which can easily self-aggregated and crystallized into porous and polycrystalline microspheres. The spontaneous, biobased organization of Pt NCs allow the intrinsic aggregation-induced emission (AIE) features in terms of the platinophilic interactions between Pt(II)-Hb complexes on the Pt(0) cores, thereby controlling the degree of aggregation and the luminescent intensity of Pt(0)@Pt(II)−Hb core−shell NCs. The Hb-Pt NCs exhibited high-performance electrocatalytic oxygen reduction providing a fundamental basis for outstanding catalytic enhancement of Hb-Pt catalysts based on morphology dependent and active site concentration for the four-electron reduction of oxygen. The as-prepared Hb-Pt NCs also exhibited high potential to use in cellular labeling and imaging thanks to the excellent photostability, chemical stability, and low cytotoxicity.

Nanotechnology Involved in Treating Urinary Tract Infections: An Overview

“…Therefore, it would be an easy method of identifying Escherichia coli strains in a rapid and effective manner even at a low Escherichia coli concentration of only 8.3 × 103 CFU/mL. The Hb-FeQCs are also water-soluble, stable, biocompatible, and highly sensitive to bacterial concentrations, especially in the urine medium [ 193 , 194 , 195 ].…”

PtII(C^N)(N-donor ligand)Cl-type complexes showing highly sensitive aggregation-induced phosphorescence emission (AIPE) behavior fulfilled by long-size ligands and a distorted molecular configuration

“…19 Bipyridine-Pt( ii )-alkynyl complexes with AIPE behavior can show decent EL performances with a maximal external quantum efficiency ( η ext ) of 5.8% and a current efficiency ( η L ) of 18.4 cd A −1 , 20 while Pt( ii ) diimine acetylide complexes with good AIPE nature can act as effective optical power limiters. 21–23 Recently, AIPE behaviors have been found in Pt II (C^N)(N-donor ligand)Cl-type complexes to show great potential in mesoporous emissive materials, 24 cell labels, 25 high performance OLEDs 26 etc . Importantly, it has been found that AIPE-active Pt II (C^N)(N-donor ligand)Cl-type complexes involve a new AIE mechanism called restrained D 2d deformation of the coordinating skeleton of these complexes from square-planar ( D 4h ) in the ground states to a tetrahedral ( T d ) skeleton in the excited states.…”

Inhibiting Hypoxia and Chemotherapy-Induced Cancer Cell Metastasis under a Valid Therapeutic Effect by an Assistance of Biomimetic Oxygen Delivery

“…Hemoglobin (Hb) is one of the main components of red blood cells and is characterized as iron-rich, and it can reversibly combine oxygen molecules and release the molecules into tissues according to the oxygen level . Over the past decades, Hb-based oxygen carriers (HBOCs) have gained widespread attention, , and various types of HBOC have been developed, such as glutaraldehyde-polymerized Hb and polyethylene glycol-conjugated Hb (PEG-Hb). , Herein, we designed an artificial oxygen carrier system, a Hb loaded liposome (Hb@lipo), which presented a stable Hb encapsulation and high oxygen binding ability. Moreover, we developed a liposome containing cabazitaxel (CBZ@lipo), a chemotherapeutic agent belonging to the taxane class.…”