Sexually transmitted coinfections in patients with anogenital warts – a retrospective analysis of 196 patients

Abstract

Background and objectives: Anogenital warts (AGWs) are most commonly caused by low-risk human papillomavirus (HPV) types, and although they are the most frequent viral sexually transmitted infections (STIs), little is known about STI coinfections in affected patients. We therefore sought to assess STI coinfection rates in patients with AGW, specify STI coinfections and calculate the number needed to screen (NNS) for each STI. Methods:A retrospective cross-sectional study analyzing data sets from AGW patients treated in our clinic between 2008-2016.Results: 142/196 (72 %) patients had been variably screened for infections with HIV, HBV and HCV, Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium and HSV. The STI coinfection rate in all tested patients was 24.6 %, yielding an NNS of 4.1 to detect any STI. Of note, the coinfection rate did not differ significantly between heterosexual men, homosexual men and women, respectively. The NNS for syphilis was 8.4, for HIV 14.0, for HCV 28.5 and for HBV 39.0. The NNS for asymptomatic patients tested for HSV, Chlamydia trachomatis and Mycoplasma genitalium were 1.4, 5.3 and 12.0, respectively.Conclusion: Due to the high prevalence of STI coinfections, AGW patients should be screened for other STIs.

HIV and Sexual Dysfunction in Men

“…Finally, the sexual dysfunction in HIV-infected men could be further enhanced by STDs recurrences, which are also directly related to infertility and subfertility [ 174 , 190 ]. Indeed, co-infection with multiple pathogens is common worldwide in people living with HIV [ 191 , 192 , 193 , 194 , 195 ]. Among these, several SDTs could lead to physical consequences, both anatomical, hormonal and neurological, which can further aggravate sexual dysfunction.…”

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts

“…Despite the fact that the low-risk human papillomavirus types (6 and 11) are considered the main causes of the benign types of AGWs, the high-risk types (16 and 18) are linked to around 70% of cervical malignancies globally. 1,2 Most destructive therapeutic techniques traditionally employed to treat AGWs cause discomfort and have demoralizingly high recurrence rates. 3 However, due to their excellent safety profile and low recurrence rate, immunotherapies have received medical attention in the treatment of genital warts; therefore, the hunt for a novel therapeutic option is still ongoing.…”

“…Despite the fact that the low-risk human papillomavirus types (6 and 11) are considered the main causes of the benign types of AGWs, the high-risk types (16 and 18) are linked to around 70% of cervical malignancies globally. 1,2…”

Evaluation of the knowledge of students concerning sexually transmitted infections in Bavaria/Germany (a cross‐sectional study)

“…Vaccination rates and willingness of girls and boys to be vaccinated against human papilloma viruses (HPVs) are also worrying: In 2015, the rate was 31.1 % for 15 year-old girls with a fully completed vaccination series in Germany [11], although numerous current studies underpin the protective effect of this vaccination against cervical cancer and associated anogenital tumors [12][13][14]. The incidence of cervical cancer in women was 4,380 in Germany in 2016 (10.5 per 100,000) [15]. In countries with HPV vaccination programs, the rates of anogenital tumors have declined significantly.…”