Sexual Precocity

Jolly, Hugh

doi:10.1177/003591575104400612

Cited by 5 publications

(3 citation statements)

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“…The clinical features of precocious puberty outlined above are essentially the same as those described by other authors (2,3). As noted in other series, acceleration of growth is one of the earliest features of precocious puberty and at the time of diagnosis bone age was already significantly advanced in all our patients.…”

Section: Discussionsupporting

confidence: 88%

Isosexual Precocious Puberty in Girls

1985

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This paper reviews the clinical findings, pituitary gonadotrophin reserve and plasma oestradiol, neurological findings and pelvic ultrasound appearance in 47 girls with precocious puberty starting before the age of 7 years. Of the 39 girls who had air encephalograms or cranial CT scans, 19 showed intracranial abnormalities (hamartomas 11; hydrocephalus 5; optic glioma 2; arachnoid cyst 1). There was no significant difference in the peak serum luteinizing hormone and follicle-stimulating hormone responses to intravenous gonadotrophin stimulating hormone in girls with and without intracranial lesions. Pelvic ultrasound examination showed development of the ovaries, uterus, and vagina similar to that seen in normal puberty. Treatment with cyproterone acetate (50-100 mg/day) in 26 girls resulted in arrest of breast development and suppression of menstruation, but a definite effect on growth was not documented.

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