Isosexual Precocious Puberty in Girls

Lyon, A; Bruyn, Rose de; Grant, D B

doi:10.1111/j.1651-2227.1985.tb10063.x

Cited by 18 publications

(11 citation statements)

References 13 publications

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“…Individuals with precocious puberty usually fail to achieve a final height which is adequate to their target height. Although several regimens of hormonal treat¬ ment have been introduced in the past (Greenblatt et (Bossi et al 1973;Greenblatt et al 1971;Helge et al 1969;Kauli et al 1976;Kupperman & Epstein 1962;Lyon et al 1985;Menking et al drugs with respect to arrest and reversal of the development of secondary sexual characteristics.…”

mentioning

confidence: 99%

The effects of cyproterone acetate on statural growth in children with precocious puberty

Sorgo

Király

Homoki

et al. 1987

Acta Endocrinologica

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Forty-four patients (42 f, 2 m) with precocious puberty (31 idiopathic, 1 familial, 7 cerebral, 5 McCune-Albright) were treated with cyproterone acetate for periods of 1\p=n-\8.75 years in different (P < 0.05) daily dosages of 117 \m=+-\6.1 mg/m2 per day (\l =x_\\ m=+-\sem, group A, N = 20) and 60.8 \m=+-\ 2.42 mg/m2 per day (group B, N = 24). Thirty-three girls had experienced menarche before therapy at a mean age of 4.89 \m=+-\0.42 years. Treatment was started at a chronologic age of 5.45 \m=+-\0.33 years in the girls and 5.74 \m=+-\1.34 years in the boys. At the time of evaluation, 31 of our patients had reached final height. With respect to the effects of treatment on statural growth, the Standard Deviation Scores were retrospectively determined for height, weight, and growth velocity. The initial Bayley-Pinneau height predictions were compared with final height and target height, and the skeletal maturation was studied.

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mentioning

confidence: 99%

The effects of cyproterone acetate on statural growth in children with precocious puberty

Sorgo

Király

Homoki

et al. 1987

Acta Endocrinologica

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“…A nossa paciente com hamartoma não tinha qualquer sintoma neurológico, o que tem sido descrito na maioria das vezes. 12,13 Nesta série de casos as meninas com lesão cerebral apresentaram progressão rápida dos caracteres sexuais, finalizando em pouco tempo com menarca e necessitando de tratamento. Não houve, porém, nenhuma clara diferença entre as meninas com e sem lesão cerebral quanto ao padrão de secreção de gonadotropinas após LHRH.…”

Section: Discussionunclassified

“…Na literatura não tem sido observada diferença nem em relação à evolução dos caracteres sexuais nem em relação às gonadotropinas, nas meninas com lesão cerebral. 13 Tabela 4 -Foram considerados normais os volumes de até mais 2SD da média, isto é, até 2,2 cm 3 para o volume uterino (VU) e até 1,7 cm 3 para o volume ovariano (VO). 13 Em 3 casos um ovário não foi visualizado (NV) e em 1 caso não foi possível medir seu volume (NM).…”

Section: Discussionunclassified

Study of true precocius puberty in girls using clinical, laboratorial and imaging techniques

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Mm³

et al. 1995

J Pediatr (Rio J)

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This paper reviews the clinical findings, pituitary gonadotrophin reserve, plasma estradiol and androgens, radiological findings and pelvic ultrasound appearance in 17 girls with true precocious puberty (PP), and attempts to asses the value of these tests diagnosis in the clinical management of such patients and better understanding of the pathogenesis of this disorder. As noted in other series, acceleration of growth is one of the earliest features of PP and at the time of diagnosis bone age can be already significantly advanced. In 3 (18%) patients intracranial abnormalities were present. Ultrasound examination showed changes similar to those seen during normal puberty. To conclude, the introduction of hight-resolution methods (CT scan and RM) and techniques for ultrasound examination have greatly simplefied the clinical investigation of female precocious puberty.J. pediatr. (Rio J.). 1995; 71(1):36-40: female precocious puberty, clinical features, hormone levels, radiological findings, ultrasound examination. ResumoEste estudo tem como finalidade rever as principais características clínicas, a reserva de gonatropinas hipofisárias, os níveis de estradiol e androgênios, os achados radiológicos e ultrasonográficos em meninas com puberdade precoce verdadeira para determinar o valor desses métodos diagnósticos no manejo clínico de tais pacientes e melhor compreender a patogênese dessa desordem. Como observado em outras séries, a aceleração do crescimento é uma das primeiras características da PPV e a idade óssea já pode estar significativamente avançada no diagnóstico. Em três pacientes (18%) foi evidenciada presença de lesão intracraniana. A USG pélvica mostrou mudanças similares àquelas vistas na puberdade normal. Concluímos que a introdução de métodos de imagem de alta resolução (TC e RM de crânio) e da USG pélvica simplificou a investigação clínica da PPV em meninas. J. pediatr. (Rio J.). 1995; 71(1):36-40:puberdade precoce em meninas, características clínicas, níveis hormonais, achados radiológicos, ultra-sonografia pélvica.A precocidade sexual é difinida como o desenvolvimento de um ou mais caracteres sexuais secundários antes da idade de oito anos, em meninas. 1,2,3,4,5 Porém, alguns autores definem como patológica a presença dos caracteres sexuais secundários antes de seis anos e da menarca antes de oito anos, e chamam de puberdade prematura quando o desenvolvimento sexual ocorrer entre seis e oito anos ou a menarca, entre os oito e dez anos de idade. 6 Quando a precocidade sexual ocorre devido à maturação do eixo hipotálamo-hipófise-gonadal, a síndrome é descrita como Puberdade Precoce Verdadeira (PPV), Central ou Completa. Quando a secreção de gonadotropinas e/ou secreção de hormônios sexuais ocorre independentemente do controle hipotalâmico-hipofisário chamamos de Pseudopuberdade Precoce ou Puberdade Precoce Periférica ou Incompleta. Manifestações isoladas do desenvolvimento sexual são denominadas de Variantes do Desenvolvimento Puberal: Telarca, Pubarca e Menarca Precoces. 1,3,4,5 As principais...

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“…Other workers [11,29] have administered the daily dose in two or three divided doses. We have recently described the effectiveness of our dose regimen on the arrest and regression of secondary sexual characteristics [15]. All doses were related to surface area and are given in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…We have recently reported our clinical, neuroradiological and gonadotrophin findings in children with central precocious puberty treated with cyproterone acetate [15] and ob- Abbreviation: GnRH = gonadotrophin releasing hormone served no definite effect on growth. We report here a detailed growth analysis of 13 children with central precocious puberty treated with cyproterone acetate for mean periods in excess of 4 years in girls and 5 years in boys.…”

Section: Introductionmentioning

confidence: 98%

The effect of cyproterone acetate on the growth of children with central precocious puberty

et al. 1987

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We have examined the growth and skeletal maturation of 19 children (6 male, 13 female) with central precocious puberty. The aetiology in nine patients (5 male, 4 female) was secondary to a hypothalamic hamartoma. Six children (2 male, 4 female) received no treatment whereas 13 children (4 male, 9 female) were treated with cyproterone acetate in a mean dose of 68 mg/m2 per day (range, 34-260) for a mean duration of 4.5 years (range, 0.8-7.9). There was no significant difference between height SDS for bone age at the beginning and end of observation in either treated or untreated groups. No significant relationship between the mean dose of cyproterone acetate used and change in height SDS for bone age could be determined. We conclude that cyproterone acetate has no beneficial effect on the growth prognosis of children with central precocious puberty.

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Isosexual Precocious Puberty in Girls

Cited by 18 publications

References 13 publications

The effects of cyproterone acetate on statural growth in children with precocious puberty

The effects of cyproterone acetate on statural growth in children with precocious puberty

Study of true precocius puberty in girls using clinical, laboratorial and imaging techniques

The effect of cyproterone acetate on the growth of children with central precocious puberty

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