Sexual Function in Females With Rheumatoid Arthritis: Relationship With Physical and Psychosocial States

Abda, Essam A.; Selim, Zahra I.; Teleb, Samia M; Zaghira, Mahmoud; Fawzy, Mohamed; Hamed, Sherifa A.

doi:10.5606/archrheumatol.2016.5838

Cited by 10 publications

(20 citation statements)

References 38 publications

(52 reference statements)

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“…Regarding psychological variables, mood and some psychiatric disorders such as depression impact the self-esteem of patients, which is finally observable as low socialization with others and the difficulties in maintaining an emotional relationship. 5 , 8 , 23 These findings are in agreement with those found in this study because a quite important association was identified with the presence or history of depression or anxiety.…”

Section: Discussionsupporting

confidence: 92%

Prevalence of Sexual Disorders in Patients With Rheumatoid Arthritis and Associated Factors

Santos-Moreno¹,

Castro²,

Villarreal³

et al. 2020

Sexual Medicine

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Introduction Rheumatoid arthritis (RA) is a chronic and progressive pathology, present in between 0.5% and 1% of adults. Sexual disorders (SDs) occur in between 31% and 70% of all patients with RA. Aim To establish the associated risk factors and the prevalence of SDs in a group of patients with RA. Methods An analytical cross-sectional study was performed, evaluated with the Diagnostic and Statistical Manual of Mental Disorders-V tool. The related factors and the activity of the disease were explored. A multivariate logistic regression analysis was conducted. Main Outcome Measure The prevalence of SDs was 29.6%. There was an association between the presence of SDs and gender (women; odds ratio [OR]: 0.6, 95% CI: 0.4–0.8), age (OR: 1.4, 95% CI: 1.1–1.8), psychological alterations (OR: 12.1, 95% CI: 5.9–27.2), and Disease Activity Score 28 (OR: 1.6, 95% CI: 1.2–2). Results A total of 1,436 patients, with a median age of 56 years, were analyzed. Conclusion SDs are present in a third of patients with RA. Among the factors associated with SDs were the activity of the disease, presence of mood disorders, psychiatric disorders, alcoholism, and concomitant autoimmune pathologies. These findings suggest the necessity of a multidisciplinary approach to properly manage RA, as well as an enhancement in communication channels between the health professional team and the patient. Santos-Moreno P, Castro CA, Villarreal L, et al. Prevalence of Sexual Disorders in Patients With Rheumatoid Arthritis and Associated Factors. Sex Med 2020;8:510–516.

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Section: Discussionsupporting

confidence: 92%

Prevalence of Sexual Disorders in Patients With Rheumatoid Arthritis and Associated Factors

Santos-Moreno¹,

Castro²,

Villarreal³

et al. 2020

Sexual Medicine

View full text Add to dashboard Cite

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“…[5][6][7][8] The prevalence of RA is about 3 times higher in females than males. [9][10][11] The pathogenesis of RA is complex and involves an intricate interplay between host factors (eg genetic susceptibilities, aberrant immune response, abnormal metabolic enzymes and sex hormones) and environmental triggers (eg bacterial or viral infection).…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNAs in rheumatoid arthritis

Zheng

Jiang

et al. 2017

Cell Proliferation

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Rheumatoid arthritis, a disabling autoimmune disease, is associated with altered gene expression in circulating immune cells and synovial tissues. Accumulating evidence has suggested that long non-coding RNAs (lncRNAs), which modulate gene expression through multiple mechanisms, are important molecules involved in immune and inflammatory pathways. Importantly, many studies have reported that lncRNAs can be utilized as biomarkers for disease diagnosis and prognostication. Recently, dysregulation of lncRNAs in rheumatoid arthritis and other autoimmune diseases has been revealed. Experimental studies also confirmed their crosstalk with matrix metalloproteinases, nuclear factor-κB signalling and T-cell response pertinent to autoimmunity and inflammation. Circulating lncRNAs, such as HOTAIR, differentiated patients with rheumatoid arthritis from healthy subjects. Taken together, lncRNAs are good candidates as biomarkers and therapeutic targets in rheumatoid arthritis. Further investigation on in vivo delivery of these regulatory molecules and large-cohort validation of their clinical applicability may be useful.

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“…Depression, anxiety and adjustment disorder were the common conditions found among RA patients. They found that all domains of sexual function were grossly affected among these patients and disease duration and severity were the main predictors of sexual dysfunction among these patiants 7 . Chancey et al in 2019 discussed the types of pain among the women suffering from RA and the psychosocial impact of pain as well.…”

Section: Introductionmentioning

confidence: 96%

Sexual Dysfunction Among Female Patients of Rheumatoid Arthritis: An Under Addressed Phenomenon

Hussain

Fakhr

Mumtaz

et al. 2021

PAFMJ

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Objective: To determine the sexual dysfunction among the patients of rheumatoid arthritis and assess the relationship of various factors with presence of sexual dysfunction among the target population. Study Design: Cross sectional study. Place and Duration of Study: Rheumatology department, Pak Emirates Military Hospital Rawalpindi Pakistan, from Aug 2019 to Apr 2020. Methodology: The sample population comprised of 350 married female patients of rheumatoid arthritis between the age of 18 and 45 years, reporting for the routine follow-up at rheumatology department a tertiary care hospital. Sexual function was assessed using the female sexual function index (FSFI). Relationship of age, duration of rheumatoid arthritis, presence of comorbidities and polypharmacy was assessed with the sexual dysfunction among the target population. Results: Mean age of the study participants was 31.15 ± 4.22 years. Out of 350 women suffering from rheumatoid arthritis screened through female sexual function index, 172 (49.1%) had normal sexual function while 178 (50.9%) had sexual dysfunction. After applying the chi-square test, we found that polypharmacy and long duration of illness had significant association with the sexual dysfunction. Conclusion: High reporting of sexual dysfunction among the women suffering from rheumatoid arthritis indicates that this has been a neglected phenomenon by the physicians and researchers and may be added in routine screening. Women with long duration of illness and those managed with more than one drugs should be focused more while screening for sexual problems.

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Sexual Function in Females With Rheumatoid Arthritis: Relationship With Physical and Psychosocial States

Cited by 10 publications

References 38 publications

Prevalence of Sexual Disorders in Patients With Rheumatoid Arthritis and Associated Factors

Prevalence of Sexual Disorders in Patients With Rheumatoid Arthritis and Associated Factors

Long non‐coding RNAs in rheumatoid arthritis

Sexual Dysfunction Among Female Patients of Rheumatoid Arthritis: An Under Addressed Phenomenon

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