Sexual function and depressive symptoms in young women with thyroid autoimmunity and subclinical hypothyroidism

This meta-analysis establishes the association between AIT and depression and anxiety disorders. Patients with AIT exhibit an increased chance of developing symptoms of depression and anxiety or of receiving a diagnosis of depression and anxiety disorders. This finding has important implications for patients and could lead to the choice of early treatment-and not only psychotherapeutic treatment-of the organic disorder.

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“…Figure 2 shows the overall association of AIT with symptoms of depression. 17,19,21,23,25,27,37,38,[52][53][54][55][56][57][58][59][60][61][62]…”

Section: Meta-analytic Association Between Ait and Depressionmentioning

confidence: 99%

Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis

et al. 2018

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“…Interestingly, in our recent study, only sexual desire was disturbed in young women with macroprolactinaemia, which contrasted with multidimensional impairment of sexual function in women with elevated monomeric prolactin, probably because the amount of monomeric prolactin released locally from macroprolactin complexes is lower than that found in patients with monomeric hyperprolactinaemia [39]. Furthermore, apart from arousal, only desire was disturbed among all groups of women with thyroid disease: women with euthyroid Hashimoto's thyroiditis, non-autoimmune hypothyroidism, and autoimmune thyroid hypofunction [40]. All these findings taken together suggest that desire may be particularly susceptible to even small changes in metabolism or hormone balance.…”

Section: Discussionmentioning

confidence: 76%

Funkcjonowanie seksualne i objawy depresyjne u kobiet z różnymi typami stanu przedcukrzycowego — badanie pilotażowe

Krysiak

Drosdzol–Cop

Skrzypulec-Plinta

2018

Endokrynologia Polska

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Introduction: No previous study has investigated sexual functioning in prediabetic women. This study was aimed at investigating sexual function in young women with various types of prediabetes. Material and methods:The study included four groups of women: women with isolated impaired fasting glucose (Group A; n = 19), isolated impaired glucose tolerance (Group B; n = 18), presence of both impaired fasting glucose and impaired glucose tolerance (Group C; n = 18), as well as matched healthy controls (Group D; n = 19). All participants completed questionnaires evaluating sexual function (Female Sexual Function Index -FSFI) and the presence and severity of depressive symptoms (Beck Depression Inventory-Second Edition -BDI-II). Results:The total FSFI and BDI-II scores were lower in Group C than in the remaining groups of women, while the total FSFI score was lower in Groups A and B than in Group D. Patients with both impaired fasting glucose and impaired glucose tolerance had lower scores in all domains (sexual desire, arousal, lubrication, orgasm, sexual satisfaction, and dyspareunia). Compared to Group D, Group A was characterised by lower domain scores for sexual desire and sexual satisfaction, and Group B by lower domain scores for desire, arousal, and orgasm. In all groups of prediabetic women, the overall FSFI score correlated negatively with the degree of insulin resistance and weakly with the total BDI-II score. Conclusions: Impaired fasting glucose and impaired glucose tolerance may disturb sexual functioning and induce depressive symptoms.

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“…'nın yaptığı ve Beck depresyon ölçeği'nin kullanıldığı bir çalışmada ise subklinik hipotiroidisi olan 17 hastanın %59'unda depresif semptomlara rastlanırken aynı çalışmada ötiroid Hashimoto tanısı alan hastalarda hastalarda depresif semptom oranı %37 olarak bulunmuştur. 14 Siegmann ve ark. 'nın yaptığı bir meta analizde otoimmün tiroiditi olan hastalarda depresyon ve anksiyete bozuklukları araştırılmıştır.…”

Section: Discussionunclassified

Evaluation Depressive Symptoms in Patients with Euthyroid Hashimoto’s Thyroiditis and Patients with Subclinical Hypothyroidism

Çaklılı¹

2019

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi

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ÖzAmaç: Hipotiroidi toplumda en sık görülen endokrinolojik hastalıklardan birisidir. Bu çalışmada, Hashimoto hipotiroiditine bağlı tedavi atında ötiroid olan hastalar ile subklinik hipotirodi tanısı alan hastalarda depresif semptom varlığı araştırılarak sağlıklı kontroller ile karşılaştırıldı. Yöntem: Bu çalışma Kocaeli Devlet Hastanesi İç Hastalıkları Kliniği'nde 2017-2019 yılları arasında yürütüldü. Kocaeli Devlet Hastanesi İç Hastalıkları Kliniği'nde tiroid hastalığı nedeni ile takip edilen hastalar, tiroid fonksiyon testi sonuçlarına göre tedavi altında ötiroid olan Hashimoto tiroiditi olanlar ve subklinik hipotiroidisi olanlar şeklinde ikiye ayrıldı. Her iki gruba da Beck depresyon ölçeği uygulandı. Ayrıca bir kontrol grubu oluşturularak aynı ölçek uygulandı. Bulgular: Çalışmaya toplam 43 hasta ve 31 kontrol alındı. Bunlardan 32'si ötiroid seyreden Hashimoto tiroiditi olan, 11'i de subklinik hipotiroidisi olan hastalardı. Ötiroid hastaların ortalama tiroid stimulan hormon (TSH) düzeyi 2,3±0,9 mU/L iken subklinik hipotiroidisi olan hastalarınki 8,2±2,7 mU/L idi. Hastaların ortalama Beck depresyon skoru 14,1±8,9 idi. Kontrol grubunun ortalama Beck depresyon skoru 6,4±5,2 olarak saptandı. Kontrol grubu ile ötiroid Hashimoto grubu arasında Beck depresyon skoru açısından anlamlı fark saptanırken (p<0,01), ötiroid Hashimotolu hastalar ile subklinik hipotiroidisi olanlar arasındaki fark anlamlılık arz etmedi. Toplam 15 hastanın (%35) depresyon skoru ≥17 olarak saptandı. Ötiroid hastaların %34'ünde (n=11), subklinik hipotiroidisi olan hastaların %36'sında (n=4) orta ve yüksek seviyede depresif semptomlar görüldü. Sonuç: Depresyon hipotiroidi hastalarında nadir görülen bir durum değildir. Gerekli durumlarda araştırılmalıdır. AbstractObjective: Hypothyroidism is a common endocrine disorder in general population. This study aims to compare depressive symptoms of patients with euthyroid Hashimoto hypothyroidism, patients with new onset subclinical hypothyroidism and healthy controls. Methods: Study was conducted at Kocaeli State Hospital Internal Medicine Clinic between 2017-2019. Patients who were treated for hypothyroidism at Kocaeli State Hospital Internal Medicine Clinic were screened and eligible patients were divided into two groups: patients with euthyroid Hashimoto thyroiditis and patients with subclinical hypothyroidism. Beck depression inventory was applied to the groups. Also, a control group was generated and applied the same inventory. Results: Forty-three patients and 31 healthy controls were recruited; 32 had euthyroid Hashimoto thyroiditis whereas 11 had subclinical hypothyroidism. Mean thyroid stimulating hormone (TSH) level of patients was 2.3±0.9 mU/L and 8.2±2.7 mU/L, respectively. Mean Beck depression inventory score of the patients was 14.1±8.9. Mean score of the control group was 6.4±5.2. Although there was no difference between scores of controls and subclinical hypothyroid patients, there was statistically significant difference between controls and euthyroid patients (p<0.01). There was no stat...

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Sexual function and depressive symptoms in young women with thyroid autoimmunity and subclinical hypothyroidism

Abstract: The obtained results suggest that both thyroid autoimmunity and mild thyroid failure, particularly if they occur together, may negatively affect female sexual function and depressive symptoms.

Cited by 50 publications

References 31 publications

Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis

Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis

Funkcjonowanie seksualne i objawy depresyjne u kobiet z różnymi typami stanu przedcukrzycowego — badanie pilotażowe

Evaluation Depressive Symptoms in Patients with Euthyroid Hashimoto’s Thyroiditis and Patients with Subclinical Hypothyroidism

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