Funkcjonowanie seksualne i objawy depresyjne u kobiet z różnymi typami stanu przedcukrzycowego — badanie pilotażowe

Abstract

Introduction: No previous study has investigated sexual functioning in prediabetic women. This study was aimed at investigating sexual function in young women with various types of prediabetes. Material and methods:The study included four groups of women: women with isolated impaired fasting glucose (Group A; n = 19), isolated impaired glucose tolerance (Group B; n = 18), presence of both impaired fasting glucose and impaired glucose tolerance (Group C; n = 18), as well as matched healthy controls (Group D; n = 19). All participants completed questionnaires evaluating sexual function (Female Sexual Function Index -FSFI) and the presence and severity of depressive symptoms (Beck Depression Inventory-Second Edition -BDI-II). Results:The total FSFI and BDI-II scores were lower in Group C than in the remaining groups of women, while the total FSFI score was lower in Groups A and B than in Group D. Patients with both impaired fasting glucose and impaired glucose tolerance had lower scores in all domains (sexual desire, arousal, lubrication, orgasm, sexual satisfaction, and dyspareunia). Compared to Group D, Group A was characterised by lower domain scores for sexual desire and sexual satisfaction, and Group B by lower domain scores for desire, arousal, and orgasm. In all groups of prediabetic women, the overall FSFI score correlated negatively with the degree of insulin resistance and weakly with the total BDI-II score. Conclusions: Impaired fasting glucose and impaired glucose tolerance may disturb sexual functioning and induce depressive symptoms.

Prevalence and predictors of female sexual dysfunction among sexually active women in the diabetes prevention program outcomes study

“…4 In one study of women with PreD, concomitant impaired fasting glucose, and impaired glucose tolerance were associated with the greatest risk of sexual dysfunction and depressive symptoms. 57 Additionally, it has been well described that patients may experience some disturbance of sexual function associated with antidepressants due to the modification induced on the neurotransmitter systems of the brain. 58,59 4…”

MANAGEMENT OF ENDOCRINE DISEASE: Female sexual dysfunction for the endocrinologist

“…In these regards, the psychological consequences of diabetes should not be underestimated: quality of life is severely affected by diabetes and its complications (103), and among diabetic patients, depression is seemingly more prevalent in females (104,105,106). Furthermore, depression in diabetic and pre-diabetic patients, measured via the Beck Depression Inventory scale, negatively correlates with the FSFI score (107,108). Interestingly, metformin treatment aimed to improve glycemic control has also shown positive effects on the different domains of the FSFI, most notably on sexual desire and sexual satisfaction (109).…”

Modern Aspects of the Clinic, Diagnosis and Treatment of Prediabetes

“…Во всех группах женщин, страдающих предиабетом, общий балл FSFI отрицательно коррелировал со степенью резистентности к инсулину и слабо с общим баллом BDI-II. Ученые пришли к выводу о том, что нарушение глюкозы натощак и НТГ могут нарушать сексуальное функционирование и вызывать депрессивные симптомы у женщин [43]. Люди, имеющие социальную активность, менее склонны к развитию ненормальной регуляции глюкозы.…”