Sex-Specific Threshold Levels of Plasma B-Type Natriuretic Peptide for Prediction of Cardiovascular Event Risk in a Japanese Population Initially Free of Cardiovascular Disease

Nakamura, Motoyuki; Tanaka, Fumitaka; Takahashi, Tomohiro; Makita, Shinji; Ishisone, Takenori; Onodera, Masayuki; Ishibashi, Yutaka; Itai, Kazuyoshi; Onoda, Toshiyuki; Ohsawa, Masaki; Tanno, Kozo; Sakata, Kiyomi; Omama, Shinichi; Ogasawara, Kuniaki; Kuribayashi, Toru; Okayama, Akira

doi:10.1016/j.amjcard.2011.07.011

Cited by 12 publications

(15 citation statements)

References 17 publications

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“…men but not women. Women exhibit higher BNP values than men, even in the absence of cardiovascular diseases, and have a lower stroke incidence [8,9]. The higher physiological BNP values may explain why it is difficult to detect a predictive role of BNP in women.…”

Section: Discussionmentioning

confidence: 99%

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B‐type natriuretic peptide predicts stroke of presumable cardioembolic origin in addition to coronary artery calcification

Kara

Gronewold

Neumann

et al. 2014

Euro J of Neurology

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Section: Discussionmentioning

confidence: 99%

“…In addition to traditional risk factors, BNP was found to predict myocardial infarcts and death in subjects with [5][6][7] and without [8,9] pre-existing coronary heart disease.…”

Section: Introductionmentioning

confidence: 96%

B‐type natriuretic peptide predicts stroke of presumable cardioembolic origin in addition to coronary artery calcification

Kara

Gronewold

Neumann

et al. 2014

Euro J of Neurology

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“…In some guidelines, these two biomarkers have an equal role in the diagnostic evaluation of heart failure, based on the results of several comparisons of the two biomarkers’ utility for the diagnosis or exclusion of acute heart failure [14, 16, 18]. Both the BNP and NT-proBNP levels at less than a cutoff point for the diagnosis of heart failure have also provided prognostic power for cardiovascular outcomes in general and hypertensive populations [3-5]. …”

Section: Discussionmentioning

confidence: 99%

“…Both BNP and NT-proBNP have also been reported to be prognostic markers in not only heart failure populations but also general or hypertensive populations [3-5]. In some studies performing a head-to-head comparison of the diagnostic utility of BNP and NT-proBNP for the screening of left ventricular function and the prognostic power of cardiovascular prognosis, the utility of the two biomarkers was largely similar [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Correlation between B-Type Natriuretic Peptide and N-Terminal pro-B-Type Natriuretic Peptide in a Large Japanese Population at Risk of Stage A Heart Failure

Taki

Hoshide

Kono

et al. 2018

Pulse

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Background: The measurements of B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are useful for ruling out heart failure and as prognostic markers in not only heart failure populations but also general populations. It is not clear whether these two biomarkers are elevated in parallel or associated with demographic characteristics in large populations at risk of stage A heart failure. Here we investigated the relationship between BNP and NT-proBNP and extended the evaluation of this association to known demographic disparities in stage A heart failure. Methods: Of 4,310 ambulatory patients, we analyzed the cases of the 3,643 (mean age 65 ± 11 years, 46% male, and 79% on antihypertensive medication) patients whose serum BNP and NT-proBNP levels were both measured and who had a history of and/or risk factors for cardiovascular disease from the Japan Morning Surge-Home Blood Pressure (J-HOP) Study dataset. Results: The median (25th–75th percentiles) BNP and NT-proBNP values were 18.7 (9.3–38.5) pg/mL and 50.3 (25.5–97.4) pg/mL. There was a significant association between log-transformed BNP and log-transformed NT-proBNP (r = 818, p < 0.001). A multiple linear regression analysis showed that log-transformed NT-proBNP was significantly associated with log-transformed BNP (beta coefficient = 0.774, p < 0.001). When stratified by demographic characteristics, these associations remained (all p < 0.001). Conclusion: In a large Japanese population at risk of stage A heart failure, there was a significant association between BNP and NT-proBNP after adjustment and stratification by demographics.

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“…Since the National Integrated Project for Prospective Observation of non-communicable Disease and its Trends in the Aged 2010 (NIPPON DATA2010) cohort is currently in the process of investigating participant prognosis, we aimed to demonstrate the correlation between PTFV1 and B-type natriuretic peptide (BNP) concentration in a contemporary representative Japanese population; the latter is a known biomarker of left ventricular dysfunction and has also been reported to be associated with incident AF, stroke, and other major CVDs in both Western and Asian populations [9][10][11][12][13][14] . This is the first study to investigate the correlation between these two biological markers.…”

Section: Aimmentioning

confidence: 99%

Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010

Shoji¹,

Kohsaka²,

Sawano³

et al. 2021

JAT

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Aims: P-wave terminal force in lead V1 (PTFV1) is an electrocardiogram marker of increased left atrial pressure and may be a noninvasive and early detectable marker for future cardiovascular events in the general population compared to serum B-type natriuretic peptide (BNP) concentration. The clinical significance of PTFV1 in the contemporary general population is an area of unmet need. We aimed to demonstrate the correlation between PTFV1 and BNP concentrations in a contemporary representative Japanese population.Methods: Among 2,898 adult men and women from 300 randomly selected districts throughout Japan (NIP-PON DATA2010), we analyzed 2,556 participants without cardiovascular disease (stroke, myocardial infarction, and atrial fibrillation). Elevated BNP was defined as a value of ≥ 20 pg/mL based on the definition from the Japanese Circulation Society guidelines. Results:In total, 125 (4.9%) participants had PTFV1. Participants with PTFV1 were older with a higher prevalence of hypertension, major electrocardiographic findings, and elevated BNP concentrations (13.5 [6.9, 22.8] versus 7.8 [4.4, 14.5] pg/mL; P 0.001). After adjustment for confounders, PTFV1 was correlated with elevated BNP (odds ratio, 1.66; 95% confidence interval, 1.05-2.62; P 0.030). This correlation was consistent among various subgroups and was particularly evident in those aged 65 years or those without a history of hypertension. Conclusions:In the contemporary general population cohort, PTFV1 was independently related to high BNP concentration. PTFV1 may be an alternative marker to BNP in identifying individuals at a higher risk of future cardiovascular events in the East Asian population. cause of death worldwide in both men and women 1) . There is considerable evidence that the onset of CVD may be delayed or prevented through interventions

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Sex-Specific Threshold Levels of Plasma B-Type Natriuretic Peptide for Prediction of Cardiovascular Event Risk in a Japanese Population Initially Free of Cardiovascular Disease

Cited by 12 publications

References 17 publications

B‐type natriuretic peptide predicts stroke of presumable cardioembolic origin in addition to coronary artery calcification

B‐type natriuretic peptide predicts stroke of presumable cardioembolic origin in addition to coronary artery calcification

Correlation between B-Type Natriuretic Peptide and N-Terminal pro-B-Type Natriuretic Peptide in a Large Japanese Population at Risk of Stage A Heart Failure

Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010

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