B‐type natriuretic peptide predicts stroke of presumable cardioembolic origin in addition to coronary artery calcification

Kara, Kaffer; Gronewold, Janine; Neumann, Till; Mahabadi, Amir A.; Weimar, Christian; Lehmann, Nils; Berger, Klaus; Kälsch, Hagen; Bauer, Marcus; Broecker-Preuß, Martina; Möhlenkamp, Stefan; Moebus, Susanne; Jöckel, Karl‐Heinz; Erbel, Raimund

doi:10.1111/ene.12411

Cited by 22 publications

(17 citation statements)

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“…Moreover, BNP is increased in subjects with early stages of cardiac diseases such as diastolic dysfunction and left ventricular hypertrophy which also are associated with AF [7,8]. In population-based studies, BNP predicted major cardiovascular outcomes in subjects without known cardiac diseases [9,10]. However, data on the ability of BNP to predict future AF based on general population cohorts are limited.…”

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confidence: 99%

B-type natriuretic peptide for incident atrial fibrillation—The Heinz Nixdorf Recall Study

Kara

Geisel

Möhlenkamp

et al. 2015

Journal of Cardiology

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confidence: 99%

B-type natriuretic peptide for incident atrial fibrillation—The Heinz Nixdorf Recall Study

Kara

Geisel

Möhlenkamp

et al. 2015

Journal of Cardiology

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“…Different applications have been assigned to N‐terminal section brain natriuretic peptide (NT‐proBNP) in several studies, and an acceptable diagnostic value in distinguishing ischemic stroke from other subtypes (Hajsadeghi et al, ) also predicts presumable cardioembolic stroke independent of coronary calcification (Kara et al, ; Yang et al, ). Moreover, it is a significant predictor of major adverse cardiovascular events in stable coronary disease, as well as a strong predictor of death and a wide range of cardiovascular events (Linssen et al, ; Mishra et al, ) and some non‐cardiovascular causes (Oluleye et al, ).…”

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confidence: 99%

Association of cardiovascular emerging risk factors with acute coronary syndrome and stroke: A case‐control study

Linares

Barrilao

Peinado

et al. 2016

Nursing & Health Sciences

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In this study, we estimated the risk of acute coronary syndrome and stroke associated with several emerging cardiovascular risk factors. This was a case-control study, where an age - and sex-matched acute coronary syndrome group and stroke group were compared with controls. Demographic and clinical data were collected through patient interviews, and blood samples were taken for analysis. In the bivariate analysis, all cardiovascular risk factors analyzed showed as predictors of acute coronary syndrome and stroke, except total cholesterol and smoking. In the multivariate logistic regression model for acute coronary syndrome, hypertension and body mass index, N-terminal section brain natriuretic peptide and pregnancy-associated plasma protein-A were independent predictors. For stroke, the predictors were hypertension, diabetes mellitus, body mass index, and N-terminal section brain natriuretic peptide. Controlling for age, sex, and classical cardiovascular risk factors, N-terminal section brain natriuretic peptide and pregnancy-associated plasma protein-A were independent emerging cardiovascular risk factors for acute coronary syndrome, but pregnancy-associated plasma protein-A was not for stroke. High levels of cardiovascular risk factors in individuals with no episodes of cardiovascular disease requires the implementation of prevention programs, given that at least half of them are modifiable.

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“…According to Kara et al, 3 BNP predicted stroke in men but not in women, both in subjects under and over 65 years of age. In another study by Duschek et al, 4 the authors assessed NT-proBNP in both men and women with asymptomatic high-grade carotid stenosis, and concluded that male patients ≥75 years with low levels of NT-proBNP had the same survival rate as younger patients, making them eligible for carotid endarterectomy.…”

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confidence: 97%

Letter by Galyfos et al Regarding Article, “N-Terminal Pro-B-Type Natriuretic Peptide and Stroke Risk: The Reasons for Geographic and Racial Differences in Stroke Cohort”

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B‐type natriuretic peptide predicts stroke of presumable cardioembolic origin in addition to coronary artery calcification

Abstract: BNP predicts presumable cardioembolic stroke independent of coronary calcification.

Cited by 22 publications

References 30 publications

B-type natriuretic peptide for incident atrial fibrillation—The Heinz Nixdorf Recall Study

B-type natriuretic peptide for incident atrial fibrillation—The Heinz Nixdorf Recall Study

Association of cardiovascular emerging risk factors with acute coronary syndrome and stroke: A case‐control study

Letter by Galyfos et al Regarding Article, “N-Terminal Pro-B-Type Natriuretic Peptide and Stroke Risk: The Reasons for Geographic and Racial Differences in Stroke Cohort”

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