Sex hormone measurements using mass spectrometry and sensitive extraction radioimmunoassay and risk of estrogen receptor negative and positive breast cancer: Case control study in UK Collaborative Cancer Trial of Ovarian Cancer Screening (UKCTOCS)

Fourkala, Evangelia‐Ourania; Blyuss, Oleg; Field, H P; Gunu, Richard; Ryan, Andy; Barth, Julian H.; Jacobs, Ian; Zaikin, Alexey; Dawnay, Anne; Menon, Usha

doi:10.1016/j.steroids.2016.04.003

Cited by 17 publications

(6 citation statements)

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“…Because the activation of ERb by a highly selective agonist led to inhibition of SKOV-3 OC cells [98], it would be an interesting approach to target the ERa/ERb balance in ER-positive subtypes of OC so that patients could take the advantage of an association of ERa antagonists, ERb agonists, and even aromatase inhibitors to increase their chances of an effective treatment response. Despite the remarkable progress in the treatment of breast cancer (BC) over the past decades, this disease is still one of the most leading causes of death among women [99], and is certainly a public health issue accounting for 25% of all cancers in females worldwide [100]. Although the mortality rates are falling in most European countries, as well as in South and North America [101], the American Cancer Society estimated 246,660 new cases of invasive and 61,000 in situ BC in 2016.…”

Section: Endocrine Therapy For Ocmentioning

confidence: 99%

The role of sex hormones and steroid receptors on female reproductive cancers

et al. 2017

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Sex steroids have been widely described to be associated with a number of human diseases, including hormone-dependent tumors. Several studies have been concerned about the factors regulating the availability of sex steroids and its importance in the pathophysiological aspects of the reproductive cancers in women. In premenopausal women, large fluctuations in the concentration of circulating estradiol (E2) and progesterone (P4) orchestrate many events across the menstrual cycle. After menopause, the levels of circulating E2 and P4 decline but remain at high concentration in the peripheral tissues. Notably, there is a strong relationship between circulating sex hormones and female reproductive cancers (e.g. ovarian, breast, and endometrial cancers). These hormones activate a number of specific signaling pathways after binding either to estrogen receptors (ERs), especially ERα, ERα36, and ERβ or progesterone receptors (PRs). Importantly, the course of the disease will depend on particular transactivation pathway. Identifying ER- or PR-positive tumors will benefit patients in terms of proper endocrine therapy. Based on hormonal responsiveness, effective prevention methods for ovarian, breast, and endometrial cancers represent a special opportunity for women at risk of malignancies. Hormone replacement therapy (HRT) might significantly increase the risk of these cancer types, and endocrine treatments targeting ER signaling may be helpful against E2-dependent tumors. This review will present the role of sex steroids and their receptors associated with the risk of developing female reproductive cancers, with emphasis on E2 levels in pre and postmenopausal women. In addition, new therapeutic strategies for improving the survival rate outcomes in women will be addressed.

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Section: Endocrine Therapy For Ocmentioning

confidence: 99%

The role of sex hormones and steroid receptors on female reproductive cancers

et al. 2017

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“…Only after adjustment for age, higher oestradiol levels may be associated with an increased risk of BC in women just before the age of 50 years 13 . In postmenopausal women, higher oestradiol and testosterone levels increase the risk of BC (OR 2.34) irrespective of oestrogen receptor positivity 14 .…”

Section: Reproduction-related Factorsmentioning

confidence: 99%

Risks and protective factors for triple negative breast cancer with a focus on micronutrients and infections

et al. 2018

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Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out. We also found statistical information from current online databases concerning the estimated incidence, prevalence and mortality worldwide of this cancer. Traditional risk factors for BC and TNBC are those related to reproduction such as the age of menarche, age of first birth, parity, breastfeeding and age at menopause. Attention needs to be paid to familial BC, weight control, alcohol consumption and regular physical activity. Epidemiological studies on TNBC provide evidence for protective factors such as regular consumption of soya, seafood, green tea, folic acid and vitamin D. Potential risk factors may include night work and viral infectious agents like human papillomavirus (HPV) and Epstein-Barr virus (EBV). Droplet digital methylation-specific PCR (ddMSP) is a possible new screening method for detection of BC including TNBC. Further research is necessary to validate these new factors.

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“…Biosensors are chemical sensors that utilise biochemical mechanisms in their recognition system. The IUPAC defines chemical sensors as devices that transform chemical information, ranging from the concentration of a specific sample component to total composition analysis, into an analytically useful signal [5,11].…”

Section: Typementioning

confidence: 99%

“…The theory describes the scattering features of prolate and oblate spheroid nanoparticles. Based on this, the absorption cross-section for a prolate spheroid is described by Equation (11) [55].…”

Section: 𝜀 (𝜆) (𝜀 (𝜆) + 2𝜀 ) + 𝜀 (𝜆)mentioning

confidence: 99%

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Plasmonic Biosensors for the Detection of Lung Cancer Biomarkers: A Review

et al. 2021

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Lung cancer is the most common and deadliest cancer type globally. Its early diagnosis can guarantee a five-year survival rate. Unfortunately, application of the available diagnosis methods such as computed tomography, chest radiograph, magnetic resonance imaging (MRI), ultrasound, low-dose CT scan, bone scans, positron emission tomography (PET), and biopsy is hindered due to one or more problems, such as phenotypic properties of tumours that prevent early detection, invasiveness, expensiveness, and time consumption. Detection of lung cancer biomarkers using a biosensor is reported to solve the problems. Among biosensors, optical biosensors attract greater attention due to being ultra-sensitive, free from electromagnetic interference, capable of wide dynamic range detection, free from the requirement of a reference electrode, free from electrical hazards, highly stable, capable of multiplexing detection, and having the potential for more information content than electrical transducers. Inspired by promising features of plasmonic sensors, including surface plasmon resonance (SPR), localised surface plasmon resonance (LSPR), and surface enhanced Raman scattering (SERS) such as ultra-sensitivity, single particle/molecular level detection capability, multiplexing capability, photostability, real-time measurement, label-free measurement, room temperature operation, naked-eye readability, and the ease of miniaturisation without sophisticated sensor chip fabrication and instrumentation, numerous plasmonic sensors for the detection of lung cancer biomarkers have been investigated. In this review, the principle plasmonic sensor is explained. In addition, novel strategies and modifications adopted for the detection of lung cancer biomarkers such as miRNA, carcinoembryonic antigen (CEA), cytokeratins, and volatile organic compounds (VOCs) using plasmonic sensors are also reported. Furthermore, the challenges and prospects of the plasmonic biosensors for the detection of lung cancer biomarkers are highlighted.

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Sex hormone measurements using mass spectrometry and sensitive extraction radioimmunoassay and risk of estrogen receptor negative and positive breast cancer: Case control study in UK Collaborative Cancer Trial of Ovarian Cancer Screening (UKCTOCS)

Abstract: Abstract:Introduction: Associations of endogenous sex hormone levels and all as well as estrogen-receptor

Cited by 17 publications

References 30 publications

The role of sex hormones and steroid receptors on female reproductive cancers

The role of sex hormones and steroid receptors on female reproductive cancers

Risks and protective factors for triple negative breast cancer with a focus on micronutrients and infections

Plasmonic Biosensors for the Detection of Lung Cancer Biomarkers: A Review

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