Sex Differences in Animal Models: Focus on Addiction

Becker, Jill B.; Koob, George F.

doi:10.1124/pr.115.011163

Cited by 597 publications

(513 citation statements)

References 217 publications

Supporting

Mentioning

446

Contrasting

Order By: Relevance

“…Sex differences have also been observed in a human genetic study, showing that the Pomc two-marker haplotype is associated with alcoholism only in women [Racz et al, 2008]. These results also contribute to the idea that there are sex differences in opioid regulation of alcohol dependence [Becker and Koob, 2016].…”

Section: Pro-opiomelanocortin (Pomc)/β-endorphin and Mu-opioid Resupporting

confidence: 63%

“…These findings provide support for the critical involvement of the KOP-r/dynorphin system in the process of alcohol addiction, though the literature is not consistent. There are sex differences in dynorphin/KOP-r systems [Chartoff and Mavrikaki, 2015] and alcohol drinking behavior [Becker and Koob, 2016]. Indeed, we observe a reduction of alcohol drinking with the selective KOP-r antagonist nor-binaltorphimine (nor-BNI, slow onset and extraordinarily long-lasting effect [Horan et al, 1992]) in male mice, while the same nor-BNI treatment has no effect on alcohol drinking in female mice [Zhou et al, 2017a].…”

Section: Kappa Opioid Receptor (Kop-r) and Dynorphin Systemmentioning

confidence: 71%

See 1 more Smart Citation

Involvement of Activated Brain Stress Responsive Systems in Excessive and “Relapse” Alcohol Drinking in Rodent Models: Implications for Therapeutics

Zhou

Kreek

2018

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Addiction to specific drugs (such as alcohol, psychostimulants and opioids) shares some common direct or downstream effects on the brain stress-responsive systems, including arginine vasopressin and its V1b receptors, dynorphin and the kappa opioid receptors, proopiomelanocortin/β-endorphin and the mu opioid receptors, and the endocannabinoids. Further study of these systems, through laboratory-based and translational research, could lead to the discovery of novel treatment targets and the early optimization of interventions (for example, combination) for the pharmacological therapy of alcoholism.

show abstract

Section: Pro-opiomelanocortin (Pomc)/β-endorphin and Mu-opioid Resupporting

confidence: 63%

Section: Kappa Opioid Receptor (Kop-r) and Dynorphin Systemmentioning

confidence: 71%

Involvement of Activated Brain Stress Responsive Systems in Excessive and “Relapse” Alcohol Drinking in Rodent Models: Implications for Therapeutics

Zhou

Kreek

2018

J Pharmacol Exp Ther

View full text Add to dashboard Cite

show abstract

“…In addition, there is great potential to gain mechanistic insight from studies where sex differences are identified. The antiquated myth that females are 'messy' and make research more difficult is not supported by the evidence, and articles such as this one, and those from other investigators who have been considering sex and gender in their research for decades, will help promote the inclusion and importance of SABV in biomedical research (Bale and Epperson, 2015;Miller et al, 2015;Becker and Koob, 2016;Joel and McCarthy, 2016).…”

Section: Resultsmentioning

confidence: 99%

Sex as a Biological Variable: Who, What, When, Why, and How

Bale

Epperson

2016

Neuropsychopharmacol

119

View full text Add to dashboard Cite

The inclusion of sex as a biological variable in research is absolutely essential for improving our understanding of disease mechanisms contributing to risk and resilience. Studies focusing on examining sex differences have demonstrated across many levels of analyses and stages of brain development and maturation that males and females can differ significantly. This review will discuss examples of animal models and clinical studies to provide guidance and reference for the inclusion of sex as an important biological variable relevant to a Neuropsychopharmacology audience.

show abstract

“…Housing conditions may differentially affect behavior in males and females (Becker and Koob, 2016). Females are more social and males are more territorial.…”

Section: Discussionmentioning

confidence: 99%

Sex, strain, and estrous cycle influences on alcohol drinking in rats

Priddy

Carmack

Thomas

et al. 2017

Pharmacology Biochemistry and Behavior

Self Cite

179

125

View full text Add to dashboard Cite

Although women appear to be more vulnerable to alcohol-induced pathophysiology than men, the neurobiological basis for sex differences is largely unknown, partially because most studies on alcohol drinking are conducted in male subjects only. The present study examined sex differences in alcohol consumption in two rat strains, Long Evans and Wistar, using multiple behavioral paradigms. The effects of the estrous cycle on alcohol consumption were monitored throughout the study. The results indicated that females drank more alcohol than males when given either continuous or intermittent access to alcohol (vs. water) in their home cages (voluntary drinking). Under operant conditions, no sex or strain differences were found in drinking prior to development of alcohol dependence. However, upon dependence induction by chronic, intermittent alcohol vapor exposure, Wistar rats of both sexes substantially escalated their alcohol intake compared with their nondependent drinking levels, whereas Long Evans rats only exhibited a moderate escalation of drinking. Under these conditions, the estrous cycle had no effect on alcohol drinking in any strain and drinking model. Thus, strain, sex, and drinking conditions interact to modulate nondependent and dependent alcohol drinking. The present results emphasize the importance of including sex and strain as biological variables in exploring individual differences in alcohol drinking and dependence.

show abstract

Sex Differences in Animal Models: Focus on Addiction

Cited by 597 publications

References 217 publications

Involvement of Activated Brain Stress Responsive Systems in Excessive and “Relapse” Alcohol Drinking in Rodent Models: Implications for Therapeutics

Involvement of Activated Brain Stress Responsive Systems in Excessive and “Relapse” Alcohol Drinking in Rodent Models: Implications for Therapeutics

Sex as a Biological Variable: Who, What, When, Why, and How

Sex, strain, and estrous cycle influences on alcohol drinking in rats

Contact Info

Product

Resources

About