Sex Differences in Alcohol Drinking Patterns During Forced and Voluntary Consumption in Rats

Juárez, José Antonio Caballero; Tomasi, Eliana Barrios De

doi:10.1016/s0741-8329(99)00010-5

Cited by 105 publications

(65 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are also consistent with previous reports of female versus male ethanol consumption during long-access sessions (Adams, 1995;Almeida et al, 1998;Juarez and de Tomasi, 1999;Lancaster et al, 1996;Lancaster and Spiegel, 1992). The increased consumption of ethanol observed in the present study could be attributable to sex differences in the rate of ethanol elimination.…”

Section: Discussionsupporting

confidence: 94%

Dissociable effects of ethanol consumption during the light and dark phase in adolescent and adult Wistar rats

Walker¹,

Walker²,

Ehlers³

2008

Alcohol

View full text Add to dashboard Cite

In adolescence, high levels of drinking over short episodes (binge drinking) is commonly seen in a proportion of the population. Since adolescence is an important neurodevelopmental period, the effects of binge drinking on brain and behavior has become a significant health concern. However, robust animal models of binge drinking in rats are still being developed and therefore further efforts are needed to optimize paradigms for inducing maximal self-administration of alcohol. In the present experiment, one-hour limited-access self-administration sessions were instituted to model excessive drinking behavior in adolescent and adult Wistar rats. In addition to age, the involvement of sex and phase within the light/dark cycle (i.e., drinking in the light or dark) on sweetened 5% ethanol intake were also evaluated over fourteen limited-access sessions using a between-groups design. The results of the experiment showed that over fourteen limited-access sessions, sweetened ethanol intake (g/ kg) was significantly higher for adolescents compared to adults. Females were also found to drink more sweetened ethanol as compared to males. Additionally, drinking in the light produced a robust increase in sweetened ethanol intake (g/kg) in adolescents, as compared to adults during the light phase and as compared to both adolescent and adult rats drinking in the dark. Furthermore, the increase in ethanol consumption observed in adolescents drinking during the light phase was dissociable from sweetened solution intake patterns. These results identify that age, sex, and time of day all significantly influence consumption of sweetened ethanol in Wistar rats. Knowledge of these parameters should be useful for future experiments attempting to evaluate the effects of selfadministered ethanol exposure in adult and adolescent rats.

show abstract

Section: Discussionsupporting

confidence: 94%

Dissociable effects of ethanol consumption during the light and dark phase in adolescent and adult Wistar rats

Walker¹,

Walker²,

Ehlers³

2008

Alcohol

View full text Add to dashboard Cite

show abstract

“…Male cynomolgus monkeys that are given limited access and unlimited access to alcohol drink more than females and attain higher blood alcohol levels (Vivian et al, 2001). However, female rodents drink more than males (Eriksson and Pikkarainen, 1968;Hutchins et al, 1981;Li and Lumeng, 1984;Lancaster and Spiegel, 1992;Lancaster et al, 1996;Almeida et al, 1998;Juárez and Barrios de Tomasi, 1999;Blanchard et al, 1993;Walker et al, 2008;Maldonado-Devincci et al, 2010;Gamsby et al, 2013).…”

Section: Sex Differences In Drug Abusementioning

confidence: 99%

Sex Differences in Animal Models: Focus on Addiction

2016

View full text Add to dashboard Cite

“…Results obtained for alcohol suggest that patterns of intake for male and female animals vary between different species. For example, results from studies in rats and vervet monkeys on total alcohol intake revealed that females self-administer greater levels of alcohol compared to males (Lancaster and Spiegel 1992;Juarez et al 1993;Almeida et al 1998;Juarez and Barrios de Tomasi 1999). In contrast, studies comparing male and female rhesus monkeys reveal that females are less likely than males to maintain consumption (Grant and Johanson 1988), but they self-administer similar levels of alcohol across a wide range of concentrations (Pakarinen et al 1999;Vivian et al 1999).…”

Section: Preclinical Reports Of Sex Differencesmentioning

confidence: 99%

Biological basis of sex differences in drug abuse: preclinical and clinical studies

2002

View full text Add to dashboard Cite

The recent focus on drug abuse in women has brought attention to numerous differences between women and men. In this review, we discuss both preclinical and clinical findings of sex differences in drug abuse as well as mechanisms that may underlie these differences. Recent evidence suggests that the progression to dependence and abuse may differ between women and men; thus, different prevention and treatment strategies may be required. Similar sex differences in drug sensitivity and self-administration have been reported in laboratory animal studies. Females appear to be more vulnerable than males to the reinforcing effects of psychostimulants, opiates, and nicotine during many phases of the addiction process (e.g. acquisition, maintenance, dysregulation-escalation, relapse). Male and female animals differ in their behavioral, neurological, and pharmacological responses to drugs. Although the role of sex in the mechanisms of drug action remains unclear, preclinical and clinical studies indicate that ovarian hormones, particularly estrogen, play a role in producing sex differences in drug abuse. Future research is necessary to provide information on how to design more effective drug abuse treatment programs and resources that are sex specific.

show abstract

Sex Differences in Alcohol Drinking Patterns During Forced and Voluntary Consumption in Rats

Cited by 105 publications

References 25 publications

Dissociable effects of ethanol consumption during the light and dark phase in adolescent and adult Wistar rats

Dissociable effects of ethanol consumption during the light and dark phase in adolescent and adult Wistar rats

Sex Differences in Animal Models: Focus on Addiction

Biological basis of sex differences in drug abuse: preclinical and clinical studies

Contact Info

Product

Resources

About