Sex Difference in Neutrophils

Tenczar, Francis J.; Streitmatter, David E.

doi:10.1093/ajcp/26.4.384

Cited by 12 publications

(2 citation statements)

References 5 publications

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“…This observation militates against the possibility that the sex chromatin appendage may be a difference in the manifestation of diseases among males and females and strengthens the thesis of genetic origin [11].…”

Section: Genetical Pointmentioning

confidence: 86%

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Sex Chromatin in Peripheral Blood Neutrophils and Sex Determination

Miknienė¹,

Ivanauskaitė²

2018

CRCM

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The objective of this paper is to review in what forms sex chromatin can appear in peripheral blood neutrophils and how sex determination can be done using sex chromatin appendages. Sex chromatin is an approximately 1 micron clump of chromatin seen usually at the periphery of female nuclei in certain tissues and called "Barr body" and as a drumstick in polymor phonuclear neutrophils nuclei in the blood smears. Sex chromatin is derived from one of the two X chromosomes in the female which replicates its deoxyribonucleic acid much later than the other and is thus positively heteropyknotic. In 1954, Davidson and Smith were the first to identify and report the presence of neutrophil drumsticks and nonspecific appendages and their differences in sexes. The inactive X chromosome in neutrophils appears in one of the five forms: drumsticks, racquet forms, sessile nodules, small clubs and minor lobes. Only drumstick appendage is sex-specific and considered for sex diagnosis. For sex determination, drumsticks are significantly higher in females than in males (p < 0.001).

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Section: Genetical Pointmentioning

confidence: 86%

“…A drumstick consists of a small nuclear mass of about 1.5 μ in diameter, attached to the body of the nucleus by means of a thin stalk [ [11]. Some of these drumsticks are hidden or partly hidden by one of the lobes of the nucleus, but must be counted only those which are discrete [7].…”

Section: Drumsticksmentioning

confidence: 99%