Sex-Based Differences in the Tumor Microenvironment

Wuidar, Vincent; Gillot, Lionel; Silva, Isabelle Dias Da; Lebeau, Alizée; Gallez, Anne; Péqueux, Christel

doi:10.1007/978-3-030-73119-9_23

Cited by 4 publications

(2 citation statements)

References 260 publications

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“… 51 This highlights the need for studies focusing on the impact of biological sex on cancer initiation, progression, and therapy response. 53 …”

Section: Discussionmentioning

confidence: 99%

Single-cell profiling of murine bladder cancer identifies sex-specific transcriptional signatures with prognostic relevance

Abdel-Hafiz,

Kailasam Mani,

Huang

et al. 2023

iScience

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“… 51 This highlights the need for studies focusing on the impact of biological sex on cancer initiation, progression, and therapy response. 53 …”

Section: Discussionmentioning

confidence: 99%

Single-cell profiling of murine bladder cancer identifies sex-specific transcriptional signatures with prognostic relevance

Abdel-Hafiz,

Kailasam Mani,

Huang

et al. 2023

iScience

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“…In general, males exhibit a higher incidence and poorer outcomes compared to females across these cancers. Sex hormones and sex chromosomes, including the loss of the Y chromosome 3,4 , are the main factors driving tumor-intrinsic 5 or tumorextrinsic 6 sex differences in cancers. Recently, a crucial role for androgens in anti-tumor immunity and their impact on immune checkpoint inhibitor treatment have been identified.…”

Section: Introductionmentioning

confidence: 99%

Androgen loss weakens anti-tumor immunity and accelerates brain tumor growth

Lathia,

Lee,

Chung

et al. 2024

Preprint

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Many cancers, including glioblastoma (GBM), have a male-biased sex difference in incidence and outcome. The underlying reasons for this sex bias are unclear but likely involve differences in tumor cell state and immune response. This effect is further amplified by sex hormones, including androgens, which have been shown to inhibit anti-tumor T cell immunity. Here, we show that androgens drive anti-tumor immunity in brain tumors, in contrast to its effect in other tumor types. Upon castration, tumor growth was accelerated with attenuated T cell function in GBM and brain tumor models, but the opposite was observed when tumors were located outside the brain. Activity of the hypothalamus-pituitary-adrenal gland (HPA) axis was increased in castrated mice, particularly in those with brain tumors. Blockade of glucocorticoid receptors reversed the accelerated tumor growth in castrated mice, indicating that the effect of castration was mediated by elevated glucocorticoid signaling. Furthermore, this mechanism was not GBM specific, but brain specific, as hyperactivation of the HPA axis was observed with intracranial implantation of non-GBM tumors in the brain. Together, our findings establish that brain tumors drive distinct endocrine-mediated mechanisms in the androgen-deprived setting and highlight the importance of organ-specific effects on anti-tumor immunity.

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Sex differences in the diagnosis, treatment and prognosis of cancer: the rationale for an individualised approach

et al. 2023

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Background Precision medicine in oncology aims to identify the most beneficial interventions based on a patient’s individual features and disease. However, disparities exist when providing cancer care to patients based on an individual’s sex. Objective To discuss how sex differences impact the epidemiology, pathophysiology, clinical manifestations, disease progression, and response to treatment, with a focus on data from Spain. Results Genetic and environmental factors (social or economic inequalities, power imbalances, and discrimination) that contribute to these differences adversely affect cancer patient health outcomes. Increased health professional awareness of sex differences is essential to the success of translational research and clinical oncological care. Conclusions The Sociedad Española de Oncología Médica created a Task Force group to raise oncologists’ awareness and to implement measures to address sex differences in cancer patient management in Spain. This is a necessary and fundamental step towards optimizing precision medicine that will benefit all individuals equally and equitably.

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Sex-Based Differences in the Tumor Microenvironment

Cited by 4 publications

References 260 publications

Single-cell profiling of murine bladder cancer identifies sex-specific transcriptional signatures with prognostic relevance

Single-cell profiling of murine bladder cancer identifies sex-specific transcriptional signatures with prognostic relevance

Androgen loss weakens anti-tumor immunity and accelerates brain tumor growth

Sex differences in the diagnosis, treatment and prognosis of cancer: the rationale for an individualised approach

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