Single-cell profiling of murine bladder cancer identifies sex-specific transcriptional signatures with prognostic relevance

Abdel-Hafiz, Hany A.; Kailasam Mani, Saravana Kumar; Huang, Wesley; Gouin, Kenneth H.; Chang, Yuzhou; Xiao, Tong; Ma, Qin; Li, Zihai; Knott, Simon R.V.; Theodorescu, Dan

doi:10.1016/j.isci.2023.107703

Cited by 3 publications

(4 citation statements)

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“…We next focused on one cancer site that is known to affect both males and females differently 35 – 38 , where YBX1 expression was not identified to significantly affect survival in our analysis: bladder cancer. We generated correlation coefficients for the expression of YBX1 and individual X-linked genes in both male and female patients.…”

Section: Resultsmentioning

confidence: 99%

“…The regulation of these critical processes is increasingly linked to biological sex. This fundamental biological variable is defined by the presence of genetic information provided by the X and Y chromosomes, whose regulation and loss are proving relevant to cancer biology and treatment outcomes 7 – 9 , 36 , 38 , 45 – 47 . Lack of sex analysis in preclinical and interventional studies was proposed to increase the risk for an effect being lost or claimed where it only applies to one sex 16 .…”

Section: Discussionmentioning

confidence: 99%

“…In both male and female patients with bladder cancer, we identified 37 interactions common to both sexes, 10 limited to male patients and 78 to female patients. The relevance of biological sex in this disease is increasingly reported and could affect disease classification, and immune responses 36 , 38 , 47 . Further characterisation of the relevance of X-linked genes to the behaviour of malignant diseases is warranted.…”

Section: Discussionmentioning

confidence: 99%

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In silico analysis of overall survival with YBX1 in male and female solid tumours

Grimes,

Rassamegevanon,

Marignol

2024

Sci Rep

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The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology. Disparities in treatment outcomes between male and female cancer patients are increasingly reported. This study aimed to examine the relationship between YBX1 expression and overall survival in male and female patients with solid tumours. Overall survival and YBX1 expression data for cohorts of male and female cancer patients obtained from freely available databases were analysed with a cox proportional hazard model with covariates of biological sex and YBX1 expression. Kaplan–Meier curves and Violin plots were constructed for segregated male and female cohorts. High YBX1 expression was significantly associated with poor survival in 2 female-only and 4 mixed-sex cancer sites. In female lung cancer patients, better survival and lower YBX1 expression were identified. The clinical importance of YBX1 expression in cancer ought to be evaluated in a sex-specific manner, especially in lung cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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In silico analysis of overall survival with YBX1 in male and female solid tumours

Grimes,

Rassamegevanon,

Marignol

2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Modification of the ECM texture represents one of the events responsible for setting the neoplastic background also in primary bladder cancer, as proposed to explain the metastatic spread of the disease [25] , [26] , [27] . Sex-specific differences for BCa have been explained by differences in the urothelial TME, for instance in the local microbiome [28] and immune infiltration [29] . As a consequence, also the extent of the modification of the ECM topography must be investigated in male and female bladder cancer patients, which was not possible in this study due to the limited number of female patients.…”

Section: Discussionmentioning

confidence: 99%