Sevoflurane-emergence agitation: effect of supplementary low-dose oral ketamine premedication in preschool children undergoing dental surgery

Khattab, A. S.; Elseify, Zeinab Ahmed; Shaaban, Ashraf; Radojevic, Dobrila; Jankovic, Ivanka

doi:10.1097/eja.0b013e328335b2ec

Cited by 21 publications

(4 citation statements)

References 32 publications

(44 reference statements)

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“…The median time from publication to retraction was 31 months (mean 39 mo, range 1–130 mo). Most of the retracted articles were clinical trials (81 articles [79%]) . The remainder consisted of reviews (12 [12%]), retrospective studies (5 [5%]), and case reports (4 [4%]) .…”

Section: Resultsmentioning

confidence: 99%

Retracted Publications in the Drug Literature

2012

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Recent studies have suggested an increase in the number of retracted scientific publications. It is unclear how broadly the issue of misleading and fraudulent publications pertains to retractions of drug therapy studies. Therefore, we sought to determine the trends and factors associated with retracted publications in drug therapy literature. A PubMed search was conducted to identify retracted drug therapy articles published from 2000-2011. Articles were grouped according to reason for retraction, which was classified as scientific misconduct or error. Scientific misconduct was further divided into data fabrication, data falsification, questions of data veracity, unethical author conduct, and plagiarism. Error was defined as duplicate publication, scientific mistake, journal error, or unstated reasons. Additional data were extracted from the retracted articles, including type of article, funding source, author information, therapeutic area, and retraction issue. A total of 742 retractions were identified from 2000-2011 in the general biomedical literature, and 102 drug studies met our inclusion criteria. Of these, 73 articles (72%) were retracted for a reason classified as scientific misconduct, whereas 29 articles (28%) were retracted for error. Among the 73 articles classified as scientific misconduct, those classified as unethical author conduct (32 articles [44%]) and data fabrication (24 articles [33%]) constituted the majority. The median time from publication of the original article to retraction was 31 months (range 1-130). Fifty percent of retracted articles did not state a funding source, whereas pharmaceutical manufacturer funding accounted for only 13 articles (13%) analyzed. Many retractions were due to repeat offenses by a small number of authors, with nearly 40% of the retracted studies associated with two individuals. We found that a greater proportion of drug therapy articles were retracted for reasons of misconduct and fraud compared with other biomedical studies. It is important for health care practitioners to monitor the literature for retractions so that recommendations for drug therapy and patient management may be modified accordingly.

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Section: Resultsmentioning

confidence: 99%

Retracted Publications in the Drug Literature

2012

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“…Ketamine was reported to have been used successfully to reduce the incidence of EA[ 7 8 9 10 11 ] Dalens et al . [ 7 ] reported that the IV administration of 0.25 mg/kg of ketamine or nalbuphine 0.1 mg/kg before discontinuing of sevoflurane anesthesia reduced incidence of EA in children aged 6 months to 8 years undergoing cerebral magnetic resonance imaging with no delay in awakening or discharge.…”

Section: Discussionmentioning

confidence: 99%

“…[ 6 ] Ketamine, a non-competitive N-methyl-D-aspartate receptor antagonist is an effective drug for sedation, analgesia and amnesia and the effect of ketamine on decreasing the incidence of EA was confirmed by many studies. [ 7 8 9 10 11 ]…”

Section: Introductionmentioning

confidence: 99%

The effect of ketamine versus fentanyl on the incidence of emergence agitation after sevoflurane anesthesia in pediatric patients undergoing tonsillectomy with or without adenoidectomy

Abdelhalim

Alarfaj

2013

Saudi J Anaesth

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Background:Emergence agitation (EA) has been documented as a common side-effect of sevoflurane anesthesia. This prospective, randomized, double-blind, placebo-controlled study was designed to compare the effects of ketamine versus fentanyl, administered 10 min before the end of surgery on the development of EA.Methods:A total of 120 children aged 3-7 years of American Society of Anesthesiologists I-II physical status were randomly assigned to one of three equal groups receiving either ketamine 0.5 mg/kg (Group K), fentanyl 1 μg/kg (Group F) or saline (Group C) at 10 min before the end of surgery. Post-operative EA was assessed with Aono's four point scale. Recovery times, the post-operative pain and adverse reactions were assessed.Results:There was no significant difference between the three groups regarding recovery and discharge times from post-anesthesia care unit. The incidence of EA was significantly low in Group K and Group F (15% and 17.5%, respectively) compared to the control group (42.5%), with no significant difference between Group K and Group F. There were no significant differences in Children's Hospital of Eastern Ontario Pain Scale between the three groups. The incidence of nausea or vomiting was significantly more in Group F compared to that in other two groups. However, no complications such as somnolence, oxygen desaturation or respiratory depression occurred during the study period and there were no episodes of hallucinations or bad dreams in the ketamine group.Conclusion:The intravenous administration of either ketamine 0.5 mg/kg or fentanyl 1 μg/kg before the end of surgery in sevoflurane-anesthetized children undergoing tonsillectomy with or without adenoidectomy reduces the incidence of post-operative agitation without delaying emergence.

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“…In some studies, the effect of ketamine on the prevention of EA in dental surgeries and tonsillectomy has been reported. [ 12 13 14 ] A number of studies have shown that the use of ketamine under general anesthesia reduces the incidence of EA in children, but the number of these studies in adults is limited. [ 15 ] Also, lidocaine reduces sore throat after surgery and thus reduces cough and restlessness.…”

Section: Introductionmentioning

confidence: 99%

Comparing the effect of ketamine and lidocaine on agitation and pain in rhinoplasty: A randomized clinical trial

Omidvar

Ebrahimi

Amini

et al. 2023

JCAS

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Background: Emergence agitation (EA) is an important clinical problem that occurs during the initial period of recovery from anesthesia. This study aimed to determine the effects of ketamine and lidocaine administered on agitation level, postoperative pain, and hemodynamic changes in adults after rhinoplasty. Materials and Methods: Totally 72 patients scheduled to undergo elective rhinoplasty were enrolled in this prospective study. Patients were randomly divided into three groups including control group ( n = 24), ketamine group ( n = 24), and lidocaine group ( n = 24). Twenty minutes before surgery completion, 1 ml saline was administered intravenously to the saline group, while 0.5 mg/kg ketamine or 1.5 mg/kg lidocaine was administered to two other groups. The emergence agitation level of the patients was evaluated using the Richmond Agitation–Sedation Scale just after extubation and in the post-anesthesia care unit (PACU). Postoperative pain was evaluated by Numerical Rating Scale that scored (from 0 to 10) every 10 min until the patients were discharged from PACU. Results: There was a significant difference between EA level between ketamine ( P = 0.049) and lidocaine ( P = 0.019) groups compared to the control group, and there was a significant difference between pain level between the ketamine ( P = 0.008) and lidocaine ( P = 0.035) groups compared the to control group, while there was no significant difference between the level of agitation ( P = 0.922) and level of pain ( P = 0.845) after extubation between the ketamine and lidocaine groups. Conclusion: Ketamine and lidocaine are highly effective in preventing EA and pain control. Further studies with a greater sample size and longer follow-up period are needed to confirm the current findings.

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Sevoflurane-emergence agitation: effect of supplementary low-dose oral ketamine premedication in preschool children undergoing dental surgery

Abstract: Adding a low dose of oral ketamine to midazolam-based oral premedication in preschool children undergoing dental surgery reduced emergence agitation without delaying hospital discharge.

Cited by 21 publications

References 32 publications

Retracted Publications in the Drug Literature

Retracted Publications in the Drug Literature

The effect of ketamine versus fentanyl on the incidence of emergence agitation after sevoflurane anesthesia in pediatric patients undergoing tonsillectomy with or without adenoidectomy

Comparing the effect of ketamine and lidocaine on agitation and pain in rhinoplasty: A randomized clinical trial

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