Severity of perinatal cerebral injury and developmental outcome: A dose-response relationship.

Raz, Sarah; Lauterbach, Mary D.; Hopkins, Tracy L.; Porter, Cynthia L.; Riggs, Webster; Sander, Christian

doi:10.1037/0894-4105.9.1.91

Cited by 10 publications

(11 citation statements)

References 45 publications

(65 reference statements)

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“…To illustrate the magnitude of these effects, Whitaker et al (1997) found that risks of psychiatric disorder in a sample of 6-year-olds with less than 2,000 g birth weight were increased fourfold by indications on cerebral ultrasound of parenchymal lesions, ventricular enlargement, or both. Sequelae also were reported in children with milder grades of IVH, although the evidence in this regard is less substantial and further study is needed to determine associations of degree of IVH with outcomes (Frisk & Whyte, 1994;Raz et al, 1995;Ross et al, 1992;Selzer, Lindgren, & Blackman, 1992).…”

Section: Predictors Of Outcomementioning

confidence: 80%

School-Age Consequences of Birth Weight Less Than 750 g: A Review and Update

Taylor¹,

Klein²,

Hack³

2000

Developmental Neuropsychology

154

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Recent advances in perinatal care have led to the survival of increasing numbers of children born at the lower limits of viability. Children with very low birth weight (LBW; less than 1,500 g, 3 lb 5 oz) have been studied extensively. Findings document poorer outcomes relative to normal birth weight term-born controls in neurologic and health status, cognitive-neuropsychological skills, school performance, academic achievement, and behavior. This report reviews current knowledge regarding LBW children, with special emphasis on outcomes for children with birth weight less than 750 g (1 lb 10 oz). Results from an ongoing longitudinal study suggest a gradient of sequelae, with poorer outcomes in less than 750 g birth weight children compared to both 750 g to 1,499 g birth weight children and term-born controls. Children with less than 750 g birth weight fail to catch up with their peers over time and may even be at risk for age-related increases in sequelae. Outcomes are highly variable but related to neonatal medical complications of prematurity and social risk factors. Further research is needed to understand the etiology and neuropathological basis of sequelae, the long-term developmental implications of LBW, and treatment needs.

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Section: Predictors Of Outcomementioning

confidence: 80%

School-Age Consequences of Birth Weight Less Than 750 g: A Review and Update

Taylor¹,

Klein²,

Hack³

2000

Developmental Neuropsychology

154

View full text Add to dashboard Cite

show abstract

“…Twelve children with partial testing data were removed from this sample: four with cerebral palsy, six with a variety of intracranial pathologies, one with intracranial hemorrhage (ICH) grade >2, and one with both cerebral palsy and intracranial hemorrhage grade >2. We excluded moderate or severe cerebral palsy and intracranial hemorrhage as such pathologies may involve distinct causal mechanisms (e.g., Truwit, Barkovich, Koch, & Ferriero, 1992) with independent effects on neuropsychological functioning (Hou et al, 2010; Raz et al, 1995) that may, in turn, confound the hypothesized statistical effects of head growth. Altogether, 264 cases (153 boys and 111 girls) were included, ∼20.6% of the relevant Neonatal Intensive Care Unit cohort.…”

Section: Methodsmentioning

confidence: 99%

Postnatal growth and neuropsychological performance in preterm-birth preschoolers.

Raz¹,

Newman²,

DeBastos³

et al. 2014

Neuropsychology

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Among postnatal anthropometric indices, preschool stature, rather than head circumference, remains a consistent correlate of preschool outcome in preterm children, highlighting the contribution of general physical development to neuropsychological performance. Further investigation of the underlying mechanisms likely involves exploration of complex relationships between postnatal nutrition, growth hormone levels, body and brain development, and neuropsychological functioning.

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“…Twelve children were removed from the sample: Three with cerebral palsy (CP), four with intracranial hemorrhage (ICH) grade >2 (a single untestable case also with autistic-like symptoms), three with both CP and ICH grade >2, one with right porencephaly, and one with hydrocephalus. We excluded moderate or severe CP and ICH as such pathologies may involve distinct causal mechanisms (e.g., Truwit, Barkovich, Koch, & Ferriero, 1992) with independent effects on neuropsychological functioning (e.g., Hou et al, 2010; Raz et al, 1995) that may, in turn, confound the hypothesized effects of IUGR. Altogether, 143 cases (69 boys and 74 girls) were included, approximately 25% of the relevant hospital cohort.…”

Section: Methodsmentioning

confidence: 99%

Intrauterine Growth and Neuropsychological Performance in Very Low Birth Weight Preschoolers

Raz

DeBastos

Newman

et al. 2012

J Int Neuropsychol Soc

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In this study we examined the association between intrauterine growth, indexed either as a categorical variable or continuous dimension, and neuropsychological outcome, in a very low birth weight (VLBW) sample of 143 preschoolers. When the commonly used split at the 10th percentile rank was applied to classify intrauterine growth restriction (IUGR), we found that the growth restricted group (n = 25) exhibited significantly poorer performance in the global motor domain, but not on any other neuropsychological measure. In contrast, when adequacy of intrauterine growth was indexed by standardized birth weight, a continuous dimension, this early risk factor explained a unique portion of the variance in global cognitive abilities and visuospatial skills, as well as in global, fine, and gross motor skills. These findings are consistent with recent magnetic resonance imaging data disclosing global neurodevelopmental changes in the brains of preterm infants with IUGR. When cases classified with IUGR (<10th percentile) were excluded, the relationship between adequacy of intrauterine growth and global cognitive abilities remained significant despite range restriction. Hence, an association between appropriateness of intrauterine growth and global intellectual outcome may be observed even within the population of VLBW preschoolers with adequate standardized birth weight.

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Severity of perinatal cerebral injury and developmental outcome: A dose-response relationship.

Cited by 10 publications

References 45 publications

School-Age Consequences of Birth Weight Less Than 750 g: A Review and Update

School-Age Consequences of Birth Weight Less Than 750 g: A Review and Update

Postnatal growth and neuropsychological performance in preterm-birth preschoolers.

Intrauterine Growth and Neuropsychological Performance in Very Low Birth Weight Preschoolers

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