Severe propranolol and ethanol overdose with wide complex tachycardia treated with intravenous lipid emulsion: A case report

Abstract

We believe that lipid emulsion had a beneficial effect in the treatment of propranolol toxicity.

In vitro suppression of drug‐induced methaemoglobin formation by Intralipid® in whole human blood: observations relevant to the ‘lipid sink theory’*

“…This response or 'plateau effect' appears to be present in other studies [15]. Jovic-Stosic et al recently reported the successful use of Intralipid at doses exceeding 24 mg.ml )1 in a patient presenting with severe propranolol and ethanol toxicity [33]. Study 3 suggests that the lipid solubility of the drug administered in overdose (as suggested by the log P value) may give an indication of the potential benefit of lipid emulsion; there may be little benefit in administering lipid emulsion to treat toxicity from lipid insoluble drugs [34].…”

Kreislaufstillstand in besonderen Situationen

“…Therapieerfolge sind beim Einsatz von Glucagon (50-150 μg/kgKG, [357][358][359][360][361][362][363][364][365][366][367][368][369][370]), hochdosierter Insulin-und Glukosegabe [371][372][373], Lipidemulsionen [374][375][376][377], Phosphodiesterasehemmern [378,379], extrakorporaler Unterstützung und IAPB-Einsatz (intraaortale Ballonpumpe, [380][381][382] …”

Propranolol Overdose: An Emergency Medicine Simulation Scenario

“…Signs and symptoms of toxicity are generally non-specific and may include coma, generalized tonicclonic seizures, cardiac arrhythmias, and respiratory distress [3][4]. Beta-blocker overdose is not uncommon, given its widespread use.…”