Severe human parechovirus sepsis beyond the neonatal period

Abstract

Here we describe a case of viral sepsis beyond the neonatal period caused by human parechovirus subtype 3 (HPeV-3), which manifested as cardio-respiratory failure, hepatitis, and necrotizing enterocolitis (NEC). HPeV-1 and 2 were originally classified as enteroviruses but the advent of sequence analysis led to them being recognized as a new genus in the picornavirus family. Subsequently, nine additional HPeV strains have been reported including HPeV-3 in 1999.(1) The spectrum of disease that these viruses may cause is still unknown, and they are rarely screened for in clinical practice.

Human parechovirus infections, Lyon, France, 2008–10: Evidence for severe cases

“…2 However, the recently emerged HPeV-3 3 has been associated with sepsis-like syndrome, meningitis, encephalitis and hepatitis in neonates and young infants. [4][5][6][7][8][9][10][11] were screened by real-time PCRs for HSV-1, HSV-2 and HEV. Additional real-time PCRs were performed in the event of encephalitis (VZV, EBV, CMV, HHV-6).…”

A Member of a New Picornaviridae Genus Is Shed in Pig Feces

“…Nevertheless, HPeVs are pathogens frequently associated with various enteric, nervous, or respiratory syndromes in young children (49,54). Another parechovirus, LV, was identified in bank voles (Myodes glareolus) in Europe and the United states (20).…”

Replication and Inhibitors of Enteroviruses and Parechoviruses

“…The majority of these cases are caused by HPeV-3 [ 33 ], which is the most pathogenic HPeV type. It is associated with paralysis, neonatal sepsis-like illness and sudden death in infected infants [ 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. The HPeVs have received very little attention from the scientific community in the past, but continuing reports of HPeV circulation all over the world are increasing awareness of the significance of this virus group.…”