Human parechovirus infections, Lyon, France, 2008–10: Evidence for severe cases

Human parechovirus type 3 infection: Cause of apnea in infants born prematurely

“…). Each cluster was related to strains that had been previously seen outside of Japan, although the clinical manifestations and ages differed from those of the present patients: from stools of children with acute gastroenteritis, nasopharyngeal swabs of children with upper respiratory infections, and/or from cerebrospinal fluid of infants <3 months with sepsis …”

Seroepidemiology of human parechovirus types 1, 3, and 6 in Yamagata, Japan, in 2014

“…However, the seroprevalence in children is only 10% and 13% in the Netherlands and Finland, respectively; the reason for this discrepancy is unknown . In contrast to HPeV1, HPeV3 causes epidemics every 2–3 years, mainly during summer, in temperate climates, including Japan and Europe . Although we are not sure that the endemicity of HPeV1 and epidemicity of HPeV3 influence their seroprevalence, the results of our seroepidemiological study suggest that HPeV3 infection is likely to be less common than HPeV1 infection.…”

Relevance of Human Parechovirus Detection in Cerebrospinal Fluid Samples From Young Infants With Sepsis-Like Illness

“…However, regarding some distinct genetic and biological properties, they were re‐named and re‐classified in the specific distinct genus Parechovirus that clusters now up to 16 HPeV genotypes . The clinical importance of HPeV infection was extensively explored worldwide . The majority of HPeV infections occur very early in life, mainly before the age of 1 year.…”

“…Developments of sensitive and specific molecular tests for HPeV RNA have recently improved HPeV detection and typing and have allowed to better understand HPeV epidemiology. Several recent studies have highlighted the great interest of a more systematic testing for HPeV infection in infants . However, to date, few clinical laboratories have implemented HPeV molecular tests to their routine in addition to human enteroviruses .…”

“…Several recent studies have highlighted the great interest of a more systematic testing for HPeV infection in infants . However, to date, few clinical laboratories have implemented HPeV molecular tests to their routine in addition to human enteroviruses . With the aim to set up the systematic detection of HPeV RNA in cerebrospinal fluid (CSF) collected from infants, we retrospectively investigated the presence of HPeV sequences in CSF specimens previously tested for routine diagnosis of viral infection.…”