Severe HDN due to anti‐Ce that required exchange tranfusion

Abstract

Anti-Ce caused severe HDN requiring exchange transfusion. This highlights the need for a close follow-up throughout pregnancy if unexpected RBC antibodies are present, to permit the provision of compatible blood in case of a rare antibody.

Combined Anti e and Anti C Rh Isoimmunisation and Severe Hyperbilirubinemia

“…Phototherapy and exchange transfusion remain the standard treatment modalities in these newborns with severe jaundice. However, considering similar pathophysiology to Rh isoimmunisation, early IVIG may prevent acute and severe onset of jaundice [3].…”

Evaluation of the clinical utility of maternal alloantibody screening as a surrogate to antiglobulin crossmatch procedures in resource limited settings

“…Many of the red blood cell (RBC) alloantibodies of the Rhesus system have been associated with HDFN; however, the severity of the disease is usually the greatest with antiD [18]. Prevention of RhD HDFN became feasible in the late 1960s after pioneering research by Finn Clarks and Freda; there was a dramatic decline in Rh HDFN [19,20].…”

Anti‐Ce complicating two consecutive pregnancies with increasing severity of haemolytic disease of the newborn

“…Although the Ce antigen (RH7) is absent in 32% of white Caucasians (Reid & Lomas‐Francis, 1997), HDN because of anti‐Ce is rare. Only two cases of severe HDN requiring exchange transfusions have been reported previously (Malde et al ., 2000; Wagner et al ., 2000). We have described a woman with anti‐Ce who had two consecutive pregnancies with increasing severity of haemolytic disease (HD).…”