Anti‐Ce complicating two consecutive pregnancies with increasing severity of haemolytic disease of the newborn

Abstract

The Ce antigen is expressed on red cells of individuals with Rh haplotypes, R1 or CDe and r' or Cde. However, anti-Ce is rare, and only two cases of severe haemolytic disease of the newborn (HDN) caused by this antibody have been described (Malde et al., 2000; Wagner et al., 2000). We describe a woman who was found to have anti-Ce in her second pregnancy, resulting in a neonate with HDN that required exchange transfusion. She subsequently had a twin pregnancy, where both the twins were affected by severe haemolytic disease (HD) of the fetus because of anti-Ce and required repeated fetal transfusions, followed by exchange transfusions after birth. This is the first reported case of HD caused by anti-Ce requiring fetal transfusions.

Alloimmunisation during pregnancy in Greece: need for nationwide HDFN prevention programme

“…Fortunately, in our case there were no signs of HDFN in none of the two neonates delivered by Caesarean section at 36 weeks of gestation. It is worth mentioning that anti‐Ce cases could be misidentified as anti‐C and hence underreported (Malde et al ., ; Ranasinghe et al ., ).…”

Donor deferral due to anemia: A tertiary care center-based study

“…This is in accordance with blood donor deferral rates found in the literature, which range from 3% to 15%. [10–12] In a blood donation program where the majority of blood donors were first time donors it is also a reflection of the prevalence of anemia in the adult population in the community. The prevalence of anemia in our study population was much lower than reported in our general population (1.8% vs 25%),[13] probably as majority of our donors are adult males (males, 98.3%; females, 1.7%).…”

Hemolytic Disease of the Fetus and Newborn

“…• Severe HDFN-anti-D and anti-c [31,32] • Mild disease-anti-C, anti-E, and anti-e [33][34][35][36][37] 6.1.1 D antigen and antibodies…”

“…Anti-e is usually a very rare cause of HDN; the disease is usually mild [68]. In addition to the above antibodies, there are many other antibodies belonging to Rh family which are associated with HDFN [35,69,70]. Table 3.…”