Severe circulatory derangement induced by intravenous fluorocarbon emulsion

Maki, Takashi; Hori, Motokazu; Idezuki, Y

doi:10.1016/0022-4804(72)90049-2

Cited by 14 publications

(4 citation statements)

References 8 publications

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“…In two experiments without the lungs in the circuit, an average of 94% of the original platelets remained after 30 min. This suggests that a slow rate of platelet removal during lung perfusion was due primarily to platelet dis- definite changes in pulmonary and in the lungs (8,9). In each Of the five perfusion experiments, the addition of dispersed FC-80 caused no change in ventilation pressure and only a slight increase (<2 cm water) in perfusion pressure.…”

Section: Supported By a Grant From The Johnmentioning

confidence: 92%

“…Subsequently, the ability of the dispersed perfluoro compounds to deliver oxygen to tissues of intact animals was demonstrated (4)(5)(6). Although it was clear that the dispersed perfluoro compound transported oxygen in vivo, its injection into the circulating blood was sometimes followed by derangements of circulatory and pulmonary function (7,8). Intravenous injection of emulsified fluorochemical caused a large decrease in the number of circulating blood platelets (9) and in some animals, there were gross lesions in the lungs and a marked increase in resistance to flow of blood through the lungs (10).…”

mentioning

confidence: 98%

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Accelerated Removal of Platelets during Perfusion of Isolated Lungs with Perfluoro Erythrocyte Substitute

Steinberg

Fisher

Sloviter

1979

Experimental Biology and Medicine

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Section: Supported By a Grant From The Johnmentioning

confidence: 92%

mentioning

confidence: 98%

Accelerated Removal of Platelets during Perfusion of Isolated Lungs with Perfluoro Erythrocyte Substitute

Steinberg

Fisher

Sloviter

1979

Experimental Biology and Medicine

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“…Verwendung yon Fluorocarbon-Emulsionen oder -Suspensionen als mSgliche Oe-Trager eines synthetischen Blutes (Clark et al, 1970a;Sloviter et al, 1970;Geyer, 1970b;Fujita et al, 1971;Maki et al, 1972;Clark et al, 1973 b) bzw. ffir eine Ganztier-Perfusion (Geyer et al, 1968 a, b ;Sloviter et al, 1969;Geyer, 1970a, b;Clark st al., 1970b).…”

Section: Tl Z~nder Und a Heintzenbergunclassified

O2-Löslichkeit in Fluorocarbonen

Zander

1974

Res. Exp. Med.

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Summary. 02 solubility coefficients at temperatures from 10 to 50°C were determined for those two fluorocarbons which are most current for the time being: perfluorotributylamine (FC 43, 3M Comp.) and perfluorotetrahydrobutylfuran (FC 75, 3M Comp.). After equilibration with gases of known oxygen partial pressure the measuring of 02 concentration was carried out with a manometric apparatus aecording to Van Slyke. The results of 300 determinations show that the HenryDalton law for 02 solubility is not fulfilled in FC 43 and FC 75. The measured values are used for the construction of two nomograms which allow to read the 02 concentration of the fluorocarbons directly in volume percent, if 02 partial pressure and temperature are known, and to determine easily the Bunsen solubility coefficient (ml 02/ml atm) for temperatures from 10 to 50°C. Schli~sselwSrter: O2-LSsliehkeit --Fluorocarbone.

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“…In addition, the emulsion with pluronic F68 is quite unstable and has to be infused immediately after preparation. Reports on allergic side effects in dogs and patients, anaphylactic reactions, and complement activation by Fluosol DA 20% administration were published [20,21], resulting in recommendations to give patients a 0.5-ml test dose of the drug in combination with corticosteroids before starting the infusion [22,23]. There is evidence that the majority of the side effects of Fluosol DA 20% treatment were caused by the surfactant pluronic F68.…”

Section: Perfluorocarbonsmentioning

confidence: 99%

Artificial Oxygen Carriers as Red Blood Cell Substitutes – Perfluorocarbons and Cell-Free Hemoglobin

Standl¹

2000

Transfus Med Hemother

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Forthcoming shortfall of blood products and persisting concerns about viral transmission and immunosuppressive side effects of allogeneic blood transfusion have reinforced the studies with alternative oxygen carriers in the last years. Modern perfluorochemicals and cell-free hemoglobin solutions can be applied without prior cross-matching and are now available as stable formulations with long shelf life. Both groups of oxygen carriers have shown their effectivity and tolerability in numerous animal studies. An emulsion of perflubron which has a 60% weight/volume relation is actually undergoing phase III studies with respect to its effectivity in augmented acute normovolemic hemodilution since it has been shown to reverse hemodynamic transfusion triggers. While clinical studies with human cross-linked hemoglobin (DCLHb) have been stopped last year because of the results of two clinical trials showing an increased mortality in patients with stroke and multiple injury shock being treated with DCLHb in comparison with saline, a phase III study with polymerized bovine hemoglobin HBOC-201 is actually being performed in noncardiac patients with perioperative bleeding. The objective of this multicenter study is to show that treatment with HBOC-201 can reduce or avoid allogeneic RBC transfusion. Besides its use in clinical transfusion protocols, artificial oxygen carriers have a unique potential to deliver oxygen to the tissues by plasmatic transport due to its different physiology of oxygenation when compared with conventional oxygenation provided by red blood cells. Future studies must show if these modern oxygen carriers are able to improve outcome of patients with impaired perfusion and organ oxygenation.

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Severe circulatory derangement induced by intravenous fluorocarbon emulsion

Cited by 14 publications

References 8 publications

Accelerated Removal of Platelets during Perfusion of Isolated Lungs with Perfluoro Erythrocyte Substitute

Accelerated Removal of Platelets during Perfusion of Isolated Lungs with Perfluoro Erythrocyte Substitute

O2-Löslichkeit in Fluorocarbonen

Artificial Oxygen Carriers as Red Blood Cell Substitutes – Perfluorocarbons and Cell-Free Hemoglobin

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