Accelerated Removal of Platelets during Perfusion of Isolated Lungs with Perfluoro Erythrocyte Substitute

Steinberg, Harry; Fisher, Aron B.; Sloviter, Henry A.

doi:10.3181/00379727-162-40641

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1982

1987

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Cited by 3 publications

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“…In animals with very little of their own blood supply left, perfluorochemicals show no direct ill effect on the lungs. Once platelets were administered, however, an interaction between the platelets and the perfluorochemical resulted in lesions caused by the filtration of platelets in the lungs(17). Perfluorodecalin, one of the compounds in Fluosol-DA, was prone to this problem(18).Clotting factors present in the blood are not replaced by perfluorochemical erythrocyte substitutes.Despite this, abnormal bleeding has not been a problem in the human or animal subjects who received the transfusions.…”

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confidence: 98%