Perfluorocarbon blood substitutes

Biro, George P.; Blais, Pierre; Rosen, Arthur L.

doi:10.1016/s1040-8428(87)80018-5

Cited by 97 publications

(28 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Perfluoropolymers such as Teflon (polytetrafluoroethylene) are widely used, pri marily for their mechanical properties, durability and in ertness. This includes applications as orthopaedic implants -such as artificial hips, knees and jaws -together with replacement vascular structures, including arteries and car Gas Solubility PFC liquids have a very high solubility for gases and it was this property that led to their assessment as vehicles for respiratory gas transport [1,2,[5][6][7][8][9][10][11] and for regulating gas supply to cell cultures [12,13]. 02 solubility in PFCs is typically 40-50 vol%, whereas C02 solubility can be 3-4 times greater.…”

Section: Generalmentioning

confidence: 99%

“…The in terested reader is therefore referred to recent specialist reviews in this area [1,2,[5][6][7][8][9][10][11]49],…”

Section: Biocompatiblity Testingmentioning

confidence: 99%

“…It is noteworthy that PFC emulsions developed for their cancer therapy-enhancing properties (i.e. increased intravenous persistence providing more prolonged ther apeutic effects ) are substantially different from those de veloped as, for example, resuscitation fluids, which ideally have low vascular retention times [5]. This example il lustrates that future generations of PFC emulsions will need to be 'tailor-made' depending upon their specific re quirements.…”

Section: Cancer Therapymentioning

confidence: 99%

See 2 more Smart Citations

Synthetic Oxygen Transport Fluids Based on Perfluorochemicals: Applications in Medicine and Biology

Lowe¹

1991

Vox Sanguinis

View full text Add to dashboard Cite

Recent advances in the development and assessment of synthetic oxygen transport fluids based on perfluorochemicals (PFCs) are reviewed. The basic properties of PFCs are outlined, together with the selection criteria for biomedical applications. PFCs must be emulsified for intravascular use and attention is focussed on the formulation and biocompatibility testing of both first- and second-generation emulsions and their components in man and other species. The multidisciplinary applications for PFCs in medicine and basic biomedical research are described, including the clinical use of Fluosol-DA 20% as an oxygen-carrying perfusate in percutaneous transluminal coronary angioplasty.

show abstract

Section: Generalmentioning

confidence: 99%

“…The in terested reader is therefore referred to recent specialist reviews in this area [1,2,[5][6][7][8][9][10][11]49],…”

Section: Biocompatiblity Testingmentioning

confidence: 99%

Section: Cancer Therapymentioning

confidence: 99%

See 1 more Smart Citation

Synthetic Oxygen Transport Fluids Based on Perfluorochemicals: Applications in Medicine and Biology

Lowe¹

1991

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

“…PFC fluids have been investigated as respiratory media (1-11) for treating ALI, pulmonary administration of drugs (2,32,33), radiologic imaging and diagnosis (34), artificial red blood cell substitution (2,35,36), and vitreous fluid substitution (6) in animal and human studies. All the reported studies have used a single pure PFC liquid.…”

mentioning

confidence: 99%

Perfluorochemical (PFC) Combinations for Acute Lung Injury: An In Vitro and In Vivo Study in Juvenile Rabbits

et al. 2003

View full text Add to dashboard Cite

Perfluorochemical (PFC) fluids of different physical properties were titrated and tested in vitro for physical properties that are appropriate for respiratory application. Two PFC liquids were studied: perfluoromethylcyclohexane (PP2), a liquid with high vapor pressure and low viscosity, and perfluoromethyldecalin (PP9), a fluid with low vapor pressure and high viscosity. Eighteen rabbits (2.05 Ϯ 0.07 kg; mean Ϯ SEM) were lunglavaged and randomized: group I, control group; group II, partial liquid ventilation with 75% PP2 and 25% PP9; group III, partial liquid ventilation with 50% PP2 and 50% PP9; and group IV, partial liquid ventilation with 25% PP2 and 75% PP9. Ventilator volumes were kept constant during the 4-h experiment. Cardiopulmonary measurements were performed every 30 min. The lung histology was examined. The in vitro study showed PFC [viscosity/vapor pressure (in cS and mm Hg, respectively)] as follows: 100% PP2 (0.88/141); 100% PP9 (3.32/2.9); 75% PP2 and 25% PP9 (1.26/107); 50% PP2 and 50% PP9 (1.63/13.7); and 25% PP2 and 75% PP9 (2.21/4.4). The in vivo experiments found that combinations of moderate vapor pressure (groups 3 and 4) demonstrated good gas exchange, compliance, and histo- The use of PFC as a medical material has been investigated during the past decades (1, 2). Liquid-assisted ventilation, filling the lungs with PFC liquids during mechanical ventilation, including TLV and PLV, has proven effective in treating acute respiratory failure of premature, neonatal, and adult lungs (1-11). The properties of different PFC liquids influence physiologic and cellular responses during PLV and affect the dosing strategy (1, 2); however, there are a limited number of PFC fluids appropriate for respiratory applications. Although several PFC liquids have been reported for liquid-assisted ventilation, including TLV and PLV (10, 12-18), there have been no studies exploring the effects of combining different PFC liquids to produce a fluid with optimum physical properties for respiratory therapy.All PFC liquids are immiscible to water, but they are soluble in each other (1). A PFC liquid suitable for respiratory application has the properties of high gas solubility and moderate vapor pressure and viscosity (2). Inasmuch as only a few PFC liquids are good candidates as a respiratory medium, a mixture

show abstract

“…The characteristics, mechanism of dissolution, transport and delivery of oxygen by fluorocarbon emulsions are fun damentally different from those which operate for blood [4,8,11], The phenomenon is a simple physical dissolution of the gases in the liquid carrier with no specific bonding interaction with the fluorocarbon molecules. This results in a continuous linear increase in the amount of oxygen dis solved versus oxygen available, as opposed to the S-shaped Barcroft saturation curve found for hemoglobin in blood ( fig.…”

Section: The Fluorocarbon Approach: An Outline Of Basic Principles Amentioning

confidence: 99%

Fluorocarbon-Based in vivo Oxygen Transport and Delivery Systems

Riess¹

1991

Vox Sanguinis

View full text Add to dashboard Cite

The approval of Fluosol, a fluorocarbon emulsion for oxygenating the myocardium during the transluminal coronary angioplasty procedure, is a landmark in the field of injectable oxygen carriers, the so-called blood substitutes. This review discusses the advances made since this first emulsion was initially developed about 12 years ago. Attention is focused on the progress achieved in the preparation and selection of new, better-defined and faster-excreted fluorocarbons, and better surfactants, improved emulsions, knowledge of structure/property relationships along with an improved understanding of the physiologic response to their administration. These advances have led to the development of a second generation of highly concentrated, fluid and stable injectable oxygen carriers suitable for a broad range of clinical applications. Prospects for further progress and future generations of emulsions are also outlined.

show abstract

Perfluorocarbon blood substitutes

Cited by 97 publications

References 117 publications

Synthetic Oxygen Transport Fluids Based on Perfluorochemicals: Applications in Medicine and Biology

Synthetic Oxygen Transport Fluids Based on Perfluorochemicals: Applications in Medicine and Biology

Perfluorochemical (PFC) Combinations for Acute Lung Injury: An In Vitro and In Vivo Study in Juvenile Rabbits

Fluorocarbon-Based in vivo Oxygen Transport and Delivery Systems

Contact Info

Product

Resources

About