Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease

Ahmad, Nasir; Ahmad, Khalid; Younus, Faheem

doi:10.1016/j.jinf.2006.03.025

Cited by 14 publications

(7 citation statements)

References 13 publications

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“…Ahmad et al. , 70 reported a case of severe adenovirus pneumonia following infliximab infusion for the treatment of Crohn's disease in a 35‐year‐old male patient. Adenovirus serotype 4 was isolated from the bronchoalveolar lavage fluid as well as from lung tissue of the patient.…”

Section: Other Virusesmentioning

confidence: 99%

The impact of treatment with tumour necrosis factor-α antagonists on the course of chronic viral infections: a review of the literature

Domm

Činátl

Mrowietz

2008

British Journal of Dermatology

146

111

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Biologics that antagonize the biological activity of tumour necrosis factor (TNF)-alpha, namely infliximab, etanercept and adalimumab, are increasingly used for treatment of immune-mediated inflammatory diseases, including psoriasis, worldwide. TNF-alpha antagonists are known to increase the risk of reactivation and infection, particularly of infections with intracellular bacteria such as Mycobacterium tuberculosis. More frequently these agents are given to patients with viral infections. Viral hepatitis and human immunodeficiency virus infections are often present in these patients, with a considerable geographical variation. Other concomitant viral infections such as herpes, cytomegalovirus and varicella zoster virus may occur much more frequently than tuberculosis or leprosy. General recommendations about the management related to possible problems associated with anti-TNF-alpha treatment and these viral infections are lacking. This short review will give an overview of the most recent data available on the effects of anti-TNF-alpha therapy on viral infections with a particular focus on patient management and screening recommendations.

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Section: Other Virusesmentioning

confidence: 99%

The impact of treatment with tumour necrosis factor-α antagonists on the course of chronic viral infections: a review of the literature

Domm

Činátl

Mrowietz

2008

British Journal of Dermatology

146

111

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“…35 However, regular infusions of infliximab are expensive. 36 Furthermore, there are also concerns that systemic infliximab therapy may be associated with an increased risk of opportunistic infections from various microbial, viral, and fungal pathogens, [37][38][39][40] lymphoma, 41 and may reactivate latent tuberculosis. 42 Recently, localized delivery of infliximab has been proposed for the treatment of perianal fistulae in CD.…”

Section: Traditional Approaches For Fistula Treatment Medicalmentioning

confidence: 99%

Perianal fistulae in Crohnʼs Disease: Current and future approaches to treatment

Keshaw¹,

Foong²,

Forbes³

et al. 2010

Inflammatory Bowel Diseases

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: affecting sphincter integrity and continence. Traditional surgical and medical approaches are not without their limitations and may result in either comorbidity, such as fecal incontinence, or incomplete healing of the fistulae. Over the last 2 decades these limitations have led to a paradigm shift toward the use of biomaterials, and more recently cell-based therapies, which have met with variable degrees of success. This review discusses the traditional and current methods of treatment, as well as emerging and possible alternative approaches that may improve fistula healing.

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“…Moreover, it was found that tumor necrosis factor (TNF)-and IFN-secretion are significantly increased, and IL-2 cytokine levels were moderately increased after transfection of recombinant GII/4 norovirus capsid protein gene into BALB/c mice [73]. TNF-has been suggested to be associated with the defense against adenovirus infection [90].…”

Section: Transmissions Of Gastroenteroviruses and Host Immune Responsesmentioning

confidence: 99%

Gastroenteroviruses Infection in Taiwan

Tsai

Cheng³

et al. 2009

TOIDJ

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Acute infectious gastroenteritis causes high morbidity and mortality in children worldwide. The most important cause of gastroenteritis is virus infection. Diarrhea is the dominant symptom of viral gastroenteritis. It subsequently induces dehydration and malnutrition, which contribute to high morbidity and mortality in children. In Taiwan, rotavirus is the major cause (30.4-48%) of infectious gastroenteritis, followed by adenovirus (9.1-19.8%), norovirus (8.2-25%), enterovirus (< 5.2 %), astrovirus (2.7-2.9%) and other viruses (including sapovirus)(< 1 %). Untreated gastroenteritis is the major cause of infantile mortality, which leads to human tragedy and economic burden. In Taiwan, the cost of admission or hospitalization associated with gastroenterovirus infection is about more than 40% of the monthly salary of an unskilled or service worker. Understanding the epidemiology of gastroenterovirus and its induced host immune response could benefit the development for prevention and therapeutic management of gastroenterovirus. This review summarizes the epidemiological information and current knowledge of gastroenteroviruses that cause gastroenteritis in Taiwan.

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Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease

Cited by 14 publications

References 13 publications

The impact of treatment with tumour necrosis factor-α antagonists on the course of chronic viral infections: a review of the literature

The impact of treatment with tumour necrosis factor-α antagonists on the course of chronic viral infections: a review of the literature

Perianal fistulae in Crohnʼs Disease: Current and future approaches to treatment

Gastroenteroviruses Infection in Taiwan

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