Background Being an isolated locality and having a tough mountainous terrain, strong ethnomedicinal practices still prevail in Dhirkot and its allied areas, which have been rarely explored yet. The present study was intended with the aim to document and compare the traditional knowledge of local communities on botanical taxa of Dhirkot, Azad Jammu, and Kashmir. Methodology Ethnomedicinal data were collected from 74 informants using a semi-structured questionnaire in addition to field observation and group discussion. Various indices were also used to evaluate the ethnomedicinal data. Furthermore, the present findings were compared with previous reports to assess data novelty. Result A total of 140 medicinal plant species belonging to 55 families were recorded, which are used by local communities to treat 12 disease categories. Asteraceae was dominating with 20 species, followed by Poaceae, Lamiaceae, and Rosaceae (14, 11, and 10 species, respectively). Herbs were leading with 66% contribution, whereas leaves were the most utilized plant part with 29% utilization and decoction was the common mode of administration. Viola canescens depicted the highest use value and relative frequency of citation (1.7 and 0.92, respectively). Maximum informant consensus factor (0.88) was calculated for digestive and liver disorders. Five plant species including Berberis lycium Mentha arvensis Pyrus malus , Taraxacum officinale , and Viola canescens had 100% fidelity level. Conclusion Dhirkot and its allied areas harbor rich botanical and cultural diversity because of its unique geography and diverse climatic conditions. However, mostly, traditional ethnobotanical knowledge is restricted to healers, midwives, and older people, and could be extinct in the near future. Therefore, such documentation not only conserves traditional knowledge but may also contribute significantly to novel drug resources.

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BackgroundIndigenous communities of the Thakht-e-Sulamian hills reside in the North-West tribal belt of Pakistan, where disadvantaged socio-economic frames, lack of agricultural land and food insecurity represent crucial problems to their survival. Several studies in diverse areas worldwide have pointed out the importance of wild food plants (WFPs) for assuring food sovereignty and food security, and therefore the current study was aimed at documenting traditional knowledge of WFPs and analyzing how this varies among generations.MethodsEthnobotanical data were collected during 2010–2012. In total of seventy-two informants were interviewed in ten villages via in-depth interviews and group discussions with key informants followed by freelisting. Data were analyzed through descriptive and inferential statistics and novelty was checked by comparing the gathered data with the published literature.ResultsA total of fifty-one WFP species belonging to twenty-eight families were documented. Rosaceae was the dominant family with the largest number of species and highest frequency of citation (FC). July was the peak month for availability of WFPs, and fruit was the most commonly consumed part. Among the most cited species, Olea ferrugenia was ranked first with a FC = 1, followed by Amaranthus spinosus (FC = 0.93). Of the documented species about 14 % (7) were marketable and 27 % (14) were reported for the first time to be used as WFP species in Pakistan.ConclusionWFPs still play an important role in the food and culture of the study area and the folk knowledge attached to them is remarkable in the region, although declining among the younger generations. The recorded species needs to be re-evaluated in local projects aimed at fostering endogenous strategies of food security, as well as re-evaluating cultural heritage and sustaining small-scale food market circuits.

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BackgroundMutations in the gene encoding filamin A (FLNA) lead to diseases with high phenotypic diversity including periventricular nodular heterotopia, skeletal dysplasia, otopalatodigital spectrum disorders, cardiovascular abnormalities, and coagulopathy. FLNA mutations were recently found to be associated with lung disease. In this study, we report a novel FLNA gene associated with significant lung disease and unique angiogenesis.Case presentationHere, we describe a 1-year-old Saudi female child with respiratory distress at birth. The child then had recurrent lower respiratory tract infections, bilateral lung emphysema with basal atelectasis, bronchospasm, pulmonary artery hypertension, and oxygen and mechanical ventilation dependency. Molecular testing showed a new pathogenic variant of one copy of c.3153dupC in exon 21 in the FLNA gene.ConclusionsOur data support previous reports in the literature that associate FLNA gene mutation and lung disease.

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Wild vegetables can contribute to people’s food security and health. In northwest Pakistan, almost 40% of the households are classified as food insecure, due to increasing population and natural and man-made catastrophes. There is an urgent need to get an overview of still existing practices of wild vegetable use and to incorporate such knowledge into agricultural policies. The present study, therefore, aims to collect and analyze information on the most widely and commonly used wild vegetables in northwest Pakistan. Semistructured interviews were performed with 126 informants (26–78-year old) from all 24 districts of the Khyber Pakhtunkhwa Province. Information on culinary and medicinal use, cooking methods, and growing and harvest season were collected. A rating scale was used to get the opinion on quality, abundance, and use frequency of wild vegetables. Information on trading was gathered on local and regional markets. Transect walks were done with key informants for specimen collection. A total of 25 wild vegetable species (21 genera, 13 families) were documented. Most of them are herbs (22 spp.). One third of the species needs processing or detoxification prior to cooking. Taste and food quality as perceived by the local people are the main driver for use frequency and commercialization. Length of availability varies from 2 to 7 months with <em>Rumex dentatus</em> and <em>Vicia faba</em> also available during the winter season. Overall, 21 spp. are also used medicinally, mainly for gastrointestinal diseases. Leaves are the preferred plant part for both vegetables and medicines. Nine species are sold in markets, <em>Bauhinia variegata</em> and <em>Caralluma tuberculata</em> throughout the whole province. Local communities in northwest Pakistan have a broad knowledge of local plant use, especially on wild vegetables and their adequate processing. The present study suggests that the most commonly used wild vegetables should be promoted to reinforce food safety and most of them may also be commercialized. Conservation priority has to be given to the commercially harvested <em>Caralluma tuberculata</em>, which is presently overexploited.