Seventy-five gram glucose tolerance test to assess carbohydrate malabsorption and small bowel bacterial overgrowth

Abstract

Insulin resistance may be overestimated by using these markers if the patient has carbohydrate malabsorption, or that carbohydrate malabsorption may be present prior to the development of insulin resistance. Hence carbohydrate malabsorption should be taken into account for estimating insulin resistance and beta-cell function.

Accelerated Gastric Emptying but No Carbohydrate Malabsorption 1 Year After Gastric Bypass Surgery (GBP)

“…In addition, d -xylose is a synthetic sugar and its absorption may not reflect the absorption of glucose or other natural sugars. A breath hydrogen test following an oral glucose load may be a better measure of carbohydrate malabsorption than serum d -xylose [27]. …”

Steinert's syndrome presenting as anal incontinence: a case report

“…For the diagnosis of bacterial overgrowth, hydrogen and methane breath tests are the most important diagnostic methods [8-11]. These tests have three major drawbacks.…”

Hydrogen Breath Testing in Adults

“…They are normal and plentiful in the large intestine and produce hydrogen as a by-product of fermentation of carbohydrates. This hydrogen gas production in the human body results from the activity of the intestinal bacteria, which are the sole source of gut hydrogen and methane (Simren & Stotzer, 2005;Urita et al, 2006). Carbon dioxide is produced by all cells during metabolism, but only bacteria produce hydrogen and methane as metabolic by-products.…”

“…estimate small bowel transit time (Mastropaolo & Rees, 1987;Simren & Stotzer, 2005;Urita et al, 2006). Hydrogen breath testing consists of the oral administration of a predetermined dose of carbohydrate (often lactulose) to the patient, with subsequent breath sample collection at predetermined time intervals (i.e., every 15 minutes) for a 2-to 3-hour time period.…”